LOCUS BC058938 2802 bp mRNA linear HUM 30-MAR-2004
DEFINITION Homo sapiens leucine zipper, putative tumor suppressor 2, mRNA
(cDNA clone MGC:65190 IMAGE:3913470), complete cds.
ACCESSION BC058938
VERSION BC058938.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2802)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2802)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (01-OCT-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steve Jones, Sarah Barber, Mabel Brown-John, Yaron Butterfield,
Andy Chan, Steve S. Chand, William Chow, Alison Cloutier, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Amara Masson, Mike R. Mayo, Josh Moran, Ryan Morin,
Teika Olson, Diana Palmquist, Anca Petrescu, Anna Liisa Prahbu,
Parvaneh Saeedi, JR Santos, Angelique Schnerch, Ursula Skalska,
Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie
Schein, Asim Siddiqui, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 119 Row: a Column: 15
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis, GenomeScan gene prediction.
FEATURES Location/Qualifiers
source 1..2802
/db_xref="H-InvDB:HIT000259947"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:65190 IMAGE:3913470"
/tissue_type="Uterus, leiomyosarcoma"
/clone_lib="NIH_MGC_71"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2802
/gene="LZTS2"
/gene_synonym="KIAA1813"
/gene_synonym="LAPSER1"
/db_xref="GeneID:84445"
CDS 145..2154
/gene="LZTS2"
/gene_synonym="KIAA1813"
/gene_synonym="LAPSER1"
/codon_start=1
/product="LZTS2 protein"
/protein_id="AAH58938.1"
/db_xref="GeneID:84445"
/translation="MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAP
PRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPS
PSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPS
LPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLS
DSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRS
SSSKSTGSLGGRLAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLR
DREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL
QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEI
SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA
CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAG
VGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQM
YRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI"
misc_feature 1459..2019
/gene="LZTS2"
/gene_synonym="KIAA1813"
/gene_synonym="LAPSER1"
/note="Fez1; Region: Fez1. This family represents the
eukaryotic Fez1 protein. Fez1 contains a leucine-zipper
region with similarity to the DNA-binding domain of the
cAMP-responsive activating-transcription factor 5. There
is evidence that Fez1 inhibits cancer cell growth through
regulation of mitosis, and that its alterations result in
abnormal cell growth. Note that some family members
contain more than one copy of this region"
/db_xref="CDD:pfam06818"
BASE COUNT 531 a 892 c 922 g 457 t
ORIGIN
1 gccggggccg gggccggggc cggagccgga gccggggccg ggcggcgcgc ctgtggagcg
61 ctgggggcgg cctggggctg agcatggagc agcgcggcgg aggtcgcctg cgaggccgct
121 ggccaggcct gagcctctgc caccatggcc attgtgcaga ctctgccagt gccactggag
181 cctgctcctg aagctgccac tgccccacaa gctccagtca tgggtagtgt gagcagcctt
241 atctcaggcc ggccctgtcc cggggggcca gctcctcccc gccaccacgg ccctcctggg
301 cccaccttct tccgccagca ggatggcctg ctacggggtg gctatgaggc acaggagccg
361 ctgtgcccag ctgtgccccc taggaaggct gtccctgtca ccagcttcac ctacatcaat
421 gaggacttcc ggacagagtc accccccagc ccaagcagtg atgttgagga tgcccgagag
481 cagcgggcac acaatgccca cctccgcggc ccaccaccaa agctcatccc tgtctctgga
541 aagctggaga agaacatgga gaagatcctg atccgcccaa cagccttcaa gccagtgctg
601 cccaaacctc gaggggctcc gtccctgcct agcttcatgg gtcctcgggc caccgggctg
661 tctgggagcc agggcagcct gacgcagctg tttgggggcc ctgcctcctc ctcctcctct
721 tcctcctcct cttcagctgc tgacaaaccc ctggcattta gtggctgggc cagtggctgc
781 ccatcaggga cgctatccga ctctggccga aactcactgt ccagcctgcc cacctacagc
841 accggaggtg ccgagccaac caccagctcc ccaggcgggc acctgccttc ccatggctct
901 gggcgagggg cactgcctgg gccagcccga ggggtcccta ctgggccctc ccactcagac
961 agtggccggt cctcctccag caagagcaca ggctccctag ggggccgttt ggctgggggg
1021 cttttgggca gtggtactcg ggcctcccct gacagcagct cctgtgggga gcgctcacca
1081 ccacccccgc ctccacctcc ttcggatgag gccctgctgc actgtgtcct ggaaggaaag
1141 ctccgagacc gggaggcaga gcttcagcag ctgcgggaca gtctggacga gaatgaggct
1201 accatgtgcc aggcatacga ggagcggcag cggcactggc agcgagagcg tgaggccctg
1261 cgagaggact gtgcggccca ggcacagcgg gcacagcggg cccaacagct gctgcagctg
1321 caggtgttcc agctgcagca ggagaagcgg caattgcagg atgacttcgc acagctgctg
1381 caggagcgcg aacagctgga gcggcgctgc gccaccttgg agcgggagca gcgggagctc
1441 gggccgaggc ttgaggagac caagtgggag gtgtgccaga aatcaggcga gatctccctg
1501 ctgaagcagc agctgaaaga gtctcaggca gagctggtgc agaagggcag cgagctggtg
1561 gctctgcggg tggcgctgcg ggaggcccgt gctacgctgc gggtcagtga gggccgtgcg
1621 cggggtctac aggaggccgc ccgagctcgg gagctggagc tggaagcctg ttcccaggag
1681 ctgcagcgac accgccagga agctgagcag ctgcgggaga aagctgggca gttggatgct
1741 gaggcggccg gactccggga gccccctgtg ccacctgcca ccgctgaccc attcctcctg
1801 gcggagagtg atgaggccaa agtgcagcgg gcagcagccg gggttggggg cagcttgcgg
1861 gcccaggtgg agcgattgcg ggtggagctg cagcgggagc ggcggcgggg tgaggagcag
1921 cgggacagct ttgaggggga gcggctggcc tggcaggcag agaaggagca ggtgatccgc
1981 taccagaagc agctgcagca caactacatc cagatgtacc ggcgcaaccg gcagctagag
2041 caggagctgc agcagctcag cctggagctg gaggcccggg agctcgctga cctgggcctg
2101 gccgagcagg ccccctgcat ctgcctggag gagatcactg ctactgagat ctagggccct
2161 cagcaaccag ctctgtaggg agctctgcca gaggggcagc agctgcagat ccacttaggc
2221 cccagggtcc acggatggcc ccaaaggctg agggccccaa agccacttgt ctcctaggat
2281 ccaggcctct gggcttctgc caagaactca gggtggccct atgacttgga ggagcaagat
2341 cagacagctc aaaggtcccc gtgttcactg ttacccagag gctgttgtta ctacccactt
2401 cattccccac cgctgccagt gccactgcca accctgttca caggcgcttc cagcccactc
2461 cagccagggg agcagggaag aagaaggggc tccctcctct tcacattccc cccgacccca
2521 aagccagaga aagccagatg gcaccagctg ctccggatgt gcctgcccac attgggggac
2581 agggccgggc ctgggctcgg ttcccaggtt tgagctctgc agcctctctc ctggagtgag
2641 ggggctgaag tcagaccaaa ggaagaactc agaaatgtct tgtttatttg tgtttgtgac
2701 caagcagcct ctcccttcac ccaggtttat ggcctcgttt tcacttgtat atttttcaca
2761 ctgtaaattt cttgtacaaa cccaaagaaa aaaaaaaaaa aa
//