LOCUS BC063388 1825 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide
1, mRNA (cDNA clone MGC:74864 IMAGE:5170736), complete cds.
ACCESSION BC063388
VERSION BC063388.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1825)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1825)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 135 Row: b Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 13904854.
FEATURES Location/Qualifiers
source 1..1825
/db_xref="H-InvDB:HIT000260849"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:74864 IMAGE:5170736"
/tissue_type="Brain, adult medulla"
/clone_lib="NIH_MGC_119"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1825
/gene="CYP17A1"
/gene_synonym="CPT7"
/gene_synonym="P450C17"
/gene_synonym="S17AH"
/db_xref="GeneID:1586"
/db_xref="HGNC:HGNC:2593"
/db_xref="MIM:609300"
CDS 25..1551
/gene="CYP17A1"
/gene_synonym="CPT7"
/gene_synonym="P450C17"
/gene_synonym="S17AH"
/codon_start=1
/product="cytochrome P450, family 17, subfamily A,
polypeptide 1"
/protein_id="AAH63388.1"
/db_xref="GeneID:1586"
/db_xref="HGNC:HGNC:2593"
/db_xref="MIM:609300"
/translation="MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP
RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATL
DIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH
NGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLV
PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNG
NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ
NVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV
IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ
ELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
"
BASE COUNT 526 a 495 c 412 g 392 t
ORIGIN
1 cttgcctgcc ggcacccagc caccatgtgg gagctcgtgg ctctcttgct gcttacccta
61 gcttatttgt tttggcccaa gagaaggtgc cctggtgcca agtaccccaa gagcctcctg
121 tccctgcccc tggtgggcag cctgccattc ctccccagac acggccatat gcataacaac
181 ttcttcaagc tgcagaaaaa atatggcccc atctattcgg ttcgtatggg caccaagact
241 acagtgattg tcggccacca ccagctggcc aaggaggtgc ttattaagaa gggcaaggac
301 ttctctgggc ggcctcaaat ggcaactcta gacatcgcgt ccaacaaccg taagggtatc
361 gccttcgctg actctggcgc acactggcag ctgcatcgaa ggctggcgat ggccaccttt
421 gccctgttca aggatggcga tcagaagctg gagaagatca tttgtcagga aatcagtaca
481 ttgtgtgata tgctggccac ccacaacgga cagtccatag acatctcctt tcctgtcttc
541 gtggcggtaa ccaatgtcat ctccttgatc tgcttcaata cctcctacaa gaatggggac
601 cctgagttga atgtcataca gaattacaat gaaggcatca tagacaacct gagcaaagac
661 agcctggtgg acctagtccc ctggttgaag attttcccca acaaaaccct ggaaaaatta
721 aagagccatg ttaaaatacg aaatgatctg ctgaataaaa tacttgaaaa ttacaaggag
781 aaattccgga gtgactctat caccaacatg ctggacacac tgatgcaagc caagatgaac
841 tcagataatg gcaatgctgg cccagatcaa gactcagagc tgctttcaga taaccacatt
901 ctcaccacca taggggacat ctttggggct ggcgtggaga ccaccacctc tgtggttaaa
961 tggaccctgg ccttcctgct gcacaatcct caggtgaaga agaagctcta cgaggagatt
1021 gaccagaatg tgggtttcag ccgcacacca actatcagtg accgtaaccg tctcctcctg
1081 ctggaggcca ccatccgaga ggtgcttcgc ctcaggcccg tggcccctat gctcatcccc
1141 cacaaggcca acgttgactc cagcatcggt gagtttgctg tggacaaggg cacagaagtt
1201 atcatcaatc tgtgggcgct gcatcacaat gagaaggagt ggcaccagcc ggatcagttc
1261 atgcctgagc gtttcttgaa tccagcgggg acccagctca tctcaccgtc agtaagctat
1321 ttgcccttcg gagcaggacc tcgctcctgt ataggtgaga tcctggcccg ccaggagctc
1381 ttcctcatca tggcctggct gctgcagagg ttcgacctgg aggtgccaga tgatgggcag
1441 ctgccctccc tggaaggcat ccccaaggtg gtctttctga tcgactcttt caaagtgaag
1501 atcaaggtgc gccaggcctg gagggaagcc caggctgagg gtagcaccta aaggctgtaa
1561 ctcacagccc ctgtccaccc tatgtggccc cacaacacag atttagagat acaacccccc
1621 acccttctcc gccattcttc cctactccca acccactctg ccttcttttt cagcttgtgg
1681 caatgccagt gatgtgcata aacagttttt ttttttccaa aaaaaaaaaa aaaaaaaaaa
1741 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1801 aaaaaaaaaa aaaaaaaaaa aaaaa
//