LOCUS CCP46198.1 501 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Halimadienyl diphosphate synthase protein. ACCESSION AL123456-3476 PROTEIN_ID CCP46198.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /locus_tag="Rv3377c" /note="Rv3377c, (MTV004.35c), len: 501 aa. Halimadienyl diphosphate synthase; similarity with various proteins,notably cyclases involved in steroid biosynthesis in plants and bacteria e.g. BAB52679|MLR6369 from Rhizobium loti (Mesorhizobium loti) (516 aa), FASTA scores: opt: 533, E(): 5.6e-27, (30.45% identity in 522 aa overlap); Q9ZTN8 copalyl diphosphate synthase 1 from Cucurbita maxima (Pumpkin) (Winter squash) (823 aa), FASTA scores: opt: 484,E(): 1.2e-23, (28.35% identity in 388 aa overlap); Q38710|AC22 abietadiene cyclase from Abies grandis (868 aa), FASTA scores: opt: 382, E(): 5.2e-17, (25.55% identity in 462 aa overlap); Q41771|AN1 kaurene synthase a from Zea mays (Maize) (823 aa), FASTA scores: opt: 377, E(): 1.1e-16, (29.75% identity in 390 aa overlap); Q9AJE4 diterpene cyclase-1 from Kitasatospora griseola (Streptomyces griseolosporeus) (499 aa), FASTA scores: opt: 336, E(): 3.2e-14, (27.5% identity in 513 aa overlap); Q9SAU6 E-alpha-bisabolene synthase (fragment) from Abies grandis (782 aa), FASTA scores: opt: 317, E(): 7.8e-13,(25.25% identity in 479 aa overlap); etc. Note that this and the upstream ORF MTV004.36c have a significantly lower GC bias than the rest of the genome. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). Cofactor: Mg2+." /db_xref="EnsemblGenomes-Gn:Rv3377c" /db_xref="EnsemblGenomes-Tr:CCP46198" /db_xref="GOA:O50406" /db_xref="InterPro:IPR001330" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR032696" /db_xref="UniProtKB/Swiss-Prot:O50406" BEGIN 1 METFRTLLAK AALGNGISST AYDTAWVAKL GQLDDELSDL ALNWLCERQL PDGSWGAEFP 61 FCYEDRLLST LAAMISLTSN KHRRRRAAQV EKGLLALKNL TSGAFEGPQL DIKDATVGFE 121 LIAPTLMAEA ARLGLAICHE ESILGELVGV REQKLRKLGG SKINKHITAA FSVELAGQDG 181 VGMLDVDNLQ ETNGSVKYSP SASAYFALHV KPGDKRALAY ISSIIQAGDG GAPAFYQAEI 241 FEIVWSLWNL SRTDIDLSDP EIVRTYLPYL DHVEQHWVRG RGVGWTGNST LEDCDTTSVA 301 YDVLSKFGRS PDIGAVLQFE DADWFRTYFH EVGPSISTNV HVLGALKQAG YDKCHPRVRK 361 VLEFIRSSKE PGRFCWRDKW HRSAYYTTAH LICAASNYDD ALCSDAIGWI LNTQRPDGSW 421 GFFDGQATAE ETAYCIQALA HWQRHSGTSL SAQISRAGGW LSQHCEPPYA PLWIAKTLYC 481 SATVVKAAIL SALRLVDESN Q //