LOCUS BC065492 3893 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens beta-site APP-cleaving enzyme 1, mRNA (cDNA clone
MGC:71162 IMAGE:6538154), complete cds.
ACCESSION BC065492
VERSION BC065492.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3893)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3893)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (26-JAN-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 50 Row: n Column: 6.
FEATURES Location/Qualifiers
source 1..3893
/db_xref="H-InvDB:HIT000261901"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:71162 IMAGE:6538154"
/tissue_type="Lung, epidermoid carcinoma"
/clone_lib="NIH_MGC_101"
/lab_host="DH10B"
/note="Vector: pOTB7"
gene 1..3893
/gene="BACE1"
/gene_synonym="ASP2"
/gene_synonym="HSPC104"
/gene_synonym="KIAA1149"
/db_xref="GeneID:23621"
/db_xref="HGNC:HGNC:933"
/db_xref="MIM:604252"
CDS 462..1967
/gene="BACE1"
/gene_synonym="ASP2"
/gene_synonym="HSPC104"
/gene_synonym="KIAA1149"
/codon_start=1
/product="beta-site APP-cleaving enzyme 1"
/protein_id="AAH65492.1"
/db_xref="GeneID:23621"
/db_xref="HGNC:HGNC:933"
/db_xref="MIM:604252"
/translation="MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLP
RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG
AAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI
AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGA
GFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM
DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG
TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT
VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQT
DESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK"
BASE COUNT 897 a 1116 c 1005 g 875 t
ORIGIN
1 acaagtcttt ccgcctcccc agcccgcccg ggagctgcga gccgcgagct ggattatggt
61 ggcctgagca gccaacgcag ccgcaggagc ccggagccct tgcccctgcc cgcgccgccg
121 cccgccgggg ggaccaggga agccgccacc ggcccgccat gcccgcccct cccagccccg
181 ccgggagccc gcgcccgctg cccaggctgg ccgccgccgt gccgatgtag cgggctccgg
241 atcccagcct ctcccctgct cccgtgctct gcggatctcc cctgaccgct ctccacagcc
301 cggacccggg ggctggccca gggccctgca ggccctggcg tcctgatgcc cccaagctcc
361 ctctcctgag aagccaccag caccacccag acttgggggc aggcgccagg gacggacgtg
421 ggccagtgcg agcccagagg gcccgaaggc cggggcccac catggcccaa gccctgccct
481 ggctcctgct gtggatgggc gcgggagtgc tgcctgccca cggcacccag cacggcatcc
541 ggctgcccct gcgcagcggc ctggggggcg cccccctggg gctgcggctg ccccgggaga
601 ccgacgaaga gcccgaggag cccggccgga ggggcagctt tgtggagatg gtggacaacc
661 tgaggggcaa gtcggggcag ggctactacg tggagatgac cgtgggcagc cccccgcaga
721 cgctcaacat cctggtggat acaggcagca gtaactttgc agtgggtgct gccccccacc
781 ccttcctgca tcgctactac cagaggcagc tgtccagcac ataccgggac ctccggaagg
841 gtgtgtatgt gccctacacc cagggcaagt gggaagggga gctgggcacc gacctggtaa
901 gcatccccca tggccccaac gtcactgtgc gtgccaacat tgctgccatc actgaatcag
961 acaagttctt catcaacggc tccaactggg aaggcatcct ggggctggcc tatgctgaga
1021 ttgccaggcc tgacgactcc ctggagcctt tctttgactc tctggtaaag cagacccacg
1081 ttcccaacct cttctccctg cagctttgtg gtgctggctt ccccctcaac cagtctgaag
1141 tgctggcctc tgtcggaggg agcatgatca ttggaggtat cgaccactcg ctgtacacag
1201 gcagtctctg gtatacaccc atccggcggg agtggtatta tgaggtgatc attgtgcggg
1261 tggagatcaa tggacaggat ctgaaaatgg actgcaagga gtacaactat gacaagagca
1321 ttgtggacag tggcaccacc aaccttcgtt tgcccaagaa agtgtttgaa gctgcagtca
1381 aatccatcaa ggcagcctcc tccacggaga agttccctga tggtttctgg ctaggagagc
1441 agctggtgtg ctggcaagca ggcaccaccc cttggaacat tttcccagtc atctcactct
1501 acctaatggg tgaggttacc aaccagtcct tccgcatcac catccttccg cagcaatacc
1561 tgcggccagt ggaagatgtg gccacgtccc aagacgactg ttacaagttt gccatctcac
1621 agtcatccac gggcactgtt atgggagctg ttatcatgga gggcttctac gttgtctttg
1681 atcgggcccg aaaacgaatt ggctttgctg tcagcgcttg ccatgtgcac gatgagttca
1741 ggacggcagc ggtggaaggc ccttttgtca ccttggacat ggaagactgt ggctacaaca
1801 ttccacagac agatgagtca accctcatga ccatagccta tgtcatggct gccatctgcg
1861 ccctcttcat gctgccactc tgcctcatgg tgtgtcagtg gcgctgcctc cgctgcctgc
1921 gccagcagca tgatgacttt gctgatgaca tctccctgct gaagtgagga ggcccatggg
1981 cagaagatag agattcccct ggaccacacc tccgtggttc actttggtca caagtaggag
2041 acacagatgg cacctgtggc cagagcacct caggaccctc cccacccacc aaatgcctct
2101 gccttgatgg agaaggaaaa ggctggcaag gtgggttcca gggactgtac ctgtaggaaa
2161 cagaaaagag aagaaagaag cactctgctg gcgggaatac tcttggtcac ctcaaattta
2221 agtcgggaaa ttctgctgct tgaaacttca gccctgaacc tttgtccacc attcctttaa
2281 attctccaac ccaaagtatt cttcttttct tagtttcaga agtactggca tcacacgcag
2341 gttaccttgg cgtgtgtccc tgtggtaccc tggcagagaa gagaccaagc ttgtttccct
2401 gctggccaaa gtcagtagga gaggatgcac agtttgctat ttgctttaga gacagggact
2461 gtataaacaa gcctaacatt ggtgcaaaga ttgcctcttg aattaaaaaa aaaaactaga
2521 ttgactattt atacaaatgg gggcggctgg aaagaggaga aggagaggga gtacaaagac
2581 agggaatagt gggatcaaag ctaggaaagg cagaaacaca accactcacc agtcctagtt
2641 ttagacctca tctccaagat agcatcccat ctcagaagat gggtgttgtt ttcaatgttt
2701 tcttttctgt ggttgcagcc tgaccaaaag tgagatggga agggcttatc tagccaaaga
2761 gctctttttt agctctctta aatgaagtgc ccactaagaa gttccactta acacatgaat
2821 ttctgccata ttaatttcat tgtctctatc tgaaccaccc tttattctac atatgatagg
2881 cagcactgaa atatcctaac cccctaagct ccaggtgccc tgtgggagag caactggact
2941 atagcagggc tgggctctgt cttcctggtc ataggctcac tctttccccc aaatcttcct
3001 ctggagcttt gcagccaagg tgctaaaagg aataggtagg agacctcttc tatctaatcc
3061 ttaaaagcat aatgttgaac attcattcaa cagctgatgc cctataaccc ctgcctggat
3121 ttcttcctat taggctataa gaagtagcaa gatctttaca taattcagag tggtttcatt
3181 gccttcctac cctctctaat ggcccctcca tttatttgac taaagcatca cacagtggca
3241 ctagcattat accaagagta tgagaaatac agtgctttat ggctctaaca ttactgcctt
3301 cagtatcaag gctgcctgga gaaaggatgg cagcctcagg gcttccttat gtcctccacc
3361 acaagagctc cttgatgaag gtcatctttt tcccctatcc tgttcttccc ctccccgctc
3421 ctaatggtac gtgggtaccc aggctggttc ttgggctagg tagtggggac caagttcatt
3481 acctccctat cagttctagc atagtaaact acggtaccag tgttagtggg aagagctggg
3541 ttttcctagt atacccactg catcctactc ctacctggtc aacccgctgc ttccaggtat
3601 gggacctgct aagtgtggaa ttacctgata agggagaggg aaatacaagg agggcctctg
3661 gtgttcctgg cctcagccag ctgcccacaa gccataaacc aataaaacaa gaatactgag
3721 tcagtttttt atctgggttc tcttcattcc cactgcactt ggtgctgctt tggctgactg
3781 ggaacacccc ataactacag agtctgacag gaagactgga gactgtccac ttctagctcg
3841 gaacttactg tgtaaataaa ctttcagaac tgctaaaaaa aaaaaaaaaa aaa
//