LOCUS BC078657 6773 bp mRNA linear HUM 17-JUL-2006
DEFINITION Homo sapiens pregnancy-associated plasma protein A, pappalysin 1,
mRNA (cDNA clone MGC:87189 IMAGE:30340336), complete cds.
ACCESSION BC078657
VERSION BC078657.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6773)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 6773)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-AUG-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. Stefan Hansson
cDNA Library Preparation: Michael Brownstein / Ted Usdin
Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 168 Row: l Column: 16
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 38045914.
FEATURES Location/Qualifiers
source 1..6773
/db_xref="H-InvDB:HIT000265744"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:87189 IMAGE:30340336"
/tissue_type="Placenta, normal"
/clone_lib="NIH_MGC_147"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..6773
/gene="PAPPA"
/gene_synonym="ASBABP2"
/gene_synonym="DIPLA1"
/gene_synonym="IGFBP-4ase"
/gene_synonym="PAPA"
/gene_synonym="PAPP-A"
/gene_synonym="PAPPA1"
/db_xref="GeneID:5069"
/db_xref="HGNC:HGNC:8602"
/db_xref="MIM:176385"
CDS 12..4895
/gene="PAPPA"
/gene_synonym="ASBABP2"
/gene_synonym="DIPLA1"
/gene_synonym="IGFBP-4ase"
/gene_synonym="PAPA"
/gene_synonym="PAPP-A"
/gene_synonym="PAPPA1"
/codon_start=1
/product="pregnancy-associated plasma protein A,
pappalysin 1"
/protein_id="AAH78657.1"
/db_xref="GeneID:5069"
/db_xref="HGNC:HGNC:8602"
/db_xref="MIM:176385"
/translation="MRLWSWVLHLGLLSAALGCGLAERPRRARRDPRAGRPPRPAAGP
ATCATRAARGRRASPPPPPPPGGAWEAVRVPRRRQQREARGATEEPSPPSRALYFSGR
GEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYDKCSYISRDRGWVVGIHTI
SDQDNKDPRYFFSLKTDRARQVTTINAHRSYLPGQWVYLAATYDGQFMKLYVNGAQVA
TSGEQVGGIFSPLTQKCKVLMLGGSALNHNYRGYIEHFSLWKVARTQREILSDMETHG
AHTALPQLLLQENWDNVKHAWSPMKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDN
TEVIASYNQLSSFRQPKVVRYRVVNLYEDDHKNPTVTREQVDFQHHQLAEAFKQYNIS
WELDVLEVSNSSLRRRLILANCDISKIGDENCDPECNHTLTGHDGGDCRHLRHPAFVK
KQHNGVCDMDCNYERFNFDGGECCDPEITNVTQTCFDPDSPHRAYLDVNELKNILKLD
GSTHLNIFFAKSSEEELAGVATWPWDKEALMHLGGIVLNPSFYGMPGHTHTMIHEIGH
SLGLYHVFRGISEIQSCSDPCMETEPSFETGDLCNDTNPAPKHKSCGDPGPGNDTCGF
HSFFNTPYNNFMSYADDDCTDSFTPNQVARMHCYLDLVYQGWQPSRKPAPVALAPQVL
GHTTDSVTLEWFPPIDGHFFERELGSACHLCLEGRILVQYASNASSPMPCSPSGHWSP
REAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFLYPLVPESLTI
WVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLTIRLWDVGEEVYGIQIY
TLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPPLQMDVASILHLNRKFVDMDLN
LGSVYQYWVITISGTEESEPSPAVTYIHGSGYCGDGIIQKDQGEQCDDMNKINGDGCS
LFCRQEVSFNCIDEPSRCYFHDGDGVCEEFEQKTSIKDCGVYTPQGFLDQWASNASVS
HQDQQCPGWVIIGQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLAQTTFWLRA
YFSQPMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNNPLII
PVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSPAEQS
CVHFACEKTDCPELAVENAYLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTG
PSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQL
KGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCK
PGYHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNS
ECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCPD
GYAIGSECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALI
HCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRD
PQAQEHSRKDLQGYSHG"
BASE COUNT 1654 a 1894 c 1723 g 1502 t
ORIGIN
1 aaccgtcgga catgcggctc tggagttggg tgctgcacct ggggctgctg agcgccgcgc
61 tgggctgcgg gctggccgag cgtccccgcc gggcccggag agacccgcgg gccggccgac
121 ccccgcgccc cgccgccggc ccggccacct gcgccacccg ggcggcccgc ggccgccgcg
181 cctcgccgcc gccgccgccg ccgccgggcg gtgcctggga agccgtgcgc gtcccccggc
241 ggcggcagca gcgggaggcg aggggcgcca ccgaggagcc gagcccgccg agccgggcgc
301 tctatttcag cgggcgaggc gagcagctgc gcctccgggc cgacctcgag ctgccccggg
361 acgcgttcac gctgcaagtg tggctgcgag cggagggggg ccagaggtct ccggcagtga
421 tcacagggct gtatgacaaa tgttcttata tctcacgtga ccgaggatgg gtcgtgggca
481 ttcacaccat cagtgaccaa gacaacaaag acccacgcta ctttttctcc ttgaagacag
541 accgagcccg gcaagtgacc accatcaatg cccaccgcag ctacctccca ggccagtggg
601 tatacctagc tgccacctat gatgggcagt tcatgaagct ctatgtgaat ggtgcccagg
661 tggccacctc tggggaacaa gtgggtggca tattcagccc actgacccag aagtgcaaag
721 tgctcatgtt agggggcagt gccctgaatc acaactaccg gggctacatc gagcacttca
781 gtctgtggaa ggtggccagg actcagcggg agatactgtc tgacatggaa acccatggcg
841 cccacactgc tctacctcag ctcctcctcc aggagaactg ggacaatgtg aagcatgcct
901 ggtcccccat gaaggatggc agcagcccca aagtggaatt cagcaatgcc cacggctttc
961 tgctggacac gagtctggag cctcctctgt gtggacagac attgtgtgac aacacagagg
1021 tcattgccag ctacaatcag ctctcaagtt tccgccagcc caaggtggtg cgctaccgcg
1081 tggtcaacct ctatgaagat gatcataaga acccgacggt gacgcgcgag caggtggact
1141 tccagcacca tcagctggct gaggccttca agcaatacaa catctcctgg gagctggacg
1201 tgctggaggt gagcaactcc tctcttcgcc gccgcctcat cctggccaac tgtgacatca
1261 gcaagattgg ggatgagaac tgtgaccccg agtgcaacca cacgctgacg ggccacgacg
1321 gcggggattg ccgccacctg cgccaccctg ccttcgtgaa gaagcagcac aacggggtgt
1381 gtgacatgga ctgcaactat gaacggttca actttgatgg tggagagtgc tgtgaccctg
1441 aaatcaccaa tgtcactcag acttgctttg accccgactc tccacacaga gcctacttgg
1501 atgttaatga gctgaagaac attcttaaat tggatggatc aacacatctc aatattttct
1561 ttgcaaaatc ctcagaggag gagttggcag gagtagcaac ttggccatgg gacaaggagg
1621 ccctgatgca cttaggtggc attgtcttga acccatcttt ctatggcatg cctgggcaca
1681 cccacaccat gatccatgag attggtcaca gcctgggcct ctatcacgtc ttccgaggca
1741 tctcagaaat ccagtcctgc agtgacccct gcatggagac agagccctcc ttcgagactg
1801 gagacctctg caatgatacc aacccagccc ctaaacacaa gtcctgtggt gacccagggc
1861 caggaaatga cacctgtggc tttcatagct tcttcaacac tccttacaac aacttcatga
1921 gctatgcaga tgacgactgt acggactcct tcacgcccaa tcaagtcgcc agaatgcact
1981 gttacctgga cctggtctac cagggctggc agccctccag gaaaccagcg cctgttgccc
2041 tcgcccccca agttctgggc cacacaacgg actctgtgac actggagtgg ttcccaccta
2101 tagatggcca tttctttgaa agagaattgg gatcagcatg tcatctttgc ctggaaggga
2161 gaatcctggt gcagtatgct tccaacgctt cctccccaat gccctgcagc ccatcaggac
2221 actggagccc tcgtgaagca gaaggtcatc ctgatgttga acagccctgt aagtccagtg
2281 tccgcacctg gagcccaaat tcagctgtca acccacacac ggttcctcca gcctgccctg
2341 agcctcaagg ctgctacctc gagctggagt tcctctaccc cttggtccct gagtctctga
2401 ccatttgggt gacctttgtc tccactgact gggactctag tggagctgtc aatgacatca
2461 aactgttggc tgtcagtggg aagaacatct ccctgggtcc tcagaatgtc ttctgtgatg
2521 tcccactgac catcagactc tgggacgtgg gcgaggaggt gtatggcatc caaatctaca
2581 cgctggatga gcacctggag atcgatgctg ccatgttgac ctccactgca gacaccccac
2641 tctgtctaca gtgtaagccc ctgaagtata aggtggtccg ggaccctcct ctccagatgg
2701 atgtggcctc catcctacat ctcaatagga aattcgtaga catggatcta aatcttggca
2761 gtgtgtacca gtattgggtc ataactattt caggaactga agagagtgag ccatcacctg
2821 ctgtcacata catccatgga agtgggtact gtggcgatgg cattatacaa aaagaccaag
2881 gtgaacaatg cgacgacatg aataagatca atggtgatgg ctgctccctt ttctgccgac
2941 aagaagtctc cttcaattgt attgatgaac ccagccggtg ctatttccat gatggtgatg
3001 gggtatgtga ggagtttgaa caaaaaacca gcattaagga ctgtggtgtc tacacgcccc
3061 agggattcct ggatcagtgg gcatccaatg cttcagtatc tcatcaagac cagcaatgcc
3121 caggctgggt catcatcgga cagccagcag catcccaggt gtgtcgaacc aaggtgatag
3181 atctcagtga aggcatttcc cagcatgcct ggtacccttg caccatcagc tacccatatt
3241 cccagctggc tcagaccact ttttggctcc gggcgtattt ttctcaacca atggttgccg
3301 cagctgtcat tgtccacctg gtgacggatg ggacatatta tggggaccaa aagcaggaga
3361 ccatcagcgt gcagctgctt gataccaaag atcagagcca cgatctaggc ctccatgtcc
3421 tgagctgcag gaacaatccc ctgattatcc ctgtggtcca tgacctcagc cagcccttct
3481 accacagcca ggcggtacgt gtgagcttca gttcgcccct ggtcgccatc tcgggggtgg
3541 ccctccgttc cttcgacaac tttgaccccg tcaccctgag cagctgccag agaggggaga
3601 cctacagccc tgccgagcag agctgcgtgc acttcgcatg tgagaaaact gactgtccag
3661 agctggctgt ggagaatgct tatctcaatt gctccagcag cgaccgctac cacggtgccc
3721 agtgtactgt gagctgccgg acaggctacg tgctccagat acggcgggat gatgagctga
3781 tcaagagcca gacgggaccc agcgtcacag tgacctgtac agagggcaag tggaataagc
3841 aggtggcctg tgagccagtc gactgcagca tcccagatca ccatcaagtc tatgctgcct
3901 ccttctcctg ccctgagggc accacctttg gcagtcaatg ttccttccag tgccgtcacc
3961 ctgcacaatt gaaaggcaac aacagcctcc tgacctgcat ggaggatggg ctgtggtcct
4021 tcccagaggc cctgtgtgag ctcatgtgcc tcgctccacc ccctgtgccc aatgcagacc
4081 tccagaccgc ccggtgccga gagaataagc acaaggtggg ctccttctgc aaatacaaat
4141 gcaagcctgg ataccatgtg cctggatcct ctcggaagtc aaagaaacgg gccttcaaga
4201 ctcagtgtac ccaggatggc agctggcagg agggagcttg tgttcctgtg acctgtgacc
4261 cacctccacc aaaattccat gggctctacc agtgtactaa tggcttccag ttcaacagtg
4321 agtgtaggat caagtgtgaa gacagtgatg cctcccaggg acttgggagc aatgtcattc
4381 attgccggaa agatggcacc tggaacggct ccttccatgt ctgccaggag atgcaaggcc
4441 agtgctcggt tccaaacgag ctcaacagca acctcaaact gcagtgccct gatggctatg
4501 ccatagggtc ggagtgtgcc acctcgtgcc tggaccacaa cagcgagtcc atcatcctgc
4561 caatgaacgt gaccgtgcgt gacatccccc actggctgaa ccccacacgg gtagagagag
4621 ttgtctgcac tgctggtctc aagtggtatc ctcaccctgc tctgattcac tgtgtcaaag
4681 gctgtgagcc cttcatggga gacaattatt gtgatgccat caacaaccga gccttttgca
4741 actatgacgg tggggattgc tgcacctcca cagtgaagac caaaaaggtc accccattcc
4801 ctatgtcctg tgacctacaa ggtgactgtg cttgtcggga cccccaggcc caagaacaca
4861 gccggaaaga cctccaggga tacagccatg gctaaggaag gacaagaagt tgtcaaagaa
4921 ttcccaacgc caggacccac atccctttgg tattgatttc acagtcagct gctcaacgga
4981 atggcctctc cacaccaggg atccttagca cccaaccggt ctgcccttaa ttttacccag
5041 gaaggactca cattggggcg aatgaaccaa gtttcgccat gctggatgat gaaatggatt
5101 cccatcccaa agtctgagat ggattgcata tacagtgtgc agtcccagag cctcctaaaa
5161 ttctagccat ttgtcacaca accacagcaa gaaacgtgtt ctatatctag agtgtgccca
5221 tctgtgttta gtacacatgc atgcatacac acccatacaa acatctgtgt gagggcagtt
5281 ctggagatga gcagagagag accggaataa actcaatctt ttctttccca agctcctagc
5341 caacactatc cttgggagaa aggaatttgc agaaactgct aagaccaagt gtggagatgt
5401 caagctagtt cacactctga ggctcagaat atgtaggaca tgcacaattg tgcagtcctt
5461 tgggattgga agtgaaacag tctgtgatcc cctaccttct agggaactag gacctaggaa
5521 gaggtaaaga ttatcaggta tgcaaagcgc cccaattctt ctgctgccat gggggatttt
5581 accccaactc cagggttcga ggccaatctg agaatggctt aggattgcaa tgtcaaggta
5641 ttatatcagc cccttgcttg aggcttgagg tcataatatc cctctaggac ttacctgttc
5701 ccccagatct tgccttggga ccacatttgc tgctactttt cctgctgctc tatcctatac
5761 attgaataat ccaagatggt agaactaggt taggaaaaat tccacacaac caaacagtct
5821 gccttaaaag tgacccacat ttttccatag ctcctcactt tttagccctt ctgcaagaga
5881 aaaaccctca tgggtccaca tggtgagaag ttaagtttcc tgtaagtggg cctctcaccc
5941 tggaaaggag ttgagggaca tcagatgctg gaaccctcac tgaaagtcca gaatgtctaa
6001 gccagtgtta gattttgtaa acaagtggaa cagtgttaaa tttctatgat gttggagcca
6061 tccagagact actggaattg tcgagacttt tggattatta tccttatcct tatcctaatc
6121 ttcctagccc ttcaggctag agtaggcttc gatcctgaga accttgctgt tgctctgagg
6181 agatataatt ctgggagaaa gaatctttta taagaacagt acagattgtt ctcaagaggg
6241 ccatcagaag gaagccaaag agttcacagc ctcagcacca acaactcaac atggtcatca
6301 tgttttctat atggtttttc cagctagcag tactcccttc catacctgtg actgggcagt
6361 gcttttctct ctcccatgtc tagcctccaa aagttaagtg aaaattagtc aactgcacgt
6421 ggaagccccc accactttgg ggatctcttt atttcttttc agccagggac ctgtccactc
6481 cctttgaatt aatatgggaa gaaattaata caggatgaac tggagagaag ggttgagtgt
6541 ggcatacttt ctgaaacctg gagctgggaa ttgcggagaa gggaaggtct agactagtta
6601 catcacatag ggattactgt aaatcaagtc atctcaagtc tagtgaagac agccaacaga
6661 aacaaaacct agcataggga tagaaaatac catgcacgtg tgcagcccca cctaattcct
6721 gcatccaagg caggtgttgt taatctatca tagcaccaaa aaaaaaaaaa aaa
//