LOCUS CAA75069.1 244 aa PRT HUM 14-NOV-2006 DEFINITION Homo sapiens lymphotoxin-beta protein. ACCESSION Y14768-10 PROTEIN_ID CAA75069.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 2 (bases 1 to 81800) AUTHORS Neville M.J. JOURNAL Submitted (05-SEP-1997) to the INSDC. M.J. Neville, University of Oxford, MRC Immunochemistry Unit, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK REFERENCE 3 AUTHORS Iris F., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V., Jurka J., Rodriguez-Tome P., Claverie J., Cohen D., Dausset J. TITLE Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment JOURNAL Nat Genet 3(2), 137-145(1993). PUBMED 8499947 REFERENCE 4 AUTHORS Utans U., Quist W.C., McManus B.M., Wilson J.E., Arceci R.J., Wallace A.F., Russell M.E. TITLE Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts JOURNAL Transplantation 61(9), 1387-1392(1996). PUBMED 8629302 REFERENCE 5 AUTHORS Holzinger I., de Baey A., Messer G., Kick G., Zwierzina H., Weiss E.H. TITLE Cloning and genomic characterization of LST1: a new gene in the human TNF region JOURNAL Immunogenetics 42(5), 315-322(1995). PUBMED 7590964 REFERENCE 6 AUTHORS Browning J.L., Ngam-ek A., Lawton P., DeMarinis J., Tizard R., Chow E.P., Hession C., O'Brine-Greco B., Foley S.F., Ware C.F. TITLE Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface JOURNAL Cell 72(6), 847-856(1993). PUBMED 7916655 REFERENCE 7 AUTHORS Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D., Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W. TITLE Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization JOURNAL Nucleic Acids Res. 13(17), 6361-6373(1985). PUBMED 2995927 REFERENCE 8 AUTHORS Messer G., Spengler U., Jung M.C., Honold G., Bloemer K., Pape G.R., Riethmueller G., Weiss E.H. TITLE Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production JOURNAL J. Exp. Med. 173(1), 209-219(1991). PUBMED 1670638 REFERENCE 9 AUTHORS Abraham L.J., Du D.C., Zahedi K., Dawkins R.L., Whitehead A.S. TITLE Haplotypic polymorphisms of the TNFB gene JOURNAL Immunogenetics 33(1), 50-53(1991). PUBMED 1671667 REFERENCE 10 AUTHORS Albertella M.R., Campbell D.R. TITLE Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins JOURNAL Hum. Mol. Genet. 3(5), 793-799(1994). PUBMED 8081366 REFERENCE 11 AUTHORS Peelman L., Chardon P., Nunes M., Renard C., Geffrotin C., Vaiman M., Van Zeveren A., Coppieters W., Van de Weghe A., Bouquet Y., Choy W., Strominger J., Spies T. TITLE The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family JOURNAL Genomics 26(2), 210-218(1995). PUBMED 7601445 REFERENCE 12 AUTHORS Neville M.J., Campbell R.D. TITLE Alternative splicing of the LST-1 gene located in the Major Histocompatibility Complex on human chromosome 6 JOURNAL DNA Seq 8(3), 155-160(1997). PUBMED 10668961 REFERENCE 13 AUTHORS de Baey A., Fellerhoff B., Maier S., Martinozzi S., Weidle U., Weiss E.H. TITLE Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing JOURNAL Genomics 45(3), 591-600(1997). PUBMED 9367684 REFERENCE 14 AUTHORS Shiina T., Tamiya G., Oka A., Yamagata T., Yamagata N., Kikkawa E., Goto K., Mizuki N., Watanabe K., Fukuzumi Y., Taguchi S., Sugawara C., Ono A., Chen L., Yamazaki M., Tashiro H., Ando A., Ikemura T., Kimura M., Inoko H. TITLE Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region JOURNAL Genomics 47(3), 372-382(1998). PUBMED 9480751 REFERENCE 15 AUTHORS Neville M.J., Milner C.M., Campbell R.D. TITLE A new member of the immunoglobulin superfamily and a V-ATPase G subunit are amongst the predicted products of novel genes close to the TNF locus in the human MHC JOURNAL Unpublished. COMMENT Related publications: 1) Olavesen M.G., Proc. 11th Intl. Histocompatibility workshop & conference 2,190-193 (1991) 2) Nalabolu S.R., Genomics 31,215-222 (1996) FEATURES Qualifiers source /organism="Homo sapiens" /chromosome="6" /map="p21.3" /lab_host="E.coli (NM554)" /mol_type="genomic DNA" /haplotype="HLA A2,B7,DR2,C2c,BFs,C4A 3,C4B QO" /clone_lib="MboI cut genomic DNA cloned into PDVCOS cosmid vector" /clone="TN62" /clone="TN82" /sub_clone="M13mp18" /cell_line="EBV transformed lymphoblastoid cell line" /cell_type="lymphoblastoid" /db_xref="taxon:9606" protein /gene="LTB" /db_xref="GOA:Q06643" /db_xref="HGNC:HGNC:6711" /db_xref="InterPro:IPR002961" /db_xref="InterPro:IPR006052" /db_xref="InterPro:IPR006053" /db_xref="InterPro:IPR008983" /db_xref="InterPro:IPR021184" /db_xref="PDB:4MXW" /db_xref="UniProtKB/Swiss-Prot:Q06643" intron_pos 55:0 (1/3) intron_pos 70:1 (2/3) intron_pos 94:1 (3/3) BEGIN 1 MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTETAD 61 PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ GLGWETTKEQ AFLTSGTQFS 121 DAEGLALPQD GLYYLYCLVG YRGRAPPGGG DPQGRSVTLR SSLYRAGGAY GPGTPELLLE 181 GAETVTPVLD PARRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA 241 VMVG //