LOCUS SIU01630.1 334 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA2 (NAD(
P)H-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) protein.
ACCESSION LT708304-3044
PROTEIN_ID SIU01630.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="gpdA2"
/locus_tag="BQ2027_MB3006C"
/standard_name="gpsA"
/note="Mb3006c, gpdA2, len: 334 aa. Equivalent to Rv2982c,
len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,
(99.7% identity in 334 aa overlap). Probable gpdA2
(alternate gene name: gpsA), glycerol-3-phosphate
dehydrogenase [NAD(P)+] (EC 1.1.1.94), equivalent to
Q9CBR9|GPDA_MYCLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE
[NAD(P)+] from Mycobacterium leprae (349 aa), FASTA
scores: opt: 1686, E(): 1.7e-95, (77.95% identity in 349
aa overlap). Also highly similar to others e.g.
Q9ZBS0|GPDA_STRCO from Streptomyces coelicolor (336 aa),
FASTA scores: opt: 1165, E(): 9.8e-64, (56.25% identity in
327 aa overlap); P46919|GPDA_BACSU from Bacillus subtilis
(345 aa), FASTA scores: opt: 872, E(): 7.5e-46, (44.9%
identity in 325 aa overlap);
P37606|GPDA_ECOLI|GPSA|B3608|Z5035|ECS4486. from
Escherichia coli strain O157:H7 and K12 (339 aa), FASTA
scores: opt: 799, E(): 2.1e-41, (42.9% identity in 331 aa
overlap); etc. Also highly similar to O53761|GPD2_MYCTU
PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE from
Mycobacterium tuberculosis (341 aa), FASTA scores: opt:
740, E(): 8.4e-38, (40.35% identity in 322 aa overlap).
BELONGS TO THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE
DEHYDROGENASE FAMILY. Protein product from Mb3006c
detected using shotgun mass spectrometry and SWATH mass
spectrometry. Mb3006c found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:P59961"
/db_xref="InterPro:IPR006109"
/db_xref="InterPro:IPR006168"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR011128"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P59961"
BEGIN
1 MAGIASTVAV MGAGAWGTAL AKVLADAGGE VTLWARRAEV ADQINTTRYN PDYLPGALLP
61 PSIHATADAE EALGGASTVL LGVPAQTMRA NLERWAPLLP EGATLVSLAK GIELGTLMRM
121 SQVIISVTGA EPAQVAVISG PNLASEIAEC QPAATVVACS DSGRAVALQR ALNSGYFRPY
181 TNADVVGTEI GGACKNIIAL ACGMAVGIGL GENTAAAIIT RGLAEIIRLG TALGANGATL
241 AGLAGVGDLV ATCTSPRSRN RSFGERLGRG ETLQSAGKAC HVVEGVTSCE SVLALASSYD
301 VEMPLTDAVH RVCHKGLSVD EAITLLLGRR TKPE
//