LOCUS       SIU01630.1               334 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA2 (NAD(
            P)H-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) protein.
ACCESSION   LT708304-3044
PROTEIN_ID  SIU01630.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="gpdA2"
                     /locus_tag="BQ2027_MB3006C"
                     /standard_name="gpsA"
                     /note="Mb3006c, gpdA2, len: 334 aa. Equivalent to Rv2982c,
                     len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 334 aa overlap). Probable gpdA2
                     (alternate gene name: gpsA), glycerol-3-phosphate
                     dehydrogenase [NAD(P)+] (EC 1.1.1.94), equivalent to
                     Q9CBR9|GPDA_MYCLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE
                     [NAD(P)+] from Mycobacterium leprae (349 aa), FASTA
                     scores: opt: 1686, E(): 1.7e-95, (77.95% identity in 349
                     aa overlap). Also highly similar to others e.g.
                     Q9ZBS0|GPDA_STRCO from Streptomyces coelicolor (336 aa),
                     FASTA scores: opt: 1165, E(): 9.8e-64, (56.25% identity in
                     327 aa overlap); P46919|GPDA_BACSU from Bacillus subtilis
                     (345 aa), FASTA scores: opt: 872, E(): 7.5e-46, (44.9%
                     identity in 325 aa overlap);
                     P37606|GPDA_ECOLI|GPSA|B3608|Z5035|ECS4486. from
                     Escherichia coli strain O157:H7 and K12 (339 aa), FASTA
                     scores: opt: 799, E(): 2.1e-41, (42.9% identity in 331 aa
                     overlap); etc. Also highly similar to O53761|GPD2_MYCTU
                     PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE from
                     Mycobacterium tuberculosis (341 aa), FASTA scores: opt:
                     740, E(): 8.4e-38, (40.35% identity in 322 aa overlap).
                     BELONGS TO THE NAD-DEPENDENT GLYCEROL-3-PHOSPHATE
                     DEHYDROGENASE FAMILY. Protein product from Mb3006c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3006c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P59961"
                     /db_xref="InterPro:IPR006109"
                     /db_xref="InterPro:IPR006168"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR011128"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/Swiss-Prot:P59961"
BEGIN
        1 MAGIASTVAV MGAGAWGTAL AKVLADAGGE VTLWARRAEV ADQINTTRYN PDYLPGALLP
       61 PSIHATADAE EALGGASTVL LGVPAQTMRA NLERWAPLLP EGATLVSLAK GIELGTLMRM
      121 SQVIISVTGA EPAQVAVISG PNLASEIAEC QPAATVVACS DSGRAVALQR ALNSGYFRPY
      181 TNADVVGTEI GGACKNIIAL ACGMAVGIGL GENTAAAIIT RGLAEIIRLG TALGANGATL
      241 AGLAGVGDLV ATCTSPRSRN RSFGERLGRG ETLQSAGKAC HVVEGVTSCE SVLALASSYD
      301 VEMPLTDAVH RVCHKGLSVD EAITLLLGRR TKPE
//