LOCUS SIU01131.1 1137 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
TRANSCRIPTIONAL REGULATORY PROTEIN (LUXR-FAMILY) protein.
ACCESSION LT708304-2545
PROTEIN_ID SIU01131.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/locus_tag="BQ2027_MB2515C"
/note="Mb2515c, -, len: 1137 aa. Equivalent to Rv2488c,
len: 1137 aa, from Mycobacterium tuberculosis strain
H37Rv, (100.0% identity in 1137 aa overlap). Probable
transcriptional regulatory protein, belonging to luxR
family, similar to many in Mycobacterium tuberculosis e.g.
AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA
scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093
aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv
(1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75%
identity in 1089 aa overlap); AAK45665|MT1402 from strain
CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190,
(52.0% identity in 1093 aa overlap); etc. Also similar to
transcriptional regulatory proteins luxR-family from other
organisms e.g. Q9CBP3|ML1753 from Mycobacterium leprae
(1106 aa), FASTA scores: opt: 2823, E(): 1.5e-156, (50.35%
identity in 1116 aa overlap); Q9KYF4|SCD72A.02 from
Streptomyces coelicolor (1114 aa), FASTA scores: opt: 915,
E(): 1.7e-45, (30.7% identity in 1143 aa overlap); etc.
Some similarity with Q9KXP6|SC9C5.28 HYPOTHETICAL 81.8 KDA
PROTEIN from Streptomyces coelicolor (750 aa), FASTA
scores: opt: 1085, E(): 1.6e-55, (35.45% identity in 722
aa overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-loop), PS00622 Bacterial regulatory proteins, luxR
family signature, probable coiled-coil from aa 585 to 616
and probable helix-turn-helix motif at aa 1086 to 1107
(score 1206, +3.29 SD). BELONGS TO THE LUXR/UHPA FAMILY OF
TRANSCRIPTIONAL REGULATORS. Protein product from Mb2515c
detected using SWATH mass spectrometry. Mb2515c found to
be expressed during exponential growth in Sauton's minimal
media by RNA-sequencing."
/db_xref="GOA:A0A1R3Y1C9"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR002182"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y1C9"
BEGIN
1 MDRRPRDFEQ SRRRCRCNAL RAGSMLASMS KIHPGVDVVP VDWSADGVSE LVPTGTVTLL
61 LADIEGATHL PGSQLDTTAI AKLDRTLTEL VREHRGVCPV EQGEGDSFLV AFARASDAVA
121 CALGLQRAPL APIRLRIGMH TGEVSSPDEG NCVGPTIDRT ARLRELAHGG QTVLSGTTSD
181 LVADLLPKDA WLNDLGTYRL DDLPRPERVV QLCHPDLHNA FPPLRTRKVV GAHCLPAQLT
241 RLVGRVDEVA QVRGLLDVKR WVTLTGVGGV GKTRLATQVA SAVADGYPDG VWYVNLAPIT
301 DPALVPIAAA RVLGLPDQPG RSTVDTIVRR IGDRRMLVVL DNCEHLLDGC AALIVALLGA
361 CPALRVLATS REPIAVAGEQ IWRVPPLGHG EAIELFTDRA REARPELEIT ADNLALVTEI
421 CHRLDGIPLA IELAASRVRA LALTEIVDSL HDRFRLLTGG SRIAVRRQQT MRASVDWSHA
481 LLTGPEQVLF RRLAVFPSGF DLDGAQAAAA GGDVQRYEVV DLLSLLADKS LVVTDDSDGR
541 TRYRLLETVR QYALEKLRES GDADAVRARH RDHYAAVAAG LDAPSVAGHE RRLNQAELEI
601 DNLRAAFAFS RENGDTGHAL LLASCLQPLW RARGRLQEGL AWFAAALADH DAHPAGADPG
661 LYARALADRA LIDAVAGITD RLDDAQKALA IARDIEDPAL LARALTACGG VAAYNADLAR
721 PWLAEAVGLA RAVGDKWRLA EVLAWQAYVG FAGEGDPGAT RAAGEEARSL ADEIGDAFLS
781 RSCRWALAAA NLWQGNLEAA VGLSREVIGE SDAAHDMVSS CAGQACLAHA LAHRGDTEAA
841 AAAQASIDTA VGLSPVLSGS ACSALVFATL AAGDVAAAEH ARESATRFFG ASAAAIINDP
901 TSSAQISCAR GDLNAAHRLA DGAASITRGV HRARALTTRC RIEIAQGDRH RAERDAHDAL
961 GVAASIGAYL WVPDILECLA SVMADAGSNR EAVRLFGAAD AARGRMGAVR FGIYQAGCNS
1021 SLATLRKSMG DSEFDDAWAE GTALSIDEAI AYAQRGRGAR KRPTSGWGAL TPTELEVALL
1081 VGEGLSNKEI GVRLFISPRT VHSHLTHVYT KLGLSSRLQL AQQAARRGES ERGPSRP
//