LOCUS BC066647 4766 bp mRNA linear HUM 03-NOV-2008
DEFINITION Homo sapiens KIAA0586, mRNA (cDNA clone MGC:70738 IMAGE:6166031),
complete cds.
ACCESSION BC066647
VERSION BC066647.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4766)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4766)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-MAR-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 140 Row: o Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 41281468.
FEATURES Location/Qualifiers
source 1..4766
/db_xref="H-InvDB:HIT000262280"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:70738 IMAGE:6166031"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_72"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..4766
/gene="KIAA0586"
/gene_synonym="Talpid3"
/db_xref="GeneID:9786"
/db_xref="HGNC:HGNC:19960"
/db_xref="MIM:610178"
CDS 229..4647
/gene="KIAA0586"
/gene_synonym="Talpid3"
/codon_start=1
/product="KIAA0586"
/protein_id="AAH66647.2"
/db_xref="GeneID:9786"
/db_xref="HGNC:HGNC:19960"
/db_xref="MIM:610178"
/translation="MKGSEVSLEKKKKIKMPVKRLREVVSQNHGDHLVLLKDELPCVP
PALSANKRLPVGTGTSLNGTSRGSSDLTSARNCYQPLLENPMVSESDFSKDVAVQVLP
LDKIEENNKQKANDIFISQYTMGQKDALRTVLKQKAQSMPVFKEVKVHLLEDAGIEKD
AVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETD
KHLQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAA
LKTSSFQPVSMPSSRAVEKYSVKPEHPNLGSCNPSLYNTFASKQAPLKEVEDTSFDKQ
KSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSL
TRKSESSNTTSLTRSKIGWTPEKTNRFPSCEELETTKVTMQKSDDVLHDLGQKEKETN
SMVQPKESLSMLKLPDLPQNSVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAI
IRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQGLLKATTVIQDEDY
MLQVYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFY
ATKPKKMDSKMKHSVPVLPHGDQQYLFSPSREMPTFSGTLEGHLIPMAILLGQTQSNS
DTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVL
PSVDIDSISNSSADVLSPLSSPKEASPPPVQTWIKTPEIMKVDEEEVKFPGTNFDEII
DVIQEEEKCDEIPDSEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERK
ETLENSLIQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLTSDIVEGTSSGAL
QLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNETYLP
ARVCTPLATPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMAFPVKEICAEKGDDMP
AIMLVNTPTVTPTTTPPPAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENP
NSPQEELHPRAIVMSVAKDEEPESMDFPAQPPPPEPVPFMPFPAGTKAPSPSQMPGSD
SSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTL
HDAVEMEDDPPSEGQVIRMSHKKFHADAILSFAKQNQESAVSQQAVYHSEDLENSVGE
LSEGQRPQLTAAAENILMGHSLYMQPPVTNTQSLDQQCDPKPLSRQFDTVSGSIYEDS
CASHGPMSLGELELEPNSKLVLPTTLLTAQENDVNLPVAAEDFSQYQLKQNQDVKQVE
HKPSQSYLRVRNKSDIAPSQQQVSPGDMDRTQIELNPYLTCVFSGGKAVPLSASQMPP
AKMSVMLPSVNLEDCSQSLSLSTMQEDMESSGADTF"
BASE COUNT 1556 a 957 c 988 g 1265 t
ORIGIN
1 attttggcgt ggtgtattaa tagactgagt gggattaatg ggtaaatatg actttatagt
61 cagctctaat cctggattca atatcagaat ttagattttc agctttgtgg atgttcgaca
121 ttttaaaaac agttattgca aagaggtgaa aattttgttc tgaagtctta aggaaacaga
181 gaaagttttt ccgtccttaa gtgtgggact tgttttgtga ccaacaatat gaaaggctct
241 gaggtcagct tggagaagaa aaaaaagatt aagatgccag tgaagagact tcgtgaggta
301 gtttctcaaa atcatggaga tcatttggtt ttgctgaaag atgagttgcc ctgtgttcct
361 ccggcattgt ctgcaaataa acgtcttcct gttggaacgg ggactagttt gaatggaaca
421 tcacgtggtt catcagactt aacttctgct agaaattgtt accagcctct attagaaaat
481 cccatggtgt cagaaagtga tttttctaaa gacgttgcag tgcaagtgtt gcctttggat
541 aaaatagaag agaacaacaa gcaaaaagca aatgacatct tcatttctca gtatacaatg
601 ggacagaaag atgctctaag aacagtttta aagcaaaaag ctcaaagcat gcctgttttt
661 aaggaagtaa aggtacatct gttagaagat gcaggcatag agaaggatgc tgttactcag
721 gagactagaa tttcacccag tggaattgat tcagctacaa ccgtggctgc agcaactgct
781 gctgccattg caaccgcagc tccgttgata aaggtgcaga gtgatttgga agcaaaagtc
841 aattctgtta cagaattact tagtaaatta caggagactg ataaacacct gcaacgtgtt
901 acagagcagc aaacaagcat tcagaggaaa caagagaaat tacattgtca tgatcacgaa
961 aagcaaatga atgtgtttat ggagcagcac ataaggcatc ttgaaaagtt acaacaacaa
1021 caaatagata ttcagactca ttttattagt gctgcactca agactagtag ttttcagcct
1081 gttagtatgc cctcctccag agcagtggaa aagtattccg taaaaccaga acaccctaat
1141 cttggtagct gtaatccatc tttatataac acatttgctt ccaaacaagc acctttaaaa
1201 gaagttgaag atacgagttt tgataaacag aaatctcctt tggagacacc agcacctcgc
1261 agatttgctc ctgtacctgt ttcaagggat gatgaactat caaagaggga aaatcttttg
1321 gaagaaaaag aaaatatgga agtgtcatgt cacagaggaa atgtaagact attggaacaa
1381 attttgaata ataatgattc tttgacaaga aaaagtgaat catcaaacac cacctcacta
1441 actaggtcaa aaataggatg gactcctgag aaaacaaaca gatttccttc ctgtgaagag
1501 ctagaaacaa ctaaagtgac tatgcagaag tctgatgatg ttcttcatga ccttggccaa
1561 aaagagaaag aaacaaatag catggtccag ccaaaagaat ctctgagtat gttgaagctt
1621 ccagatcttc cacagaattc tgttaagctt caaacaacca atacaacaag atctgtattg
1681 aaagatgctg agaagatttt gagaggagta caaaacaata aaaaagtact tgaagaaaac
1741 ctggaagcta ttattcgtgc aaaagatgga gctgccatgt attcgcttat caatgcttta
1801 tctaccaaca gagagatgtc agagaaaatt aggatcagaa agacagtgga tgaatggatt
1861 aaaactattt ctgcagaaat tcaggggctt ttgaaagcaa ccacagtaat acaagatgaa
1921 gattatatgt tacaagtcta tggaaagcca gtttatcagg gccatcgaag cactcttaaa
1981 aaaggaccat atctcagatt taattctcca tctcctaagt ccagaccaca gagaccaaaa
2041 gtaatagaac gagttaaagg cactaaggta aagtcaataa gaacacagac tgacttctat
2101 gcaacaaaac ctaagaagat ggattctaaa atgaaacatt ctgttcctgt gttacctcat
2161 ggcgatcagc aatatttgtt cagcccaagt agagaaatgc ctactttttc aggtacattg
2221 gaaggtcatc tgattcctat ggcaattctt ttaggacaaa cccaaagtaa tagtgatacc
2281 atgccacctg ctggagtgat tgtcagcaag ccacaccctg taactgtgac tacttctatt
2341 cctccatcat ctcgaaaagt agaaactgga gtaaagaaac ctaacatagc cattgtagaa
2401 atgaagtcag aaaaaaagga tcctcctcag cttactgtgc aggtattacc cagtgtagat
2461 attgacagca tttcaaatag tagtgctgat gtcctttcac ctctgtctag ccccaaagaa
2521 gcatctcctc ctcctgtgca aacttggata aagactccag aaattatgaa ggtagatgaa
2581 gaagaggtga agtttccagg aactaacttt gatgaaataa tcgatgtcat acaggaagaa
2641 gaaaaatgtg atgaaattcc agactctgaa ccaattctgg agtttaacag aagtgttaaa
2701 gctgattcta caaaatataa tggtcctcca tttccgccag ttgcttctac ttttcagccc
2761 actgctgata ttctggataa agtaattgag agaaaagaaa cactggaaaa tagcttaatt
2821 caatgggtag agcaagaaat aatgtcaaga attatctctg ggctctttcc agtccagcaa
2881 cagattgcac ctagtatcag tgtttcagtc agtgagacaa gtgaaccact gacttctgac
2941 attgtggaag gaacaagcag tggcgccctc cagctttttg ttgatgctgg tgttcctgtg
3001 aactcaaatg tgattaaaca ttttgttaac gaagctcttg ctgagaccat tgctgtcatg
3061 ctgggtgaca gagaagcaaa gaagcaaggt cctgttgcta caggtgtttc tggggatgct
3121 tcaacaaatg aaacatattt gccggcaaga gtgtgcaccc cactggctac cccacagcct
3181 acgcctcctt gctcaccttc atcacctgct aaggagtgtg ttttggtaaa gactccagat
3241 tcttctccct gtgattcgga tcatgatatg gcttttcctg tgaaagaaat atgtgctgaa
3301 aaaggagatg atatgcctgc catcatgctt gttaatactc caacagttac ccctactact
3361 acacctcctc cagcggcggc agtttttacc ccaactttgt cagatatttc cattgataaa
3421 ttgaaggtat caagcccaga gcttcccaag ccatggggtg atggagacct gccactggaa
3481 gaagagaacc ctaactcacc tcaagaagaa cttcatccaa gagctattgt aatgtctgtg
3541 gctaaggatg aagaaccaga gagtatggat ttccctgctc agcctccacc tccagagcca
3601 gttcccttta tgccatttcc tgccggcacc aaggcccctt ccccctcaca gatgccaggt
3661 tctgattcat caacactgga gagcacattg agtgttactg tcactgaaac tgaaacttta
3721 gataaaccca tctctgaagg agagatttta tttagctgtg gtcaaaaatt ggcccccaag
3781 attttagaag atataggact gtacctgaca aaccttaatg atagcttatc cagcactctg
3841 catgatgccg ttgaaatgga ggatgatcct cctagtgaag ggcaagtgat taggatgtcc
3901 cataaaaaat ttcatgcaga tgcaattctt tcttttgcta aacaaaacca ggagtcagca
3961 gtttcccagc aagcagtcta tcattcagag gacttggaaa acagtgtggg tgaacttagt
4021 gaaggacaaa gaccccagct aacagcggca gcagagaaca tcttaatggg acattctctc
4081 tatatgcagc cacctgtcac taatacacag tctttggatc aacaatgtga tcctaaacca
4141 ttatctcggc aatttgacac agtttcaggt agtatttatg aagattcatg tgctagtcat
4201 ggtccaatga gtttgggaga attggagttg gagccaaatt ctaagctggt tcttcccaca
4261 acacttctga cagcacaaga aaatgatgtt aatttaccag tagccgctga agatttttcc
4321 cagtaccaac taaagcaaaa tcaggatgtt aagcaagttg aacacaaacc atcacaaagt
4381 tacctacgtg ttagaaataa atctgatatt gcaccttcac agcaacaagt ttcaccaggt
4441 gatatggatc ggacacaaat tgagcttaat ccgtacctca catgtgtatt ttcaggtggg
4501 aaagcagtgc cactctccgc ttcacagatg ccccctgcca agatgtcagt gatgctgccg
4561 tcagtgaacc tcgaggactg ctctcagtct ctgagtctca gcacaatgca ggaggacatg
4621 gagtcttcgg gggcagatac cttctgaacg ggaagagaca gccagcacag tgtttatgcc
4681 actggtttta aagtcatttt accttggctt aaaaccctct ctcagactgt ttggtttttg
4741 agcatattct gaaaaaaaaa aaaaaa
//