LOCUS BC073979 3968 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens potassium voltage-gated channel, subfamily H
(eag-related), member 5, mRNA (cDNA clone MGC:88066 IMAGE:6199697),
complete cds.
ACCESSION BC073979
VERSION BC073979.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3968)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3968)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (23-JUN-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. James R. Lupski
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 174 Row: n Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 27886645.
FEATURES Location/Qualifiers
source 1..3968
/db_xref="H-InvDB:HIT000265200"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:88066 IMAGE:6199697"
/tissue_type="Peripheral Nervous System, sympathetic
trunk"
/clone_lib="Lupski_sympathetic_trunk"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3968
/gene="KCNH5"
/gene_synonym="EAG2"
/gene_synonym="H-EAG2"
/gene_synonym="Kv10.2"
/db_xref="GeneID:27133"
/db_xref="HGNC:HGNC:6254"
/db_xref="MIM:605716"
CDS 53..3019
/gene="KCNH5"
/gene_synonym="EAG2"
/gene_synonym="H-EAG2"
/gene_synonym="Kv10.2"
/codon_start=1
/product="potassium voltage-gated channel, subfamily H
(eag-related), member 5"
/protein_id="AAH73979.1"
/db_xref="GeneID:27133"
/db_xref="HGNC:HGNC:6254"
/db_xref="MIM:605716"
/translation="MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSN
DGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNR
TPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSR
SVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWD
WVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGE
VISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV
ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL
ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV
AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY
IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEF
QTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLA
HACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDV
KKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVESRS
LQNGTSITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGADQKCLKVN
SPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKN
PLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVK
HELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFS
VSRPESPESDKDEIHF"
BASE COUNT 1176 a 838 c 868 g 1086 t
ORIGIN
1 gcatcccccc ctcccccgcc gcggatcctg gccgctgctc tccagaccca ggatgccggg
61 gggcaagaga gggctggtgg caccgcagaa cacatttttg gagaacatcg tcaggcgctc
121 cagtgaatca agtttcttac tgggaaatgc ccagattgtg gattggcctg tagtttatag
181 taatgacggt ttttgtaaac tctctggata tcatcgagct gacgtcatgc agaaaagcag
241 cacttgcagt tttatgtatg gggaattgac tgacaagaag accattgaga aagtcaggca
301 aacttttgac aactacgaat caaactgctt tgaagttctt ctgtacaaga aaaacagaac
361 ccctgtttgg ttttatatgc aaattgcacc aataagaaat gaacatgaaa aggtggtctt
421 gttcctgtgt actttcaagg atattacgtt gttcaaacag ccaatagagg atgattcaac
481 aaaaggttgg acgaaatttg cccgattgac acgggctttg acaaatagcc gaagtgtttt
541 gcagcagctc acgccaatga ataaaacaga ggtggtccat aaacattcaa gactagctga
601 agttcttcag ctgggatcag atatccttcc tcagtataaa caagaagcgc caaagacgcc
661 accacacatt attttacatt attgtgcttt taaaactact tgggattggg tgattttaat
721 tcttaccttc tacaccgcca ttatggttcc ttataatgtt tccttcaaaa caaagcagaa
781 caacatagcc tggctggtac tggatagtgt ggtggacgtt atttttctgg ttgacatcgt
841 tttaaatttt cacacgactt tcgtggggcc cggtggagag gtcatttctg accctaagct
901 cataaggatg aactatctga aaacttggtt tgtgatcgat ctgctgtctt gtttacctta
961 tgacatcatc aatgcctttg aaaatgtgga tgagggaatc agcagtctct tcagttcttt
1021 aaaagtggtg cgtctcttac gactgggccg tgtggctagg aaactggacc attacctaga
1081 atatggagca gcagtcctcg tgctcctggt gtgtgtgttt ggactggtgg cccactggct
1141 ggcctgcata tggtatagca tcggagacta cgaggtcatt gatgaagtca ctaacaccat
1201 ccaaatagac agttggctct accagctggc tttgagcatt gggactccat atcgctacaa
1261 taccagtgct gggatatggg aaggaggacc cagcaaggat tcattgtacg tgtcctctct
1321 ctactttacc atgacaagcc ttacaaccat aggatttgga aacatagctc ctaccacaga
1381 tgtggagaag atgttttcgg tggctatgat gatggttggc tctcttcttt atgcaactat
1441 ttttggaaat gttacaacaa ttttccagca aatgtatgcc aacaccaacc gataccatga
1501 gatgctgaat aatgtacggg acttcctaaa actctatcag gtcccaaaag gccttagtga
1561 gcgagtcatg gattatattg tctcaacatg gtccatgtca aaaggcattg atacagaaaa
1621 ggtcctctcc atctgtccca aggacatgag agctgatatc tgtgttcatc taaaccggaa
1681 ggtttttaat gaacatcctg cttttcgatt ggccagcgat gggtgtctgc gcgccttggc
1741 ggtagagttc caaaccattc actgtgctcc cggggacctc atttaccatg ctggagaaag
1801 tgtggatgcc ctctgctttg tggtgtcagg atccttggaa gtcatccagg atgatgaggt
1861 ggtggctatt ttagggaagg gtgatgtatt tggagacatc ttctggaagg aaaccaccct
1921 tgcccatgca tgtgcgaacg tccgggcact gacgtactgt gacctacaca tcatcaagcg
1981 ggaagccttg ctcaaagtcc tggactttta tacagctttt gcaaactcct tctcaaggaa
2041 tctcactctt acttgcaatc tgaggaaacg gatcatcttt cgtaagatca gtgatgtgaa
2101 gaaagaggag gaggagcgcc tccggcagaa gaatgaggtg accctcagca ttcccgtgga
2161 ccacccagtc agaaagctct tccagaagtt caagcagcag aaggagctgc ggaatcaggg
2221 ctcaacacag ggtgaccctg agaggaacca actccaggta gagagccgct ccttacagaa
2281 tggaacctcc atcaccggaa ccagcgtggt gactgtgtca cagattactc ccattcagac
2341 gtctctggcc tatgtgaaaa ccagtgaatc ccttaagcag aacaaccgtg atgccatgga
2401 actcaagccc aacggcggtg ctgaccaaaa atgtctcaaa gtcaacagcc caataagaat
2461 gaagaatgga aatggaaaag ggtggctgcg actcaagaat aatatgggag cccatgagga
2521 gaaaaaggaa gactggaata atgtcactaa agctgagtca atggggctat tgtctgagga
2581 ccccaagagc agtgattcag agaacagtgt gaccaaaaac ccactaagga aaacagattc
2641 ttgtgacagt ggaattacaa aaagtgacct tcgtttggat aaggctgggg aggcccgaag
2701 tccgctagag cacagtccca tccaggctga tgccaagcac cccttttatc ccatccccga
2761 gcaggcctta cagaccacac tgcaggaagt caaacacgaa ctcaaagagg acatccagct
2821 gctcagctgc agaatgactg ccctagaaaa gcaggtggca gaaattttaa aaatactgtc
2881 ggaaaaaagc gtaccccagg cctcatctcc caaatcccaa atgccactcc aagtaccccc
2941 ccagatacca tgtcaggata tttttagtgt ctcaaggcct gaatcacctg aatctgacaa
3001 agatgaaatc cacttttaat atatatacat atatatttgt taatatatta aaacagtata
3061 tacatatgtg tgtatataca gtatatacat atatatattt tcacttgctt tcaagatgat
3121 gaccacacat ggattttgat atgtaaatat tgcatgtcca gctggattct ggcctgccaa
3181 agaagatgat gattaaaaac atagatattg cttgtatatt atgcagttga ctgcatgcac
3241 actttacatt tatttataat ctctattcta taataaaaga gtatgatttt tgttacccaa
3301 ggcaatgtaa tatttgaaga atcagggtcc aacctgccaa tgttgccatg acaaatttga
3361 tctcaggctg agtatgtata tcgagctatc attttctcac tgttctgtta agttaaaagt
3421 atagattaat gccaaggaag agttcagtct tttaaactat tagtaccatg ttatgatctc
3481 tttccatagg atatttttct gtaacttagt gttaggttct tttcccctac aggcagtgtt
3541 tgctccattt aaatgactgt ttagttgcct aagtcagata agagtgtggg atattgaaaa
3601 cttattgcta tgggttttgt gcatgaatta catttttgat caactatacc tctcgttttt
3661 taacattata cttagatagt aatcattagc tcttatgtaa ggaaatccct actccctcct
3721 tcttggagaa cagctgccat cttgtaagct gacattatca acatcataaa tactaaacta
3781 ttaatataga gtatgttatt atagaaacac tgcaccacag ggtataaggg ccttttgaca
3841 attcatgtaa gagatgctga atttccaaag ctgataaatg ctctaaattt gtatttccaa
3901 aacatgttca agagtgacat tgaaaggctt gttagcaaag aaacatacaa aaaaaaaaaa
3961 aaaaaaaa
//