LOCUS CCP45376.1 423 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable histidyl-tRNA
synthetase HisS (histidine--tRNA ligase) (HISRS) (histidine-
-translase) protein.
ACCESSION AL123456-2654
PROTEIN_ID CCP45376.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="hisS"
/locus_tag="Rv2580c"
/note="Rv2580c, (MT2657, MTCY227.21), len: 423 aa.
Probable hisS, histidyl-tRNA synthetase, equivalent to
P46696|SYH_MYCLE|hiss|ML0494|MLCB1259.12|B1177_C3_248
histidyl-tRNA synthetase from Mycobacterium leprae (427
aa), FASTA scores: opt: 2380, E(): 2.1e-131, (85.85%
identity in 417 aa overlap). Also highly similar to many
e.g. Q9KXP2|hiss from Streptomyces coelicolor (425
aa),FASTA scores: opt: 1542, E(): 1.4e-82, (56.0% identity
in 418 aa overlap); O32422|SYH_STAAU|hiss from
Staphylococcus aureus (420 aa), FASTA scores: opt: 1135,
E(): 7.4e-59,(44.9% identity in 412 aa overlap);
P04804|SYH_ECOLI|hiss|B2514 from Escherichia coli strain
K12 (423 aa), FASTA scores: opt: 1099, E(): 9.4e-57,
(43.9% identity in 417 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to class-II
aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2580c"
/db_xref="EnsemblGenomes-Tr:CCP45376"
/db_xref="GOA:P9WFV5"
/db_xref="InterPro:IPR004154"
/db_xref="InterPro:IPR004516"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR015807"
/db_xref="InterPro:IPR033656"
/db_xref="InterPro:IPR036621"
/db_xref="InterPro:IPR041715"
/db_xref="UniProtKB/Swiss-Prot:P9WFV5"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MTEFSSFSAP KGVPDYVPPD SAQFVAVRDG LLAAARQAGY SHIELPIFED TALFARGVGE
61 STDVVSKEMY TFADRGDRSV TLRPEGTAGV VRAVIEHGLD RGALPVKLCY AGPFFRYERP
121 QAGRYRQLQQ VGVEAIGVDD PALDAEVIAI ADAGFRSLGL DGFRLEITSL GDESCRPQYR
181 ELLQEFLFGL DLDEDTRRRA GINPLRVLDD KRPELRAMTA SAPVLLDHLS DVAKQHFDTV
241 LAHLDALGVP YVINPRMVRG LDYYTKTAFE FVHDGLGAQS GIGGGGRYDG LMHQLGGQDL
301 SGIGFGLGVD RTVLALRAEG KTAGDSARCD VFGVPLGEAA KLRLAVLAGR LRAAGVRVDL
361 AYGDRGLKGA MRAAARSGAR VALVAGDRDI EAGTVAVKDL TTGEQVSVSM DSVVAEVISR
421 LAG
//