LOCUS CAA04137.1 237 aa PRT HUM 14-NOV-2006 DEFINITION Homo sapiens tyrosinase-related protein-2 protein. ACCESSION AJ000503-1 PROTEIN_ID CAA04137.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Lupetti R. JOURNAL Submitted (18-JUL-1997) to the INSDC. Lupetti R., Experimental Oncology D, Istituto Nazionale Tumori, via Venezian, 1, 20133 Milano, ITALY. REMARK Revised by [4] REFERENCE 2 AUTHORS Yokoyama K., Suzuki H., Yasumoto K., Tomita Y., Shibahara S. TITLE Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2 JOURNAL Biochim. Biophys. Acta 1217(3), 317-321(1994). PUBMED 8148378 REFERENCE 3 AUTHORS Sturm R.A., O'Sullivan B.J., Box N.F., Smith A.G., Smit S.E., Puttick E.R., Parsons P.G., Dunn I.S. TITLE Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family JOURNAL Genomics 29(1), 24-34(1995). PUBMED 8530077 REFERENCE 4 (bases 1 to 3525) AUTHORS Lupetti R. JOURNAL Submitted (10-JUL-1998) to the INSDC. Lupetti R., Experimental Oncology D, Istituto Nazionale Tumori, via Venezian, 1, 20133 Milano, ITALY. REFERENCE 5 AUTHORS Lupetti R., Pisarra P., Verrecchia A., Farina C., Nicolini G., Anichini A., Bordignon C., Sensi M.L., Parmiani G., Traversari C. TITLE Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage JOURNAL J. Exp. Med. 188(6), 1005-1016(1998). PUBMED 9743519 FEATURES Qualifiers source /db_xref="H-InvDB:HIT000243811" /organism="Homo sapiens" /chromosome="13" /map="q3" /isolate="patient 18732" /mol_type="mRNA" /dev_stage="adult" /cell_line="Me18732" /cell_type="melanoma" /tissue_type="lymphonode metastasis" /db_xref="taxon:9606" protein /gene="TRP-2" /function="DOPAchrome tautomerase" /EC_number="5.3.3.12" /note="This translation product contains a sequence (aa 200-237) derived from the retained intron 2 of the partially spliced TRP-2 mRNA. Aminoacids 222-231 code for a 10-mer which is a shared melanoma antigen recognized by cytotoxic T lymphocytes." /db_xref="GOA:O75767" /db_xref="H-InvDB:HIT000243811.14" /db_xref="InterPro:IPR008922" /db_xref="UniProtKB/TrEMBL:O75767" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN VCGSQQGRGQ 61 CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER 121 KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWVGLLGPN GTQPQFANCS 181 VYDFFVWLHY YSVRDTLLGG FFPWLKVYYY RFVIGLRVWQ WEVISCKLIK RATTRQP //