LOCUS BC051838 2226 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens Rho guanine exchange factor (GEF) 16, mRNA (cDNA clone
MGC:60142 IMAGE:6191377), complete cds.
ACCESSION BC051838
VERSION BC051838.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2226)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2226)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (01-MAY-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. James R. Lupski
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 110 Row: n Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 15011976.
FEATURES Location/Qualifiers
source 1..2226
/db_xref="H-InvDB:HIT000053701"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:60142 IMAGE:6191377"
/tissue_type="Peripheral Nervous System, sympathetic
trunk"
/clone_lib="Lupski_sympathetic_trunk"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2226
/gene="ARHGEF16"
/gene_synonym="GEF16"
/gene_synonym="NBR"
/db_xref="GeneID:27237"
CDS 420..1685
/gene="ARHGEF16"
/gene_synonym="GEF16"
/gene_synonym="NBR"
/codon_start=1
/product="ARHGEF16 protein"
/protein_id="AAH51838.1"
/db_xref="GeneID:27237"
/translation="MFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNI
LDVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQK
LISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERY
KAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRG
ELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEP
SELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQW
QGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFP
EDFARFITSRVAVEGNVRRMERLRVETDV"
misc_feature 420..956
/gene="ARHGEF16"
/gene_synonym="GEF16"
/gene_synonym="NBR"
/note="RhoGEF; Region: Guanine nucleotide exchange factor
for Rho/Rac/Cdc42-like GTPases"
/db_xref="CDD:smart00325"
BASE COUNT 471 a 672 c 702 g 381 t
ORIGIN
1 cgtgaggccc tgtggagctg acatctattg ggcacagctt cgcatgtgga gccgagaggt
61 ctctggggtc ccagggcaga atcgccgtgg gcaacacctg ccccggctga cagctgcggt
121 ttctgtgtct ctcttttgtg cagaagacgc tggggaggaa acgtgggcac aagggttcct
181 tcaaggacga cccccagctc taccaggaga tccaggagcg gggcctgaac accagccagg
241 agtctgatga cgacatcctc gatgagtcct ccagccccga gggaacccag aaggtggacg
301 ccaccattgt ggtcaagagc taccggcccg cccaggtcac ctggagccag ctcccggagg
361 tggtggaatt gggcatcctg gaccagctct ccactgagga gcggaaaagg caggaggcca
421 tgttcgagat cctcacgtcg gagttctcct accagcacag cctgagcatc ctggtggagg
481 agttcctgca gtccaaggag ctgcgggcga ccgtgaccca gatggagcac caccacctct
541 tctccaacat cctggatgtc ctgggtgcca gtcagaggtt cttcgaggac ctggagcagc
601 ggcacaaggc ccaggtgctg gtcgaggaca tcagtgacat cctggaggag cacgctgaga
661 agcacttcca cccctacatc gcctactgct ccaacgaggt ctaccaacag cgcacgctgc
721 agaagctgat aagcagcaac gccgccttcc gagaggccct gagagagatt gagaggcggc
781 cggcgtgcgg gggcctgccc atgctctcct tcctgatcct ccccatgcag cgggtgaccc
841 ggctgcccct cctgatggat acgctctgcc tcaagaccca gggccactcc gaaaggtaca
901 aggctgccag ccgtgcactg aaggccatca gcaagctggt gaggcagtgc aacgaggggg
961 cccacaggat ggagcgcatg gagcagatgt acacgctgca cacacagctg gacttcagca
1021 aggtcaagtc tctcccactg atctccgcct cccggtggct gctgaagcgc ggagagctgt
1081 tcttagtgga agaaaccgga ctttttcgaa aaattgccag ccggccaacg tgctaccttt
1141 tcctgttcaa cgatgtcctg gttgtgacca agaagaagag cgaggagagc tacatggtcc
1201 aggactacgc ccagatgaac cacatccagg tggagaagat agagccgtct gagctccctc
1261 tgcccggggg cggcaaccgt agctcctccg tgccccaccc cttccaggtg accctgcttc
1321 gcaacagcga gggccgccag gagcagctcc tgctctcctc ggactccgcg agtgaccggg
1381 cacggtggat cgtggcgctc acacacagtg agagacagtg gcagggcctc tccagcaaag
1441 gagacctgcc ccaggtggag atcaccaagg ccttcttcgc gaagcaagca gacgaggtca
1501 cactgcagca ggcggacgtg gtcctggttc tgcagcagga ggatgggtgg ctctatggcg
1561 agaggctccg ggacggagag acgggatggt tccccgagga ctttgcccgc ttcatcacca
1621 gccgtgtggc cgtggagggc aatgtccgca ggatggagcg tctgcgggtg gagacggacg
1681 tgtagccctg gcgaggccag ccggcggcag cacagcctgt ccccaatcag caagtggtcg
1741 tgcctggctc tagagagcgt ggggagctgg tctcaaggac ccagcatggt tccctggggc
1801 ttcccaagag cctgtggctg tggtgccggg ctccagacac ttcacggaag gaagatcaca
1861 tgtccccaga gaggcacccc caggcaagct cgagggggcc acaccgtgtc ccagggagcc
1921 cagcctattc ccgttggctg gctgggcccc tctcagctgc tgggccccac ctccccactg
1981 cacccagggg gcaactccac ctggactgat gggcacagga ggcaccaata gcgattattg
2041 ggggcaatgc gaggtctcct cctatgccct tcctacccct gagtgggaca agaagggccc
2101 tgagtgccca ggagtgcccc acgttctgag aaggggccgg ccggagggag gggacccggc
2161 agggagattt cggttttgag gtttctaaat acattaaagt tatttcttaa gaaaaaaaaa
2221 aaaaaa
//