LOCUS BC052589 1595 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens lymphocyte-activation gene 3, mRNA (cDNA clone
MGC:59698 IMAGE:6301931), complete cds.
ACCESSION BC052589
VERSION BC052589.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1595)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1595)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (16-MAY-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. Mark Watson
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 47 Row: j Column: 5
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 15718681.
FEATURES Location/Qualifiers
source 1..1595
/db_xref="H-InvDB:HIT000053804"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:59698 IMAGE:6301931"
/tissue_type="Spleen"
/clone_lib="NIH_MGC_113"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1595
/gene="LAG3"
/gene_synonym="CD223"
/db_xref="GeneID:3902"
/db_xref="MIM:153337"
CDS 335..1417
/gene="LAG3"
/gene_synonym="CD223"
/codon_start=1
/product="LAG3 protein"
/protein_id="AAH52589.1"
/db_xref="GeneID:3902"
/db_xref="MIM:153337"
/translation="MWEAQFLGLLFLQPLWVAPVKPLQPGAEVPVVWAQEGAPAQLPC
SPTIPLQDLSLLRRAGVTWQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVL
SVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSC
RLRLRLGQASMTASPPGSLRASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPH
HHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGS
RVGLPCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCH
IHLQEQQLNATVTLAIITGQPQVGKE"
misc_feature 1133..1378
/gene="LAG3"
/gene_synonym="CD223"
/note="IG; Region: Immunoglobulin"
/db_xref="CDD:smart00409"
BASE COUNT 270 a 599 c 426 g 300 t
ORIGIN
1 cagagaccag cagaacggca tcccagccac gacggccact ttgctctgtc tgctctccgc
61 cacggccctg ctctgttccc tgggacaccc ccgcccccac ctcctcaggc tgcctgatct
121 gcccagcttt ccagctttcc tctggattcc ggcctctggt catccctccc caccctctct
181 ccaaggccct ctcctggtct cccttcttct agaacccctt cctccacctc cctctctgca
241 gaacttctcc tttacccccc accccccacc actgccccct ttccttttct gacctccttt
301 tggagggctc agcgctgccc agaccatagg agagatgtgg gaggctcagt tcctgggctt
361 gctgtttctg cagccgcttt gggtggctcc agtgaagcct ctccagccag gggctgaggt
421 cccggtggtg tgggcccagg agggggctcc tgcccagctc ccctgcagcc ccacaatccc
481 cctccaggat ctcagccttc tgcgaagagc aggggtcact tggcagcatc agccagacag
541 tggcccgccc gctgccgccc ccggccatcc cctggccccc ggccctcacc cggcggcgcc
601 ctcctcctgg gggcccaggc cccgccgcta cacggtgctg agcgtgggtc ccggaggcct
661 gcgcagcggg aggctgcccc tgcagccccg cgtccagctg gatgagcgcg gccggcagcg
721 cggggacttc tcgctatggc tgcgcccagc ccggcgcgcg gacgccggcg agtaccgcgc
781 cgcggtgcac ctcagggacc gcgccctctc ctgccgcctc cgtctgcgcc tgggccaggc
841 ctcgatgact gccagccccc caggatctct cagagcctcc gactgggtca ttttgaactg
901 ctccttcagc cgccctgacc gcccagcctc tgtgcattgg ttccggaacc ggggccaggg
961 ccgagtccct gtccgggagt ccccccatca ccacttagcg gaaagcttcc tcttcctgcc
1021 ccaagtcagc cccatggact ctgggccctg gggctgcatc ctcacctaca gagatggctt
1081 caacgtctcc atcatgtata acctcactgt tctgggtctg gagcccccaa ctcccttgac
1141 agtgtacgct ggagcaggtt ccagggtggg gctgccctgc cgcctgcctg ctggtgtggg
1201 gacccggtct ttcctcactg ccaagtggac tcctcctggg ggaggccctg acctcctggt
1261 gactggagac aatggcgact ttacccttcg actagaggat gtgagccagg cccaggctgg
1321 gacctacacc tgccatatcc atctgcagga acagcagctc aatgccactg tcacattggc
1381 aatcatcaca ggtcagcctc aggtgggaaa ggagtagctg ccctcccagg gtagaaagga
1441 cagggaggaa gggctggcag ggcaaagact aggcaaaccc accctgtgat gccaggccac
1501 tgggcacaag ttccagagcc tgcccatctc ggcccccact tttctcaccc ccataataaa
1561 gaaacgaaac tgaaaaaaaa aaaaaaaaaa aaaaa
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