LOCUS BC066877 1362 bp mRNA linear HUM 30-MAR-2004
DEFINITION Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6,
mRNA (cDNA clone IMAGE:7002156), partial cds.
ACCESSION BC066877
VERSION BC066877.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1362)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1362)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (01-MAR-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Narayan Bhat
cDNA Library Preparation: Bhat Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 172 Row: h Column: 4
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 14110384.
FEATURES Location/Qualifiers
source 1..1362
/db_xref="H-InvDB:HIT000262298"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:7002156"
/tissue_type="PCR rescued clones"
/clone_lib="NIH_MGC_195"
/lab_host="DH10B"
/note="Vector: pDNR-Dual"
gene <1..1362
/gene="CYP2D6"
/gene_synonym="CPD6"
/gene_synonym="CYP2D"
/gene_synonym="CYP2D@"
/gene_synonym="CYP2DL1"
/gene_synonym="P450-DB1"
/gene_synonym="P450C2D"
/db_xref="GeneID:1565"
/db_xref="MIM:124030"
CDS <1..1342
/gene="CYP2D6"
/gene_synonym="CPD6"
/gene_synonym="CYP2D"
/gene_synonym="CYP2D@"
/gene_synonym="CYP2DL1"
/gene_synonym="P450-DB1"
/gene_synonym="P450C2D"
/codon_start=2
/product="CYP2D6 protein"
/protein_id="AAH66877.1"
/db_xref="GeneID:1565"
/db_xref="MIM:124030"
/translation="MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLG
NLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRP
PVPITQILGFGPRSQGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE
GLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPR
DLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDV
QRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQ
GFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRAC
LGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR"
misc_feature 173..1330
/gene="CYP2D6"
/gene_synonym="CPD6"
/gene_synonym="CYP2D"
/gene_synonym="CYP2D@"
/gene_synonym="CYP2DL1"
/gene_synonym="P450-DB1"
/gene_synonym="P450C2D"
/note="p450; Region: Cytochrome P450. Cytochrome P450s are
involved in the oxidative degradation of various
compounds. Particularly well known for their role in the
degradation of environmental toxins and mutagens.
Structure is mostly alpha, and binds a heme cofactor"
/db_xref="CDD:pfam00067"
BASE COUNT 234 a 463 c 398 g 267 t
ORIGIN
1 tatggggcta gaagcactgg tgcccctggc cgtgatagtg gccatcttcc tgctcctggt
61 ggacctgatg caccggcgcc aacgctgggc tgcacgctac ccaccaggcc ccctgccact
121 gcccgggctg ggcaacctgc tgcatgtgga cttccagaac acaccatact gcttcgacca
181 gttgcggcgc cgcttcgggg acgtgttcag cctgcagctg gcctggacgc cggtggtcgt
241 gctcaatggg ctggcggccg tgcgcgaggc gctggtgacc cacggcgagg acaccgccga
301 ccgcccgcct gtgcccatca cccagatcct gggtttcggg ccgcgttccc aaggacgccc
361 ctttcgcccc aacggtctct tggacaaagc cgtgagcaac gtgatcgcct ccctcacctg
421 cgggcgccgc ttcgagtacg acgaccctcg cttcctcagg ctgctggacc tagctcagga
481 gggactgaag gaggagtcgg gctttctgcg cgaggtgctg aatgctgtcc ccgtcctcct
541 gcatatccca gcgctggctg gcaaggtcct acgcttccaa aaggctttcc tgacccagct
601 ggatgagctg ctaactgagc acaggatgac ctgggaccca gcccagcccc cccgagacct
661 gactgaggcc ttcctggcag agatggagaa ggccaagggg aaccctgaga gcagcttcaa
721 tgatgagaac ctgtgcatag tggtggctga cctgttctct gccgggatgg tgaccacctc
781 gaccacgctg gcctggggcc tcctgctcat gatcctacat ccggatgtgc agcgccgtgt
841 ccaacaggag atcgacgacg tgatagggca ggtgcggcga ccagagatgg gtgaccaggc
901 tcacatgccc tacaccactg ccgtgattca tgaggtgcag cgctttgggg acatcgtccc
961 cctgggtgtg acccatatga catcccgtga catcgaagta cagggcttcc gcatccctaa
1021 gggaacgaca ctcatcacca acctgtcatc ggtgctgaag gatgaggccg tctgggagaa
1081 gcccttccgc ttccaccccg aacacttcct ggatgcccag ggccactttg tgaagccgga
1141 ggccttcctg cctttctcag caggccgccg tgcatgcctc ggggagcccc tggcccgcat
1201 ggagctcttc ctcttcttca cctccctgct gcagcacttc agcttctcgg tgcccactgg
1261 acagccccgg cccagccacc atggtgtctt tgctttcctg gtgaccccat ccccctatga
1321 gctttgtgct gtgccccgct agaaaggggt acctagtccc ca
//