LOCUS SIU01025.1 563 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 ferredoxin-
dependent sulfite reductase sira protein.
ACCESSION LT708304-2439
PROTEIN_ID SIU01025.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="sira"
/locus_tag="BQ2027_MB2412"
/note="Mb2412, nirA, len: 563 aa. Equivalent to Rv2391,
len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 563 aa overlap). Probable nirA,
ferredoxin-dependant nitrite reductase (EC 1.7.7.1),
similar to many nitrate reductases e.g.
CAC33947|SCBAC1A6.26c Putative nitrite/sulphite reductase
from Streptomyces coelicolor (565 aa), FASTA scores: opt:
2335, E(): 1.2e-137, (60.1% identity in 567 aa overlap);
Q9RZD6|DRA0013 FERREDOXIN-NITRITE REDUCTASE from
Deinococcus radiodurans (563 aa), FASTA scores: opt: 1141,
E(): 2.2e-63, (39.6% identity in 533 aa overlap);
Q59656|NIRA (D31732|PEENIRNRT_1) ferredoxin-dependant*
NITRITE REDUCTASE (*: see citation below) from Plectonema
boryanum (654 aa), FASTA scores: opt: 805, E(): 1.9e-42,
(31.7% identity in 517 aa overlap); Q55366|NIRA|SLR0898
FERREDOXIN-NITRITE REDUCTASE from Synechocystis sp. strain
PCC 6803 (502 aa), FASTA scores: opt: 799, E(): 3.7e-42,
(32.3% identity in 517 aa overlap). Highly similar (only
in N-terminal part because shortened protein (fragment)
owing to an IS900 insertion) to Q9K541|NIRA NITRATE
REDUCTASE (FRAGMENT) from Mycobacterium paratuberculosis
(198 aa), FASTA scores: opt: 798, E(): 2.1e-42, (65.4%
identity in 182 aa overlap). Protein product from Mb2412
detected using shotgun mass spectrometry and SWATH mass
spectrometry. Mb2412 found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:Q7TYP6"
/db_xref="InterPro:IPR005117"
/db_xref="InterPro:IPR006066"
/db_xref="InterPro:IPR006067"
/db_xref="InterPro:IPR036136"
/db_xref="UniProtKB/Swiss-Prot:Q7TYP6"
BEGIN
1 MSAKENPQMT TARPAKARNE GQWALGHREP LNANEELKKA GNPLDVRERI ENIYAKQGFD
61 SIDKTDLRGR FRWWGLYTQR EQGYDGTWTG DDNIDKLEAK YFMMRVRCDG GALSAAALRT
121 LGQISTEFAR DTADISDRQN VQYHWIEVEN VPEIWRRLDD VGLQTTEACG DCPRVVLGSP
181 LAGESLDEVL DPTWAIEEIV RRYIGKPDFA DLPRKYKTAI SGLQDVAHEI NDVAFIGVNH
241 PEHGPGLDLW VGGGLSTNPM LAQRVGAWVP LGEVPEVWAA VTSVFRDYGY RRLRAKARLK
301 FLIKDWGIAK FREVLETEYL KRPLIDGPAP EPVKHPIDHV GVQRLKNGLN AVGVAPIAGR
361 VSGTILTAVA DLMARAGSDR IRFTPYQKLV ILDIPDALLD DLIAGLDALG LQSRPSHWRR
421 NLMACSGIEF CKLSFAETRV RAQHLVPELE RRLEDINSQL DVPITVNING CPNSCARIQI
481 ADIGFKGQMI DDGHGGSVEG FQVHLGGHLG LDAGFGRKLR QHKVTSDELG DYIDRVVRNF
541 VKHRSEGERF AQWVIRAEED DLR
//