LOCUS SIU01131.1 1137 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (LUXR-FAMILY) protein. ACCESSION LT708304-2545 PROTEIN_ID SIU01131.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2515C" /note="Mb2515c, -, len: 1137 aa. Equivalent to Rv2488c, len: 1137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 1137 aa overlap). Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% identity in 1089 aa overlap); AAK45665|MT1402 from strain CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190, (52.0% identity in 1093 aa overlap); etc. Also similar to transcriptional regulatory proteins luxR-family from other organisms e.g. Q9CBP3|ML1753 from Mycobacterium leprae (1106 aa), FASTA scores: opt: 2823, E(): 1.5e-156, (50.35% identity in 1116 aa overlap); Q9KYF4|SCD72A.02 from Streptomyces coelicolor (1114 aa), FASTA scores: opt: 915, E(): 1.7e-45, (30.7% identity in 1143 aa overlap); etc. Some similarity with Q9KXP6|SC9C5.28 HYPOTHETICAL 81.8 KDA PROTEIN from Streptomyces coelicolor (750 aa), FASTA scores: opt: 1085, E(): 1.6e-55, (35.45% identity in 722 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature, probable coiled-coil from aa 585 to 616 and probable helix-turn-helix motif at aa 1086 to 1107 (score 1206, +3.29 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. Protein product from Mb2515c detected using SWATH mass spectrometry. Mb2515c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1C9" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001054" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR036388" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1C9" BEGIN 1 MDRRPRDFEQ SRRRCRCNAL RAGSMLASMS KIHPGVDVVP VDWSADGVSE LVPTGTVTLL 61 LADIEGATHL PGSQLDTTAI AKLDRTLTEL VREHRGVCPV EQGEGDSFLV AFARASDAVA 121 CALGLQRAPL APIRLRIGMH TGEVSSPDEG NCVGPTIDRT ARLRELAHGG QTVLSGTTSD 181 LVADLLPKDA WLNDLGTYRL DDLPRPERVV QLCHPDLHNA FPPLRTRKVV GAHCLPAQLT 241 RLVGRVDEVA QVRGLLDVKR WVTLTGVGGV GKTRLATQVA SAVADGYPDG VWYVNLAPIT 301 DPALVPIAAA RVLGLPDQPG RSTVDTIVRR IGDRRMLVVL DNCEHLLDGC AALIVALLGA 361 CPALRVLATS REPIAVAGEQ IWRVPPLGHG EAIELFTDRA REARPELEIT ADNLALVTEI 421 CHRLDGIPLA IELAASRVRA LALTEIVDSL HDRFRLLTGG SRIAVRRQQT MRASVDWSHA 481 LLTGPEQVLF RRLAVFPSGF DLDGAQAAAA GGDVQRYEVV DLLSLLADKS LVVTDDSDGR 541 TRYRLLETVR QYALEKLRES GDADAVRARH RDHYAAVAAG LDAPSVAGHE RRLNQAELEI 601 DNLRAAFAFS RENGDTGHAL LLASCLQPLW RARGRLQEGL AWFAAALADH DAHPAGADPG 661 LYARALADRA LIDAVAGITD RLDDAQKALA IARDIEDPAL LARALTACGG VAAYNADLAR 721 PWLAEAVGLA RAVGDKWRLA EVLAWQAYVG FAGEGDPGAT RAAGEEARSL ADEIGDAFLS 781 RSCRWALAAA NLWQGNLEAA VGLSREVIGE SDAAHDMVSS CAGQACLAHA LAHRGDTEAA 841 AAAQASIDTA VGLSPVLSGS ACSALVFATL AAGDVAAAEH ARESATRFFG ASAAAIINDP 901 TSSAQISCAR GDLNAAHRLA DGAASITRGV HRARALTTRC RIEIAQGDRH RAERDAHDAL 961 GVAASIGAYL WVPDILECLA SVMADAGSNR EAVRLFGAAD AARGRMGAVR FGIYQAGCNS 1021 SLATLRKSMG DSEFDDAWAE GTALSIDEAI AYAQRGRGAR KRPTSGWGAL TPTELEVALL 1081 VGEGLSNKEI GVRLFISPRT VHSHLTHVYT KLGLSSRLQL AQQAARRGES ERGPSRP //