LOCUS       SIU01560.1               370 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Xaa-
            Pro dipeptidase (EC protein.
ACCESSION   LT708304-2974
PROTEIN_ID  SIU01560.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2939C"
                     /EC_number="3.4.13.9"
                     /note="Mb2939c, -, len: 370 aa. Equivalent to Rv2915c,
                     len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 370 aa overlap). Conserved
                     hypothetical protein, posssibly XAA-PRO dipeptidase
                     (prolidase) (EC 3.4.13.9), highly similar to
                     CAC38796|SCI39.08c CONSERVED HYPOTHETICAL PROTEIN from
                     Streptomyces coelicolor (363 aa), FASTA scores: opt: 1341,
                     E(): 5.5e-76, (56.65% identity in 362 aa overlap); and
                     similar to prolidases (XAA-PRO dipeptidase) e.g.
                     Q9ABC9|CC0300 PUTATIVE XAA-PRO DIPEPTIDASE from
                     Caulobacter crescentus (428 aa), FASTA scores: opt: 327,
                     E(): 7.4e-13, (30.2% identity in 374 aa overlap); Q97XD4
                     PROLIDASE from Sulfolobus solfataricus (396 aa), FASTA
                     scores: opt: 271, E(): 2.1e-09, (30.5% identity in 354 aa
                     overlap); Q9WX55 PROLIDASE from Microbacterium
                     esteraromaticum (393 aa), FASTA scores: opt: 256, E():
                     1.8e-08, (27.95% identity in 365 aa overlap); etc. Also
                     similar to O53619|Rv0074|MTV030.18 CONSERVED HYPOTHETICAL
                     PROTEIN from Mycobacterium tuberculosis (411 aa), FASTA
                     scores: opt: 243, E(): 1.2e-07, (27.5% identity in 389 aa
                     overlap). Protein product from Mb2939c detected using
                     SWATH mass spectrometry. Mb2939c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P68916"
                     /db_xref="InterPro:IPR006680"
                     /db_xref="InterPro:IPR032466"
                     /db_xref="UniProtKB/Swiss-Prot:P68916"
BEGIN
        1 MKRVDTIRPR SRAVRLHVRG LGLPDETAIQ LWIVDGRIST EPVAGADTVF DGGWILPGLV
       61 DAHCHVGLGK HGNVELDEAI AQAETERDVG ALLLRDCGSP TDTRGLDDHE DLPRIIRAGR
      121 HLARPKRYIA GFAVELEDES QLPAAVAEQA RRGDGWVKLV GDWIDRQIGD LAPLWSDDVL
      181 KAAIDTAHAQ GARVTAHVFS EDALPGLINA GIDCIEHGTG LTDDTIALML EHGTALVPTL
      241 INLENFPGIA DAAGRYPTYA AHMRDLYARG YGRVAAAREA GVPVYAGTDA GSTIEHGRIA
      301 DEVAALQRIG MTAHEALGAA CWDARRWLGR PGLDDRASAD LLCYAQDPRQ GPGVLQHPDL
      361 VILRGRTFGP
//