LOCUS       AAC77828.1               550 aa    PRT              HUM 16-OCT-2000
DEFINITION  Homo sapiens iduronate 2-sulfatase protein.
ACCESSION   AF011889-1
PROTEIN_ID  AAC77828.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 195603 to 325470)
  AUTHORS   Timms,K.M., Lu,F., Shen,Y., Pierson,C.A., Muzny,D.M., Gu,Y.,
            Nelson,D.L. and Gibbs,R.A.
  TITLE     130 kb of DNA sequence reveals two new genes and a regional
            duplication distal to the human iduronate-2-sulfate sulfatase locus
  JOURNAL   Genome Res. 5 (1), 71-78 (1995)
   PUBMED   8717057
REFERENCE   2  (bases 120609 to 326663)
  AUTHORS   Timms,K.M., Bondeson,M.L., Ansari-Lari,M.A., Lagerstedt,K.,
            Muzny,D.M., Dugan-Rocha,S.P., Nelson,D.L., Pettersson,U. and
            Gibbs,R.A.
  TITLE     Molecular and phenotypic variation in patients with severe Hunter
            syndrome
  JOURNAL   Hum. Mol. Genet. 6 (3), 479-486 (1997)
   PUBMED   9147653
REFERENCE   3  (bases 27820 to 69003)
  AUTHORS   Gerken,S.C., Matsunami,N., Plaetke,R., Albertsen,H., Ballard,L.,
            Melis,R., Lawrence,E., Moore,M., Holik,P.R., Carlson,M., Zhao,X.,
            Robertson,M., Bradlely,P., Elsner,T., Tingey,A., Lalouel,J.-M. and
            White,R.
  TITLE     Genetic and physical mapping of simple sequence repeat containing
            sequence tagged sites from the human genome
  JOURNAL   Unpublished
REFERENCE   4  (bases 1 to 326663)
  AUTHORS   Muzny,D., Ansari-Lari,M.A., Timms,K.M., Yu,W., Dugan,S., Lu,J.,
            Shen,Y., Rowland,K., Liu,W., Perez,L., Ding,Y., Gonzalez,O.,
            Haywood,M., Jain,A., Leal,B., Logan,O., Nguyen,V., Savage,L.,
            Shen,H., Worley,K., Chen,E., Forcum,J., Arenson,A.D., Chiu,M.W.,
            Gorrell,J.H., Brundage,E., Di,W., Chinault,C., Nelson,D. and
            Gibbs,R.A.
  JOURNAL   Unpublished
REFERENCE   5  (bases 1 to 326663)
  AUTHORS   Chiu,M.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-JUN-1997) Molecular and Human Genetics, Baylor
            College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
REFERENCE   6  (bases 1 to 326663)
  AUTHORS   Gorrell,L.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-NOV-1998) Human Genome Sequencing Center, Baylor
            College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
COMMENT     On or before Oct 16, 2000 this sequence version replaced L35485.1,
            gi:1710997, gi:1519282.
            Sequencing is completed to a minimum standard of double strand
            coverage or two chemistries on at least two separate clones, with
            three overlapping reads.  If sequence quality does not meet this
            standard, it will be indicated in the annotation.
            The repeat regions shown were identified using RepeatMasker by
            Adrian Smit.
            Sequence similarities were identified using Powerblast by Jinghui
            Zhang.
            Exon/Intron boundaries of identified genes were chosen if there
            were canonical splice junctions that maintained sequence continuity
            across the splice junctions.
FEATURES             Qualifiers
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
                     /clone="U126G1, U142F2, U69B6, U145C10, U169A5, U84H1,
                     U24D12, U80A7, U153E6, R7-163A8"
                     /clone_lib="LLNL X chromosome library LLOXNC01"
     protein         /gene="IDS"
                     /db_xref="GDB:120521"
     intron_pos      35:1 (1/8)
     intron_pos      81:0 (2/8)
     intron_pos      140:1 (3/8)
     intron_pos      170:0 (4/8)
     intron_pos      237:0 (5/8)
     intron_pos      294:0 (6/8)
     intron_pos      336:1 (7/8)
     intron_pos      394:1 (8/8)
BEGIN
        1 MPPPRTGRGL LWLGLVLSSV CVALGSETQA NSTTDALNVL LIIVDDLRPS LGCYGDKLVR
       61 SPNIDQLASH SLLFQNAFAQ QAVCAPSRVS FLTGRRPDTT RLYDFNSYWR VHAGNFSTIP
      121 QYFKENGYVT MSVGKVFHPG ISSNHTDDSP YSWSFPPYHP SSEKYENTKT CRGPDGELHA
      181 NLLCPVDVLD VPEGTLPDKQ STEQAIQLLE KMKTSASPFF LAVGYHKPHI PFRYPKEFQK
      241 LYPLENITLA PDPEVPDGLP PVAYNPWMDI RQREDVQALN ISVPYGPIPV DFQRKIRQSY
      301 FASVSYLDTQ VGRLLSALDD LQLANSTIIA FTSDHGWALG EHGEWAKYSN FDVATHVPLI
      361 FYVPGRTASL PEAGEKLFPY LDPFDSASQL MEPGRQSMDL VELVSLFPTL AGLAGLQVPP
      421 RCPVPSFHVE LCREGKNLLK HFRFRDLEED PYLPGNPREL IAYSQYPRPS DIPQWNSDKP
      481 SLKDIKIMGY SIRTIDYRYT VWVGFNPDEF LANFSDIHAG ELYFVDSDPL QDHNMYNDSQ
      541 GGDLFQLLMP
//