LOCUS SIU01560.1 370 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Xaa-
Pro dipeptidase (EC protein.
ACCESSION LT708304-2974
PROTEIN_ID SIU01560.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/locus_tag="BQ2027_MB2939C"
/EC_number="3.4.13.9"
/note="Mb2939c, -, len: 370 aa. Equivalent to Rv2915c,
len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 370 aa overlap). Conserved
hypothetical protein, posssibly XAA-PRO dipeptidase
(prolidase) (EC 3.4.13.9), highly similar to
CAC38796|SCI39.08c CONSERVED HYPOTHETICAL PROTEIN from
Streptomyces coelicolor (363 aa), FASTA scores: opt: 1341,
E(): 5.5e-76, (56.65% identity in 362 aa overlap); and
similar to prolidases (XAA-PRO dipeptidase) e.g.
Q9ABC9|CC0300 PUTATIVE XAA-PRO DIPEPTIDASE from
Caulobacter crescentus (428 aa), FASTA scores: opt: 327,
E(): 7.4e-13, (30.2% identity in 374 aa overlap); Q97XD4
PROLIDASE from Sulfolobus solfataricus (396 aa), FASTA
scores: opt: 271, E(): 2.1e-09, (30.5% identity in 354 aa
overlap); Q9WX55 PROLIDASE from Microbacterium
esteraromaticum (393 aa), FASTA scores: opt: 256, E():
1.8e-08, (27.95% identity in 365 aa overlap); etc. Also
similar to O53619|Rv0074|MTV030.18 CONSERVED HYPOTHETICAL
PROTEIN from Mycobacterium tuberculosis (411 aa), FASTA
scores: opt: 243, E(): 1.2e-07, (27.5% identity in 389 aa
overlap). Protein product from Mb2939c detected using
SWATH mass spectrometry. Mb2939c found to be expressed
during exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:P68916"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/Swiss-Prot:P68916"
BEGIN
1 MKRVDTIRPR SRAVRLHVRG LGLPDETAIQ LWIVDGRIST EPVAGADTVF DGGWILPGLV
61 DAHCHVGLGK HGNVELDEAI AQAETERDVG ALLLRDCGSP TDTRGLDDHE DLPRIIRAGR
121 HLARPKRYIA GFAVELEDES QLPAAVAEQA RRGDGWVKLV GDWIDRQIGD LAPLWSDDVL
181 KAAIDTAHAQ GARVTAHVFS EDALPGLINA GIDCIEHGTG LTDDTIALML EHGTALVPTL
241 INLENFPGIA DAAGRYPTYA AHMRDLYARG YGRVAAAREA GVPVYAGTDA GSTIEHGRIA
301 DEVAALQRIG MTAHEALGAA CWDARRWLGR PGLDDRASAD LLCYAQDPRQ GPGVLQHPDL
361 VILRGRTFGP
//