LOCUS BC058916 1235 bp mRNA linear HUM 04-NOV-2003
DEFINITION Homo sapiens serine/threonine kinase 4, mRNA (cDNA clone
IMAGE:4390245), partial cds.
ACCESSION BC058916
VERSION BC058916.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1235)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1235)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (01-OCT-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 119 Row: a Column: 22
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 5454095.
FEATURES Location/Qualifiers
source 1..1235
/db_xref="H-InvDB:HIT000259926"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4390245"
/tissue_type="Bone, osteosarcoma"
/clone_lib="NIH_MGC_86"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..>1235
/gene="STK4"
/gene_synonym="KRS2"
/gene_synonym="MST1"
/db_xref="GeneID:6789"
/db_xref="MIM:604965"
CDS 20..>1235
/gene="STK4"
/gene_synonym="KRS2"
/gene_synonym="MST1"
/codon_start=1
/product="STK4 protein"
/protein_id="AAH58916.1"
/db_xref="GeneID:6789"
/db_xref="MIM:604965"
/translation="METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSV
YKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVM
EYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE
GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMA
EGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLL
QHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAV
GDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAK
PSFLEYFEQKKKK"
misc_feature 107..862
/gene="STK4"
/gene_synonym="KRS2"
/gene_synonym="MST1"
/note="S_TKc; Region: Serine/Threonine protein kinases,
catalytic domain. Phosphotransferases of the serine or
threonine-specific kinase subfamily. The enzymatic
activity of these protein kinases is controlled by
phosphorylation of specific residues in the activation
segment of the catalytic domain, sometimes combined with
reversible conformational changes in the C-terminal
autoregulatory tail"
/db_xref="CDD:cd00180"
BASE COUNT 414 a 243 c 302 g 276 t
ORIGIN
1 ggcggctgct ggcagcgcca tggagacggt acagctgagg aacccgccgc gccggcagct
61 gaaaaagttg gatgaagata gtttaaccaa acaaccagaa gaagtatttg atgtcttaga
121 gaaacttgga gaagggtcct atggcagcgt atacaaagct attcataaag agaccggcca
181 gattgttgct attaagcaag ttcctgtgga atcagacctc caggagataa tcaaagaaat
241 ctctataatg cagcaatgtg acagccctca tgtagtcaaa tattatggca gttattttaa
301 gaacacagac ttatggatcg ttatggagta ctgtggggct ggttctgtat ctgatatcat
361 tcgattacga aataaaacgt taacagaaga tgaaatagct acaatattac aatcaactct
421 taagggactt gaataccttc attttatgag aaaaatacac cgagatatca aggcaggaaa
481 tattttgcta aatacagaag gacatgcaaa acttgcagat tttggggtag caggtcaact
541 tacagatacc atggccaagc ggaatacagt gataggaaca ccattttgga tggctccaga
601 agtgattcag gaaattggat acaactgtgt agcagacatc tggtccctgg gaataactgc
661 catagaaatg gctgaaggaa agccccctta tgctgatatc catccaatga gggcaatctt
721 catgattcct acaaatcctc ctcccacatt ccgaaaacca gagctatggt cagataactt
781 tacagatttt gtgaaacagt gtcttgtaaa gagccctgag cagagggcca cagccactca
841 gctcctgcag cacccatttg tcaggagtgc caaaggagtg tcaatactgc gagacttaat
901 taatgaagcc atggatgtga aactgaaacg ccaggaatcc cagcagcggg aagtggacca
961 ggacgatgaa gaaaactcag aagaggatga aatggattct ggcacgatgg ttcgagcagt
1021 gggtgatgag atgggcactg tccgagtagc cagcaccatg actgatggag ccaatactat
1081 gattgagcac gatgacacgt tgccatcaca actgggcacc atggtgatca atgcagagga
1141 tgaggaagag gaaggaacta tgaaaagaag ggatgagacc atgcagcctg cgaaaccatc
1201 ctttcttgaa tattttgaac aaaaaaaaaa aaaaa
//