LOCUS BC054486 4496 bp mRNA linear HUM 28-JUL-2005
DEFINITION Homo sapiens pleckstrin homology domain containing, family G (with
RhoGef domain) member 4, mRNA (cDNA clone MGC:51096 IMAGE:4820741),
complete cds.
ACCESSION BC054486
VERSION BC054486.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4496)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4496)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-JUL-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 90 Row: f Column: 14.
FEATURES Location/Qualifiers
source 1..4496
/db_xref="H-InvDB:HIT000259447"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:51096 IMAGE:4820741"
/tissue_type="Brain, hippocampus"
/clone_lib="NIH_MGC_95"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..4496
/gene="PLEKHG4"
/gene_synonym="DKFZP434I216"
/gene_synonym="puratrophin1"
/db_xref="GeneID:25894"
CDS 457..3789
/gene="PLEKHG4"
/gene_synonym="DKFZP434I216"
/gene_synonym="puratrophin1"
/codon_start=1
/product="PLEKHG4 protein"
/protein_id="AAH54486.1"
/db_xref="GeneID:25894"
/translation="MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVK
DPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGV
ESLLCPMSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRP
EVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLE
QLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIES
VKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSP
DYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVG
LPALEEAGEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARF
LALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQ
QLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASL
KLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRP
EAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELD
RPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMY
ALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR
ACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRT
GRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIW
FRGRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRD
IAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPGDPASCSVLGS
LNLHLYRDPALLGLRCPLYPSFPEEAALEAEAELGGQPSLTAEDSEISSQCPSASGSS
GSDSSCVSGQALGRGLEDLPCV"
BASE COUNT 867 a 1361 c 1390 g 878 t
ORIGIN
1 gttcgacttc acggttcccc gcggctcggc ccgggggcgt gagtgtcgcc agcgggcgac
61 gggggggcgc gcggtaggcc ctgcaacaag gccagggcct gggggggccg gcaggagagc
121 gaacccgagg catcgtggtg ccatggcggg gccgccccca cgggcatggg cctgcagagc
181 gtggccgtga ggacgctgag ggtgggcgcg cacggagcag aggcccacgg gcgtccgacg
241 ggggacctgg acagagggac acccttaacg ttattccctc ttcccaggcc tgaattgcag
301 ttcctgtgcc ctggcactaa gactggcacc tcctgcggcc catgcccttc gcctgcattg
361 cccactgagt cccactcgac tgtcttcagc gcggttcaca ctgagaccca gccctctccc
421 gctggccccg agcaggccca cctttaggag ggcgtgatgg aaaggcccct ggagaatggg
481 gatgagtccc cagactctca gggccatgca accgactgga gatttgctgt gtgcagtttc
541 agggatgcct gggaagagga ggaacctgct tcccagatgc acgttaagga cccaggtcct
601 ccaagaccac cagccggggc cacccaggat gaggagctac agggcagccc cttgtccagg
661 aaattccagt tacccccagc tgcagatgag tcgggggatg cccagagggg cacagtagaa
721 agctcctcag tcctgtcaga agggccaggc ccctctggag tggagagtct cctatgcccc
781 atgtcctccc acctcagctt ggcacagggg actcgggatg tccaaggccg ggcagtgctg
841 cttctgtgtg cccacagccc agcctggctt cagtctgagt gcagcagcca ggaactcatc
901 cgcctcctgc tgtacctgcg aagcatcccc aggcccgaag tacaggcact gggactgaca
961 gtgctagttg atgcccgaat ttgtgctcca agttcttccc tcttctctgg gctcagccaa
1021 ctacaagaag cagccccagg ggccgtgtac caggtgctgc tagtgggaag cacgctgctg
1081 aaggaagtgc cttccgggct gcagctggag cagttgcctt ctcagagcct gctgacccac
1141 atcccaacgg cggggctgcc cacttcgcta ggaggaggcc tgccttactg ccaccaggcc
1201 tggctggatt tccgaaggcg gctggaagct ctactacaga actgccaggc agcttgtgcc
1261 ctgctccagg gggccatcga aagtgtgaag gctgtgcccc agcccatgga gcctggggag
1321 gtcggtcagc tgctacagca gacagaggtc ctgatgcagc aggtgctaga ctcgccatgg
1381 ctggcatggc tacaatgcca ggggggccgg gagctgacat ggctgaagca agaggtccca
1441 gaggtgaccc tgagcccaga ctacaggacg gcaatggaca aggctgacga gctatatgac
1501 cgggtggatg gattgctgca ccaactgacc ctgcagagca accagcgaat acaggcccta
1561 gagttggtcc aaacactgga ggcccgggaa agcggactgc accagattga agtgtggctg
1621 cagcaggtgg gcttgccagc actggaggag gctggggagc cctcgctgga catgctgctc
1681 caggcccaag gctcttttca ggagctgtac caggttgccc aggagcaggt caggcaaggg
1741 gagaagtttc tgcagccgct gactggctgg gaggcggctg aactggaccc ccctggggca
1801 cgctttctgg ccctgcgagc ccagctgact gaattctcta gggctttggc ccagcggtgc
1861 cagcggctgg cggatgctga gaggctgttt cagctcttca gggaggcctt gacgtgggct
1921 gaggaggggc agcgagtgtt ggcagagctg gagcaggaac gcccgggggt tgtgttgcag
1981 cagctgcagc tgcactggac caggcaccct gacttgcctc ctgcccactt ccgaaagatg
2041 tgggctctgg ccacggggct gggctcagag gccatccgcc aggagtgccg ctgggcctgg
2101 gcgcggtgcc aggacacctg gctggccctg gaccaaaagc ttgaggcttc actgaagcta
2161 ccaccggtgg gcagcacagc tagcctgtgt gtcagccagg tccccgctgc acctgcccac
2221 cctcccctga ggaaggccta cagcttcgat cggaatctgg ggcagagtct cagtgaacct
2281 gcctgccact gccaccatgc ggccactatt gctgcctgcc gcagaccaga ggctggagga
2341 ggtgccctgc cccaggcatc ccctactgtg cctccaccag gcagctctga ccccaggagc
2401 ctcaacaggc tacagctggt gctggcagag atggtggcca cggagcggga gtatgtccgg
2461 gctctagagt acactatgga gaactatttc cccgagctgg atcgccccga tgtgccccag
2521 ggcctccgcg gtcagcgtgc ccacctcttt ggcaacctgg agaagctgcg ggacttccac
2581 tgccacttct tcctgcgtga gctggaggct tgcacccggc acccaccacg agtggcctat
2641 gccttcctgc gccatagggt gcagtttggg atgtacgcgc tctacagcaa gaataagcct
2701 cgctccgatg ccctgatgtc aagctatggg cacaccttct tcaaggacaa gcagcaagca
2761 ctgggggacc acctggacct ggcctcctac ctgctaaagc ccatccagcg catgggcaag
2821 tacgcactgc tgctgcagga gctggcacgg gcctgcgggg gccccacgca ggagctcagt
2881 gcgctgcggg aggcccagag ccttgtgcac ttccagctgc ggcacggaaa cgacctgctg
2941 gccatggacg ccatccaggg ctgtgatgtt aacctcaagg aacaggggca gctggtgcga
3001 caggatgagt ttgtggtgcg cactgggcgc cacaagtccg tgcgccgcat cttccttttt
3061 gaggagctgc tgctcttcag caagcctcgc catgggccca caggggttga cacatttgcc
3121 tacaagcgct ccttcaagat ggcagacctt ggtctcactg agtgctgtgg gaacagcaac
3181 ctgcgcttcg agatctggtt ccgcggccgc aaggccaggg acacctttgt gctgcaggcc
3241 tccagcctgg ctatcaagca ggcctggaca gctgacatct cccacctgct ttggaggcag
3301 gccgtccaca acaaggaggt gcgcatggct gagatggtgt ccatgggtgt ggggaacaag
3361 gccttccgag acattgctcc cagcgaggaa gccatcaacg accgcaccgt caactatgtc
3421 ctgaagtgcc gagaagttcg ctctcgggcg tccattgccg tagccccgtt tgaccatgac
3481 agcctctacc tgggggcctc gaactccctt cctggagacc ctgcctcttg ctctgttctg
3541 gggtccctca acctgcacct gtacagagac ccagctcttc tgggtctccg ctgtcccctg
3601 tatcccagct tcccagagga agcagcactg gaggctgagg cagagctggg cggccagccc
3661 tctttgactg ctgaggactc agagatctcg tcccaatgcc catcagccag tggctccagt
3721 ggctctgaca gcagctgtgt gtcagggcag gccctgggta ggggcctgga ggacttaccc
3781 tgtgtctgag cccgggactg gacgagcagt agatccagca gcctgcagct ccaaggaaca
3841 ttgcctctct ggatctgctg tgaccagggt gtggctgaca cctgggctac ctccaaccta
3901 catgtgcaac gctgttgact accctttctg atgtgtgtgg ccattggact aactggcacg
3961 gggcctctct agggaagtct ggttgtagag cctgaatagg ctcctggccc catgacccct
4021 tctcctgtcc ccagctccca tcccagttgt gggttaagaa taggctagag cagacattgg
4081 gtgtttccat gctgtaggct ggtgggggac catgtgcctc taggcagtga ctagggtgcc
4141 cccacccctc aggaagaaca caggtgggct cctagcagct gatccccaat gcctggcctt
4201 aaagccgagc tcagttacca tagggacagg tccacctcta ctaggccctc atgcttgcct
4261 ttcctggccc ccaggcccag ccccttttta ctggggcagt ttcgttattt tgacttgatg
4321 ccttttgaat aactttcaat agaattgtct aaaattatct tactggttgt taggcctttg
4381 gtgtctcaga gaaggagtct aggtctttga tgtgtgattt aatcttttat ttgtttataa
4441 taaaaaatag actgatatgt accctctgat gggcacatgc aaaaaaaaaa aaaaaa
//