LOCUS CAA75069.1 244 aa PRT HUM 14-NOV-2006
DEFINITION Homo sapiens lymphotoxin-beta protein.
ACCESSION Y14768-10
PROTEIN_ID CAA75069.1
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 2 (bases 1 to 81800)
AUTHORS Neville M.J.
JOURNAL Submitted (05-SEP-1997) to the INSDC. M.J. Neville, University of
Oxford, MRC Immunochemistry Unit, Department of Biochemistry, South
Parks Road, Oxford OX1 3QU, UK
REFERENCE 3
AUTHORS Iris F., Bougueleret L., Prieur S., Caterina D., Primas G.,
Perrot V., Jurka J., Rodriguez-Tome P., Claverie J., Cohen D.,
Dausset J.
TITLE Dense Alu clustering and a potential new member of the NF kappa B
family within a 90 kilobase HLA class III segment
JOURNAL Nat Genet 3(2), 137-145(1993).
PUBMED 8499947
REFERENCE 4
AUTHORS Utans U., Quist W.C., McManus B.M., Wilson J.E., Arceci R.J.,
Wallace A.F., Russell M.E.
TITLE Allograft inflammatory factory-1. A cytokine-responsive macrophage
molecule expressed in transplanted human hearts
JOURNAL Transplantation 61(9), 1387-1392(1996).
PUBMED 8629302
REFERENCE 5
AUTHORS Holzinger I., de Baey A., Messer G., Kick G., Zwierzina H.,
Weiss E.H.
TITLE Cloning and genomic characterization of LST1: a new gene in the
human TNF region
JOURNAL Immunogenetics 42(5), 315-322(1995).
PUBMED 7590964
REFERENCE 6
AUTHORS Browning J.L., Ngam-ek A., Lawton P., DeMarinis J., Tizard R.,
Chow E.P., Hession C., O'Brine-Greco B., Foley S.F., Ware C.F.
TITLE Lymphotoxin beta, a novel member of the TNF family that forms a
heteromeric complex with lymphotoxin on the cell surface
JOURNAL Cell 72(6), 847-856(1993).
PUBMED 7916655
REFERENCE 7
AUTHORS Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D.,
Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W.
TITLE Human lymphotoxin and tumor necrosis factor genes: structure,
homology and chromosomal localization
JOURNAL Nucleic Acids Res. 13(17), 6361-6373(1985).
PUBMED 2995927
REFERENCE 8
AUTHORS Messer G., Spengler U., Jung M.C., Honold G., Bloemer K.,
Pape G.R., Riethmueller G., Weiss E.H.
TITLE Polymorphic structure of the tumor necrosis factor (TNF) locus: an
NcoI polymorphism in the first intron of the human TNF-beta gene
correlates with a variant amino acid in position 26 and a reduced
level of TNF-beta production
JOURNAL J. Exp. Med. 173(1), 209-219(1991).
PUBMED 1670638
REFERENCE 9
AUTHORS Abraham L.J., Du D.C., Zahedi K., Dawkins R.L., Whitehead A.S.
TITLE Haplotypic polymorphisms of the TNFB gene
JOURNAL Immunogenetics 33(1), 50-53(1991).
PUBMED 1671667
REFERENCE 10
AUTHORS Albertella M.R., Campbell D.R.
TITLE Characterization of a novel gene in the human major
histocompatibility complex that encodes a potential new member of
the I kappa B family of proteins
JOURNAL Hum. Mol. Genet. 3(5), 793-799(1994).
PUBMED 8081366
REFERENCE 11
AUTHORS Peelman L., Chardon P., Nunes M., Renard C., Geffrotin C.,
Vaiman M., Van Zeveren A., Coppieters W., Van de Weghe A.,
Bouquet Y., Choy W., Strominger J., Spies T.
TITLE The BAT1 gene in the MHC encodes an evolutionarily conserved
putative nuclear RNA helicase of the DEAD family
JOURNAL Genomics 26(2), 210-218(1995).
PUBMED 7601445
REFERENCE 12
AUTHORS Neville M.J., Campbell R.D.
TITLE Alternative splicing of the LST-1 gene located in the Major
Histocompatibility Complex on human chromosome 6
JOURNAL DNA Seq 8(3), 155-160(1997).
PUBMED 10668961
REFERENCE 13
AUTHORS de Baey A., Fellerhoff B., Maier S., Martinozzi S., Weidle U.,
Weiss E.H.
TITLE Complex expression pattern of the TNF region gene LST1 through
differential regulation, initiation, and alternative splicing
JOURNAL Genomics 45(3), 591-600(1997).
PUBMED 9367684
REFERENCE 14
AUTHORS Shiina T., Tamiya G., Oka A., Yamagata T., Yamagata N., Kikkawa E.,
Goto K., Mizuki N., Watanabe K., Fukuzumi Y., Taguchi S.,
Sugawara C., Ono A., Chen L., Yamazaki M., Tashiro H., Ando A.,
Ikemura T., Kimura M., Inoko H.
TITLE Nucleotide sequencing analysis of the 146-kilobase segment around
the IkBL and MICA genes at the centromeric end of the HLA class I
region
JOURNAL Genomics 47(3), 372-382(1998).
PUBMED 9480751
REFERENCE 15
AUTHORS Neville M.J., Milner C.M., Campbell R.D.
TITLE A new member of the immunoglobulin superfamily and a V-ATPase G
subunit are amongst the predicted products of novel genes close to
the TNF locus in the human MHC
JOURNAL Unpublished.
COMMENT Related publications:
1) Olavesen M.G., Proc. 11th Intl. Histocompatibility workshop &
conference 2,190-193 (1991)
2) Nalabolu S.R., Genomics 31,215-222 (1996)
FEATURES Qualifiers
source /organism="Homo sapiens"
/chromosome="6"
/map="p21.3"
/lab_host="E.coli (NM554)"
/mol_type="genomic DNA"
/haplotype="HLA A2,B7,DR2,C2c,BFs,C4A 3,C4B QO"
/clone_lib="MboI cut genomic DNA cloned into PDVCOS cosmid
vector"
/clone="TN62"
/clone="TN82"
/sub_clone="M13mp18"
/cell_line="EBV transformed lymphoblastoid cell line"
/cell_type="lymphoblastoid"
/db_xref="taxon:9606"
protein /gene="LTB"
/db_xref="GOA:Q06643"
/db_xref="HGNC:HGNC:6711"
/db_xref="InterPro:IPR002961"
/db_xref="InterPro:IPR006052"
/db_xref="InterPro:IPR006053"
/db_xref="InterPro:IPR008983"
/db_xref="InterPro:IPR021184"
/db_xref="PDB:4MXW"
/db_xref="UniProtKB/Swiss-Prot:Q06643"
intron_pos 55:0 (1/3)
intron_pos 70:1 (2/3)
intron_pos 94:1 (3/3)
BEGIN
1 MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTETAD
61 PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ GLGWETTKEQ AFLTSGTQFS
121 DAEGLALPQD GLYYLYCLVG YRGRAPPGGG DPQGRSVTLR SSLYRAGGAY GPGTPELLLE
181 GAETVTPVLD PARRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA
241 VMVG
//