LOCUS CCP46198.1 501 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Halimadienyl diphosphate
synthase protein.
ACCESSION AL123456-3476
PROTEIN_ID CCP46198.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/locus_tag="Rv3377c"
/note="Rv3377c, (MTV004.35c), len: 501 aa. Halimadienyl
diphosphate synthase; similarity with various
proteins,notably cyclases involved in steroid biosynthesis
in plants and bacteria e.g. BAB52679|MLR6369 from
Rhizobium loti (Mesorhizobium loti) (516 aa), FASTA
scores: opt: 533, E(): 5.6e-27, (30.45% identity in 522 aa
overlap); Q9ZTN8 copalyl diphosphate synthase 1 from
Cucurbita maxima (Pumpkin) (Winter squash) (823 aa), FASTA
scores: opt: 484,E(): 1.2e-23, (28.35% identity in 388 aa
overlap); Q38710|AC22 abietadiene cyclase from Abies
grandis (868 aa), FASTA scores: opt: 382, E(): 5.2e-17,
(25.55% identity in 462 aa overlap); Q41771|AN1 kaurene
synthase a from Zea mays (Maize) (823 aa), FASTA scores:
opt: 377, E(): 1.1e-16, (29.75% identity in 390 aa
overlap); Q9AJE4 diterpene cyclase-1 from Kitasatospora
griseola (Streptomyces griseolosporeus) (499 aa), FASTA
scores: opt: 336, E(): 3.2e-14, (27.5% identity in 513 aa
overlap); Q9SAU6 E-alpha-bisabolene synthase (fragment)
from Abies grandis (782 aa), FASTA scores: opt: 317, E():
7.8e-13,(25.25% identity in 479 aa overlap); etc. Note
that this and the upstream ORF MTV004.36c have a
significantly lower GC bias than the rest of the genome.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007). Cofactor: Mg2+."
/db_xref="EnsemblGenomes-Gn:Rv3377c"
/db_xref="EnsemblGenomes-Tr:CCP46198"
/db_xref="GOA:O50406"
/db_xref="InterPro:IPR001330"
/db_xref="InterPro:IPR008930"
/db_xref="InterPro:IPR032696"
/db_xref="UniProtKB/Swiss-Prot:O50406"
BEGIN
1 METFRTLLAK AALGNGISST AYDTAWVAKL GQLDDELSDL ALNWLCERQL PDGSWGAEFP
61 FCYEDRLLST LAAMISLTSN KHRRRRAAQV EKGLLALKNL TSGAFEGPQL DIKDATVGFE
121 LIAPTLMAEA ARLGLAICHE ESILGELVGV REQKLRKLGG SKINKHITAA FSVELAGQDG
181 VGMLDVDNLQ ETNGSVKYSP SASAYFALHV KPGDKRALAY ISSIIQAGDG GAPAFYQAEI
241 FEIVWSLWNL SRTDIDLSDP EIVRTYLPYL DHVEQHWVRG RGVGWTGNST LEDCDTTSVA
301 YDVLSKFGRS PDIGAVLQFE DADWFRTYFH EVGPSISTNV HVLGALKQAG YDKCHPRVRK
361 VLEFIRSSKE PGRFCWRDKW HRSAYYTTAH LICAASNYDD ALCSDAIGWI LNTQRPDGSW
421 GFFDGQATAE ETAYCIQALA HWQRHSGTSL SAQISRAGGW LSQHCEPPYA PLWIAKTLYC
481 SATVVKAAIL SALRLVDESN Q
//