LOCUS AAC77828.1 550 aa PRT HUM 16-OCT-2000
DEFINITION Homo sapiens iduronate 2-sulfatase protein.
ACCESSION AF011889-1
PROTEIN_ID AAC77828.1
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 195603 to 325470)
AUTHORS Timms,K.M., Lu,F., Shen,Y., Pierson,C.A., Muzny,D.M., Gu,Y.,
Nelson,D.L. and Gibbs,R.A.
TITLE 130 kb of DNA sequence reveals two new genes and a regional
duplication distal to the human iduronate-2-sulfate sulfatase locus
JOURNAL Genome Res. 5 (1), 71-78 (1995)
PUBMED 8717057
REFERENCE 2 (bases 120609 to 326663)
AUTHORS Timms,K.M., Bondeson,M.L., Ansari-Lari,M.A., Lagerstedt,K.,
Muzny,D.M., Dugan-Rocha,S.P., Nelson,D.L., Pettersson,U. and
Gibbs,R.A.
TITLE Molecular and phenotypic variation in patients with severe Hunter
syndrome
JOURNAL Hum. Mol. Genet. 6 (3), 479-486 (1997)
PUBMED 9147653
REFERENCE 3 (bases 27820 to 69003)
AUTHORS Gerken,S.C., Matsunami,N., Plaetke,R., Albertsen,H., Ballard,L.,
Melis,R., Lawrence,E., Moore,M., Holik,P.R., Carlson,M., Zhao,X.,
Robertson,M., Bradlely,P., Elsner,T., Tingey,A., Lalouel,J.-M. and
White,R.
TITLE Genetic and physical mapping of simple sequence repeat containing
sequence tagged sites from the human genome
JOURNAL Unpublished
REFERENCE 4 (bases 1 to 326663)
AUTHORS Muzny,D., Ansari-Lari,M.A., Timms,K.M., Yu,W., Dugan,S., Lu,J.,
Shen,Y., Rowland,K., Liu,W., Perez,L., Ding,Y., Gonzalez,O.,
Haywood,M., Jain,A., Leal,B., Logan,O., Nguyen,V., Savage,L.,
Shen,H., Worley,K., Chen,E., Forcum,J., Arenson,A.D., Chiu,M.W.,
Gorrell,J.H., Brundage,E., Di,W., Chinault,C., Nelson,D. and
Gibbs,R.A.
JOURNAL Unpublished
REFERENCE 5 (bases 1 to 326663)
AUTHORS Chiu,M.W.
TITLE Direct Submission
JOURNAL Submitted (27-JUN-1997) Molecular and Human Genetics, Baylor
College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
REFERENCE 6 (bases 1 to 326663)
AUTHORS Gorrell,L.L.
TITLE Direct Submission
JOURNAL Submitted (17-NOV-1998) Human Genome Sequencing Center, Baylor
College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
COMMENT On or before Oct 16, 2000 this sequence version replaced L35485.1,
gi:1710997, gi:1519282.
Sequencing is completed to a minimum standard of double strand
coverage or two chemistries on at least two separate clones, with
three overlapping reads. If sequence quality does not meet this
standard, it will be indicated in the annotation.
The repeat regions shown were identified using RepeatMasker by
Adrian Smit.
Sequence similarities were identified using Powerblast by Jinghui
Zhang.
Exon/Intron boundaries of identified genes were chosen if there
were canonical splice junctions that maintained sequence continuity
across the splice junctions.
FEATURES Qualifiers
source /organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq28"
/clone="U126G1, U142F2, U69B6, U145C10, U169A5, U84H1,
U24D12, U80A7, U153E6, R7-163A8"
/clone_lib="LLNL X chromosome library LLOXNC01"
protein /gene="IDS"
/db_xref="GDB:120521"
intron_pos 35:1 (1/8)
intron_pos 81:0 (2/8)
intron_pos 140:1 (3/8)
intron_pos 170:0 (4/8)
intron_pos 237:0 (5/8)
intron_pos 294:0 (6/8)
intron_pos 336:1 (7/8)
intron_pos 394:1 (8/8)
BEGIN
1 MPPPRTGRGL LWLGLVLSSV CVALGSETQA NSTTDALNVL LIIVDDLRPS LGCYGDKLVR
61 SPNIDQLASH SLLFQNAFAQ QAVCAPSRVS FLTGRRPDTT RLYDFNSYWR VHAGNFSTIP
121 QYFKENGYVT MSVGKVFHPG ISSNHTDDSP YSWSFPPYHP SSEKYENTKT CRGPDGELHA
181 NLLCPVDVLD VPEGTLPDKQ STEQAIQLLE KMKTSASPFF LAVGYHKPHI PFRYPKEFQK
241 LYPLENITLA PDPEVPDGLP PVAYNPWMDI RQREDVQALN ISVPYGPIPV DFQRKIRQSY
301 FASVSYLDTQ VGRLLSALDD LQLANSTIIA FTSDHGWALG EHGEWAKYSN FDVATHVPLI
361 FYVPGRTASL PEAGEKLFPY LDPFDSASQL MEPGRQSMDL VELVSLFPTL AGLAGLQVPP
421 RCPVPSFHVE LCREGKNLLK HFRFRDLEED PYLPGNPREL IAYSQYPRPS DIPQWNSDKP
481 SLKDIKIMGY SIRTIDYRYT VWVGFNPDEF LANFSDIHAG ELYFVDSDPL QDHNMYNDSQ
541 GGDLFQLLMP
//