LOCUS BC063293 4341 bp mRNA linear HUM 17-JUL-2006
DEFINITION Homo sapiens ADAM metallopeptidase with thrombospondin type 1
motif, 4, mRNA (cDNA clone MGC:71631 IMAGE:5303796), complete cds.
ACCESSION BC063293
VERSION BC063293.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4341)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4341)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-DEC-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 133 Row: p Column: 6
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 41327755.
FEATURES Location/Qualifiers
source 1..4341
/db_xref="H-InvDB:HIT000260814"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:71631 IMAGE:5303796"
/tissue_type="Brain, hypothalamus"
/clone_lib="NIH_MGC_96"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..4341
/gene="ADAMTS4"
/gene_synonym="ADAMTS-2"
/gene_synonym="ADAMTS-4"
/gene_synonym="ADMP-1"
/gene_synonym="KIAA0688"
/db_xref="GeneID:9507"
/db_xref="HGNC:HGNC:220"
/db_xref="MIM:603876"
CDS 426..2939
/gene="ADAMTS4"
/gene_synonym="ADAMTS-2"
/gene_synonym="ADAMTS-4"
/gene_synonym="ADMP-1"
/gene_synonym="KIAA0688"
/codon_start=1
/product="ADAM metallopeptidase with thrombospondin type 1
motif, 4"
/protein_id="AAH63293.1"
/db_xref="GeneID:9507"
/db_xref="HGNC:HGNC:220"
/db_xref="MIM:603876"
/translation="MSQIGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLAS
LLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGV
QVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAEL
HLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSR
FVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGE
EGPQVGPSAAQTLRSFCAWQRGLNTPENSDPDHFDTAILFTRQDLCGVSTCDTLGMAD
VGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNVLHDNSKPCISLNGPLSTSRHVMA
PVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQ
LTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLH
MDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVTRNGGKYCEGRRARF
RSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQ
AQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDG
SGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNG
EYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRY
SFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK"
BASE COUNT 867 a 1272 c 1243 g 959 t
ORIGIN
1 gggaacccac agggagaccc acagacacat atgcacgaga gagacagagg aggaaagaga
61 cagagacaaa ggcacagcgg aagaaggcag agacagggca ggcacagaag cggcccagac
121 agagtcctac agagggagag gccagagaag ctgcagaaga cacaggcagg gagagacaaa
181 gatccaggaa aggagggctc aggaggagag tttggagaag ccagacccct gggcacctct
241 cccaagccca aggactaagt tttctccatt tcctttaacg gtcctcagcc cttctgaaaa
301 ctttgcctct gaccttggca ggagtccaag cccccaggct acagagagga gctttccaaa
361 gctagggtgt ggaggacttg gtgccctaga cggcctcagt ccctcccagc tgcagtacca
421 gtgccatgtc ccagataggc tcgcatcccg ggaggggctt ggcagggcgc tggctgtggg
481 gagcccaacc ctgcctcctg ctccccattg tgccgctctc ctggctggtg tggctgcttc
541 tgctactgct ggcctctctc ctgccctcag cccggctggc cagccccctc ccccgggagg
601 aggagatcgt gtttccagag aagctcaacg gcagcgtcct gcctggctcg ggcgcccctg
661 ccaggctgtt gtgccgcttg caggcctttg gggagacgct gctactagag ctggagcagg
721 actccggtgt gcaggtcgag gggctgacag tgcagtacct gggccaggcg cctgagctgc
781 tgggtggagc agagcctggc acctacctga ctggcaccat caatggagat ccggagtcgg
841 tggcatctct gcactgggat gggggagccc tgttaggcgt gttacaatat cggggggctg
901 aactccacct ccagcccctg gagggaggca cccctaactc tgctggggga cctggggctc
961 acatcctacg ccggaagagt cctgccagcg gtcaaggtcc catgtgcaac gtcaaggctc
1021 ctcttggaag ccccagcccc agaccccgaa gagccaagcg ctttgcttca ctgagtagat
1081 ttgtggagac actggtggtg gcagatgaca agatggccgc attccacggt gcggggctaa
1141 agcgctacct gctaacagtg atggcagcag cagccaaggc cttcaagcac ccaagcatcc
1201 gcaatcctgt cagcttggtg gtgactcggc tagtgatcct ggggtcgggc gaggaggggc
1261 cccaagtggg gcccagtgct gcccagaccc tgcgcagctt ctgtgcctgg cagcggggcc
1321 tcaacacccc tgagaactcg gaccctgacc actttgacac agccattctg tttacccgtc
1381 aggacctgtg tggagtctcc acttgcgaca cgctgggtat ggctgatgtg ggcaccgtct
1441 gtgacccggc tcggagctgt gccattgtgg aggatgatgg gctccagtca gccttcactg
1501 ctgctcatga actgggtcat gtcttcaacg tgctccatga caactccaag ccatgcatca
1561 gtttgaatgg gcctttgagc acctctcgcc atgtcatggc ccctgtgatg gctcatgtgg
1621 atcctgagga gccctggtcc ccctgcagtg cccgcttcat cactgacttc ctggacaatg
1681 gctatgggca ctgtctctta gacaaaccag aggctccatt gcatctgcct gtgactttcc
1741 ctggcaagga ctatgatgct gaccgccagt gccagctgac cttcgggccc gactcacgcc
1801 attgtccaca gctgccgccg ccctgtgctg ccctctggtg ctctggccac ctcaatggcc
1861 atgccatgtg ccagaccaaa cactcgccct gggccgatgg cacaccctgc gggcccgcac
1921 aggcctgcat gggtggtcgc tgcctccaca tggaccagct ccaggacttc aatattccac
1981 aggctggtgg ctggggtcct tggggaccat ggggtgactg ctctcggacc tgtgggggtg
2041 gtgtccagtt ctcctcccga gactgcacga ggcctgtcac ccggaatggt ggcaagtact
2101 gtgagggccg ccgtgcccgc ttccgctcct gcaacactga ggactgccca actggctcag
2161 ccctgacctt ccgcgaggag cagtgtgctg cctacaacca ccgcaccgac ctcttcaaga
2221 gcttcccagg gcccatggac tgggttcctc gctacacagg cgtggccccc caggaccagt
2281 gcaaactcac ctgccaggcc caggcactgg gctactacta tgtgctggag ccacgggtgg
2341 tagatgggac cccctgttcc ccggacagct cctcggtctg tgtccagggc cgatgcatcc
2401 atgctggctg tgatcgcatc attggctcca agaagaagtt tgacaagtgc atggtgtgcg
2461 gaggggacgg ttctggttgc agcaagcagt caggctcctt caggaaattc aggtacggat
2521 acaacaatgt ggtcactatc cccgcggggg ccacccacat tcttgtccgg cagcagggaa
2581 accctggcca ccggagcatc tacttggccc tgaagctgcc agatggctcc tatgccctca
2641 atggtgaata cacgctgatg ccctccccca cagatgtggt actgcctggg gcagtcagct
2701 tgcgctacag cggggccact gcagcctcag agacactgtc aggccatggg ccactggccc
2761 agcctttgac actgcaagtc ctagtggctg gcaaccccca ggacacacgc ctccgataca
2821 gcttcttcgt gccccggccg accccttcaa cgccacgccc cactccccag gactggctgc
2881 accgaagagc acagattctg gagatccttc ggcggcgccc ctgggcgggc aggaaataac
2941 ctcactatcc cggctgccct ttctgggcac cggggcctcg gacttagctg ggagaaagag
3001 agagcttctg ttgctgcctc atgctaagac tcagtgggga ggggctgtgg gcgtgagacc
3061 tgcccctcct ctctgcccta atgcgcaggc tggccctgcc ctggtttcct gccctgggag
3121 gcagtgatgg gttagtggat ggaaggggct gacagacagc cctccatcta aactgccccc
3181 tctgccctgc gggtcacagg agggaggggg aaggcaggga gggcctgggc cccagttgta
3241 tttatttagt atttattcac ttttatttag caccagggaa ggggacaagg actagggtcc
3301 tggggaacct gacccctgac ccctcatagc cctcaccgtg gggctaggaa atccagggtg
3361 gtggtgatag gtataagtgg tgtgtgtatg cgtgtgtgtg tgtgtgaaaa tgtgtgtgtg
3421 cttatgtatg aggtacaacc tgttctgctt tcctcttcct gaattttatt ttttgggaaa
3481 agaaaagtca agggtagggt gggccttcag ggagtgaggg attatctttt tttttttttt
3541 ctttctttct ttcttttttt tttttgagac agaatctcgc tctgtcgccc aggctggagt
3601 gcaatggcac aatctcggct cactgcatcc tccgcctccc gggttcaagt gattctcatg
3661 cctcagcctc ctgagtagct gggattacag gctcctgcca ccacgcccgg ctaatttttg
3721 ttttgttttg tttggagaca gagtctcgct attgtcacca gggctggaat gatttcagct
3781 cactgcaacc ttcgccacct gggttccagc aattctcctg cctcagcctc ccgagtagct
3841 gagattatag gcacctacca ccacgcccgg ctaatttttg tatttttagt agagacgggg
3901 tttcaccatg ttggccaggc tggtctcgaa ctcctgacct taggtgatcc actcgccttc
3961 atctcccaaa gtgctgggat tacaggcgtg agccaccgtg cctggccacg cccaactaat
4021 ttttgtattt ttagtagaga cagggtttca ccatgttggc caggctgctc ttgaactcct
4081 gacctcaggt aatcgacctg cctcggcctc ccaaagtgct gggattacag gtgtgagcca
4141 ccacgcccgg tacatatttt ttaaattgaa ttctactatt tatgtgatcc ttttggagtc
4201 agacagatgt ggttgcatcc taactccatg tctctgagca ttagatttct catttgccaa
4261 taataatacc tcccttagaa gtttgttgtg aggattaaat aatgtaaata aagaactagc
4321 ataacaaaaa aaaaaaaaaa a
//