LOCUS       SIU02122.1               202 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 dtdp-
            4-dehydrorhamnose 3,5-epimerase rmlc (dtdp-4-keto-6-deoxyglucose
            3,5-epimerase) (dtdp-l-rhamnose synthetase) (thymidine
            diphospho-4-keto-rhamnose 3,5-epimerase) protein.
ACCESSION   LT708304-3536
PROTEIN_ID  SIU02122.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="rmlC"
                     /locus_tag="BQ2027_MB3494"
                     /standard_name="rfbC"
                     /note="Mb3494, rmlC, len: 202 aa. Equivalent to Rv3465,
                     len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 202 aa overlap). Probable rmlC
                     (alternate gene name: rfbC), dtdp-4-dehydrorhamnose
                     3,5-epimerase (EC 5.1.3.13), nearly identical to
                     O33170|RMLC RMLC PROTEIN from Mycobacterium tuberculosis
                     (203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5%
                     identity in 200 aa overlap) (previously known as rfbC).
                     Equivalent to Q9X7A4|RMLC|ML1965 PUTATIVE
                     DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE from Mycobacterium
                     leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64,
                     (75.4% identity in 199 aa overlap). Also highly similar to
                     others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis
                     (198 aa), FASTA scores: opt: 671, E(): 7e-38, (51.3%
                     identity in 193 aa overlap); Q9L6C5 from Streptomyces
                     antibioticus (202 aa), FASTA scores: opt: 665, E():
                     1.8e-37, (49.25% identity in 197 aa overlap);
                     P29783|STRM_STRGR from Streptomyces griseus (200 aa),
                     FASTA scores: opt: 608, E(): 1.2e-33, (49.25% identity in
                     201 aa overlap); Q54265|STRM from Streptomyces glaucescens
                     (200 aa), FASTA scores: opt: 603, E(): 2.5e-33, (46.7%
                     identity in 197 aa overlap); etc. Also highly similar to
                     Q9S4D4|TYLJ PUTATIVE NDP-HEXOSE 3-EPIMERASE from
                     Streptomyces fradiae (205 aa), FASTA scores: opt: 625,
                     E(): 8.6e-35, (45.9% identity in 194 aa overlap). Protein
                     product from Mb3494 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3494 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4B1"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4B1"
BEGIN
        1 MKARELDVPG AWEITPTIHV DSRGLFFEWL TDHGFRAFAG HSLDVRQVNC SVSSAGVLRG
       61 LHFAQLPPSQ AKYVTCVSGS VFDVVVDIRE GSPTFGRWDS VLLDDQDRRT IYVSEGLAHG
      121 FLALQDNSTV MYLCSAEYNP QREHTICATD PTLAVDWPLV DGAAPSLSDR DAAAPSFEDV
      181 RASGLLPRWE QTQRFIGEMR GT
//