LOCUS       CAA04137.1               237 aa    PRT              HUM 14-NOV-2006
DEFINITION  Homo sapiens tyrosinase-related protein-2 protein.
ACCESSION   AJ000503-1
PROTEIN_ID  CAA04137.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Lupetti R.
  JOURNAL   Submitted (18-JUL-1997) to the INSDC. Lupetti R., Experimental
            Oncology D, Istituto Nazionale Tumori, via Venezian, 1, 20133
            Milano, ITALY.
  REMARK    Revised by [4]
REFERENCE   2
  AUTHORS   Yokoyama K., Suzuki H., Yasumoto K., Tomita Y., Shibahara S.
  TITLE     Molecular cloning and functional analysis of a cDNA coding for
            human DOPAchrome tautomerase/tyrosinase-related protein-2
  JOURNAL   Biochim. Biophys. Acta 1217(3), 317-321(1994).
   PUBMED   8148378
REFERENCE   3
  AUTHORS   Sturm R.A., O'Sullivan B.J., Box N.F., Smith A.G., Smit S.E.,
            Puttick E.R., Parsons P.G., Dunn I.S.
  TITLE     Chromosomal structure of the human TYRP1 and TYRP2 loci and
            comparison of the tyrosinase-related protein gene family
  JOURNAL   Genomics 29(1), 24-34(1995).
   PUBMED   8530077
REFERENCE   4  (bases 1 to 3525)
  AUTHORS   Lupetti R.
  JOURNAL   Submitted (10-JUL-1998) to the INSDC. Lupetti R., Experimental
            Oncology D, Istituto Nazionale Tumori, via Venezian, 1, 20133
            Milano, ITALY.
REFERENCE   5
  AUTHORS   Lupetti R., Pisarra P., Verrecchia A., Farina C., Nicolini G.,
            Anichini A., Bordignon C., Sensi M.L., Parmiani G., Traversari C.
  TITLE     Translation of a retained intron in tyrosinase-related protein
            (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined
            and shared human melanoma antigen not expressed in normal cells of
            the melanocytic lineage
  JOURNAL   J. Exp. Med. 188(6), 1005-1016(1998).
   PUBMED   9743519
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000243811"
                     /organism="Homo sapiens"
                     /chromosome="13"
                     /map="q3"
                     /isolate="patient 18732"
                     /mol_type="mRNA"
                     /dev_stage="adult"
                     /cell_line="Me18732"
                     /cell_type="melanoma"
                     /tissue_type="lymphonode metastasis"
                     /db_xref="taxon:9606"
     protein         /gene="TRP-2"
                     /function="DOPAchrome tautomerase"
                     /EC_number="5.3.3.12"
                     /note="This translation product contains a sequence (aa
                     200-237) derived from the retained intron 2 of the
                     partially spliced TRP-2 mRNA. Aminoacids 222-231 code for
                     a 10-mer which is a shared melanoma antigen recognized by
                     cytotoxic T lymphocytes."
                     /db_xref="GOA:O75767"
                     /db_xref="H-InvDB:HIT000243811.14"
                     /db_xref="InterPro:IPR008922"
                     /db_xref="UniProtKB/TrEMBL:O75767"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN VCGSQQGRGQ
       61 CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER
      121 KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWVGLLGPN GTQPQFANCS
      181 VYDFFVWLHY YSVRDTLLGG FFPWLKVYYY RFVIGLRVWQ WEVISCKLIK RATTRQP
//