LOCUS       CCP45376.1               423 aa    PRT              BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv Probable histidyl-tRNA
            synthetase HisS (histidine--tRNA ligase) (HISRS) (histidine-
            -translase) protein.
ACCESSION   AL123456-2654
PROTEIN_ID  CCP45376.1
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
            Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
            Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
            Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
            Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
            Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
            Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
            Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
            Barrell B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393(6685), 537-544(1998).
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   2
  AUTHORS   Camus J.C., Pryor M.J., Medigue C., Cole S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91(1), 1-7(2011).
   PUBMED   20980199
REFERENCE   4  (bases 1 to 4411529)
  AUTHORS   Parkhill J.
  JOURNAL   Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
            Mycobacterium tuberculosis sequencing and mapping teams, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
            Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
            rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
            parkhill@sanger.ac.uk
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew J.M.
  JOURNAL   Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
            Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
            Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
            4, SWITZERLAND
COMMENT     On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971.
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:83332"
     protein         /transl_table=11
                     /gene="hisS"
                     /locus_tag="Rv2580c"
                     /note="Rv2580c, (MT2657, MTCY227.21), len: 423 aa.
                     Probable hisS, histidyl-tRNA synthetase, equivalent to
                     P46696|SYH_MYCLE|hiss|ML0494|MLCB1259.12|B1177_C3_248
                     histidyl-tRNA synthetase from Mycobacterium leprae (427
                     aa), FASTA scores: opt: 2380, E(): 2.1e-131, (85.85%
                     identity in 417 aa overlap). Also highly similar to many
                     e.g. Q9KXP2|hiss from Streptomyces coelicolor (425
                     aa),FASTA scores: opt: 1542, E(): 1.4e-82, (56.0% identity
                     in 418 aa overlap); O32422|SYH_STAAU|hiss from
                     Staphylococcus aureus (420 aa), FASTA scores: opt: 1135,
                     E(): 7.4e-59,(44.9% identity in 412 aa overlap);
                     P04804|SYH_ECOLI|hiss|B2514 from Escherichia coli strain
                     K12 (423 aa), FASTA scores: opt: 1099, E(): 9.4e-57,
                     (43.9% identity in 417 aa overlap); etc. Contains PS00017
                     ATP/GTP-binding site motif A (P-loop). Belongs to class-II
                     aminoacyl-tRNA synthetase family."
                     /db_xref="EnsemblGenomes-Gn:Rv2580c"
                     /db_xref="EnsemblGenomes-Tr:CCP45376"
                     /db_xref="GOA:P9WFV5"
                     /db_xref="InterPro:IPR004154"
                     /db_xref="InterPro:IPR004516"
                     /db_xref="InterPro:IPR006195"
                     /db_xref="InterPro:IPR015807"
                     /db_xref="InterPro:IPR033656"
                     /db_xref="InterPro:IPR036621"
                     /db_xref="InterPro:IPR041715"
                     /db_xref="UniProtKB/Swiss-Prot:P9WFV5"
                     /inference="protein motif:PROSITE:PS00017"
                     /experiment="EXISTENCE: identified in proteomics study"
BEGIN
        1 MTEFSSFSAP KGVPDYVPPD SAQFVAVRDG LLAAARQAGY SHIELPIFED TALFARGVGE
       61 STDVVSKEMY TFADRGDRSV TLRPEGTAGV VRAVIEHGLD RGALPVKLCY AGPFFRYERP
      121 QAGRYRQLQQ VGVEAIGVDD PALDAEVIAI ADAGFRSLGL DGFRLEITSL GDESCRPQYR
      181 ELLQEFLFGL DLDEDTRRRA GINPLRVLDD KRPELRAMTA SAPVLLDHLS DVAKQHFDTV
      241 LAHLDALGVP YVINPRMVRG LDYYTKTAFE FVHDGLGAQS GIGGGGRYDG LMHQLGGQDL
      301 SGIGFGLGVD RTVLALRAEG KTAGDSARCD VFGVPLGEAA KLRLAVLAGR LRAAGVRVDL
      361 AYGDRGLKGA MRAAARSGAR VALVAGDRDI EAGTVAVKDL TTGEQVSVSM DSVVAEVISR
      421 LAG
//