LOCUS       SIU01214.1               597 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 LONG
            CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] protein.
ACCESSION   LT708304-2628
PROTEIN_ID  SIU01214.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2596"
                     /note="Mb2596, -, len: 597 aa. Equivalent to 3' end of
                     Rv2566, len: 1140 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.8% identity in 597 aa overlap). Long
                     conserved hypothetical protein, equivalent to
                     O53120|ML2678 OR MLCB1913.12 HYPOTHETICAL PROTEIN from
                     Mycobacterium leprae (1000 aa), FASTA scores: opt: 760,
                     E(): 7.1e-38, (50.2% identity in 1128 aa overlap); and
                     middle part equivalent to Q9ZB40 72.2 KDA PROTEIN
                     (FRAGMENT) from Mycobacterium leprae (644 aa), FASTA
                     scores: opt: 1017, E(): 1.5e-65, (45.65% identity in 655
                     aa overlap). Also highly similar to Q98HG6|MLL2877
                     HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium
                     loti) (1119 aa), FASTA scores: opt: 1413, E(): 3.7e-77,
                     (52.4% identity in 1148 aa overlap); and N-terminus shows
                     similarity with other proteins e.g. Q9HUN8|PA4926
                     HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (311 aa),
                     FASTA scores: opt: 278, E(): 3e-09, (29.95% identity in
                     284 aa overlap); and upstream ORF
                     Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 CONSERVED
                     HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (314
                     aa), FASTA scores: opt: 252, E(): 1.1e-07, (28.9% identity
                     in 315 aa overlap). Equivalent to AAK46955 from
                     Mycobacterium tuberculosis strain CDC1551 (1156 aa) but
                     shorter 16 aa. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as
                     a single gene. In Mycobacterium bovis, a frameshift due to
                     a 2 bp deletion (gc-*) splits Rv2566 into 2 parts, Mb2595
                     and Mb2596. Protein product from Mb2596 detected using
                     SWATH mass spectrometry."
                     /db_xref="InterPro:IPR018667"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1K2"
BEGIN
        1 MLPLHRRDDG QGWASANWRL RRGRIVLLEG DSPAGLRLPL DSISWRPPRA SFDADPVAVR
       61 STLPAEPHTD RAVVEDPETA PTTALVAEVR GGLVHIFLPP TDALEHFIDL VARVEAAATT
      121 ANCPVVIEGY GPPPDPRLTS TTITPDPGVI EVNIAPTASF AEQRQQLETL YQQARLARLT
      181 TEAFDVDGTH GGTGGGNHIT LGGVTPADSP LLRRPDLLVS LLTYWQRHPS LSYLFAGRFV
      241 GTTSQAPRVD EGRAEALYEL EIAFAEILRL SPSSGGGRPQ PWVTDRALRH LLTDITGNTH
      301 RAEFCIDKLY SPDSARGRLG LLELRGFEMP PHLHMAMVQS LLVRSLVAWF WDQPLRAPLI
      361 RHGANLHGRY LLPHFLIHDI ADVAADLRAH GIAFETSWLD PFTEFRFPRI GTAVFDGIEI
      421 ELRGAIEPWH TLGEEATAAG TARYVDSSVE RIQVRIIGAD RHRYVVTCNG YPMPLLATDN
      481 PDIHVGGVRF KAWQPPSALH PTITVDGPLR FELIDIATAT SCGGCTYHVA HPGGRAYDEP
      541 PVNAVEAEAR RARRFEATGF TPGKLDLSDI REKQARISTD IGAPGILDLR RVRTVQQ
//