LOCUS BC075849 2585 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens signal-regulatory protein alpha, mRNA (cDNA clone
MGC:88840 IMAGE:4589732), complete cds.
ACCESSION BC075849
VERSION BC075849.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2585)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2585)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (06-JUL-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 58 Row: c Column: 19
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 18426910.
FEATURES Location/Qualifiers
source 1..2585
/db_xref="H-InvDB:HIT000265661"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:88840 IMAGE:4589732"
/tissue_type="Kidney, renal cell adenocarcinoma"
/clone_lib="NIH_MGC_14"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2585
/gene="SIRPA"
/gene_synonym="BIT"
/gene_synonym="CD172A"
/gene_synonym="MFR"
/gene_synonym="MYD-1"
/gene_synonym="P84"
/gene_synonym="SHPS-1"
/gene_synonym="SHPS1"
/gene_synonym="SIRP"
/gene_synonym="SIRP-ALPHA-1"
/gene_synonym="SIRPalpha"
/gene_synonym="SIRPalpha2"
/db_xref="GeneID:140885"
/db_xref="HGNC:HGNC:9662"
/db_xref="MIM:602461"
CDS 210..1721
/gene="SIRPA"
/gene_synonym="BIT"
/gene_synonym="CD172A"
/gene_synonym="MFR"
/gene_synonym="MYD-1"
/gene_synonym="P84"
/gene_synonym="SHPS-1"
/gene_synonym="SHPS1"
/gene_synonym="SIRP"
/gene_synonym="SIRP-ALPHA-1"
/gene_synonym="SIRPalpha"
/gene_synonym="SIRPalpha2"
/codon_start=1
/product="signal-regulatory protein alpha"
/protein_id="AAH75849.1"
/db_xref="GeneID:140885"
/db_xref="HGNC:HGNC:9662"
/db_xref="MIM:602461"
/translation="MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVS
VAAGESAILHCTVTSLIPVGPIQWFRGAGPARELIYNQKEGHFPRVTTVSESTKRENM
DFSISISNITPADAGTYYCVKFRKGSPDTEFKSGAGTELSVRAKPSAPVVSGPAARAT
PQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTR
EDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRK
FYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEH
DGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALYL
VRIRQKKAQGSTSSTRLHEPEKNAREITQDTNDITYADLNLPKGKKPAPQAAEPNNHT
EYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK"
BASE COUNT 603 a 831 c 696 g 455 t
ORIGIN
1 cggggagcag ccgcgcggcc ggagtccgga ggcgagggga ggtcggccgc aacttccccg
61 gtccacctta agaggacgat gtagccagct cgcagcgctg accttagaaa aacaagtttg
121 cgcaaagtgg agcggggacc cggcctctgg gcagccccgg cggcgcttcc agtgccttcc
181 agccctcgcg ggcggcgcag ccgcggccca tggagcccgc cggcccggcc cccggccgcc
241 tcgggccgct gctctgcctg ctgctcgccg cgtcctgcgc ctggtcagga gtggcgggtg
301 aggaggagct gcaggtgatt cagcctgaca agtccgtatc agttgcagct ggagagtcgg
361 ccattctgca ctgcactgtg acctccctga tccctgtggg gcccatccag tggttcagag
421 gagctggacc agcccgggaa ttaatctaca atcaaaaaga aggccacttc ccccgggtaa
481 caactgtttc agagtccaca aagagagaaa acatggactt ttccatcagc atcagtaaca
541 tcaccccagc agatgccggc acctactact gtgtgaagtt ccggaaaggg agccctgaca
601 cggagtttaa gtctggagca ggcactgagc tgtctgtgcg tgccaaaccc tctgcccccg
661 tggtatcggg ccctgcggcg agggccacac ctcagcacac agtgagcttc acctgcgagt
721 cccacggctt ctcacccaga gacatcaccc tgaaatggtt caaaaatggg aatgagctct
781 cagacttcca gaccaacgtg gaccccgtag gagagagcgt gtcctacagc atccacagca
841 cagccaaggt ggtgctgacc cgcgaggacg ttcactctca agtcatctgc gaggtggccc
901 acgtcacctt gcagggggac cctcttcgtg ggactgccaa cttgtctgag accatccgag
961 ttccacccac cttggaggtt actcaacagc ccgtgagggc agagaaccag gtgaatgtca
1021 cctgccaggt gaggaagttc tacccccaga gactacagct gacctggttg gagaatggaa
1081 acgtgtcccg gacagaaacg gcctcaaccg ttacagagaa caaggatggt acctacaact
1141 ggatgagctg gctcctggtg aatgtatctg cccacaggga tgatgtgaag ctcacctgcc
1201 aggtggagca tgacgggcag ccagcggtca gcaaaagcca tgacctgaag gtctcagccc
1261 acccgaagga gcagggctca aataccgccg ctgagaacac tggatctaat gaacggaaca
1321 tctatattgt ggtgggtgtg gtgtgcacct tgctggtggc cctactgatg gcggccctct
1381 acctcgtccg aatcagacag aagaaagccc agggctccac ttcttctaca aggttgcatg
1441 agcccgagaa gaatgccaga gaaataacac aggacacaaa tgatatcaca tatgcagacc
1501 tgaacctgcc caaggggaag aagcctgctc cccaggctgc ggagcccaac aaccacacgg
1561 agtatgccag cattcagacc agcccgcagc ccgcgtcgga ggacaccctc acctatgctg
1621 acctggacat ggtccacctc aaccggaccc ccaagcagcc ggcccccaag cctgagccgt
1681 ccttctcaga gtacgccagc gtccaggtcc cgaggaagtg aatgggaccg tggtttgctc
1741 tagcacccat ctctacgcgc tttcttgtcc cacagggagc cgccgtgatg agcacagcca
1801 acccagttcc cggagggctg gggcggtgca ggctctggga cccaggggcc agggtggctc
1861 ttctctcccc acccctcctt ggctctccag cacttcctgg gcagccacgg ccccctcccc
1921 ccacattgcc acatacctgg aggctgacgt tgccaaacca gccagggaac caacctggga
1981 agtggccaga acttcctggg gtccaagaac tcttgtgcct ccgtccatca ccatgtgggt
2041 tttgaagacc ctcgactgcc tccccgatgc tccgaagcct gatcttccag ggtggggagg
2101 agaaaatccc acctcccctg acctccacca cctccaccac caccaccacc accaccacca
2161 ccactaccac caccacccaa ctggggctag agtggggaag atttcccctt tagatcaaac
2221 tgccccttcc atggaaaagc tggaaaaaaa ctctggaacc catatccagg cttggtgagg
2281 ttgctgccaa cagtcctggc ctcccccatc cctaggctaa agagccatga gtcctggagg
2341 aggagaggac ccctcccaaa ggactggaga caaaaccctc tgcttccttg ggtccctcca
2401 agactccctg gggcccaact gtgttgctcc acccggaccc atctctccct tctagacctg
2461 agcttgcccc tccagctagc actaagcaac atctcgctgt ggacgcctgt aaattactga
2521 gaaatgtgaa acgtgcaatc ttgaaactga ggtgttagaa aacttgaaaa aaaaaaaaaa
2581 aaaaa
//