LOCUS BC051332 1998 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens coagulation factor II (thrombin), mRNA (cDNA clone
MGC:59803 IMAGE:6283420), complete cds.
ACCESSION BC051332
VERSION BC051332.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1998)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1998)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (25-APR-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: CGAP (Stanford)
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 47 Row: i Column: 22.
FEATURES Location/Qualifiers
source 1..1998
/db_xref="H-InvDB:HIT000053628"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:59803 IMAGE:6283420"
/tissue_type="Liver, hepatocellular carcinoma"
/clone_lib="NIH_MGC_100"
/lab_host="DH10B"
/note="Vector: pOTB7"
gene 1..1998
/gene="F2"
/gene_synonym="PT"
/db_xref="GeneID:2147"
/db_xref="HGNC:HGNC:3535"
/db_xref="MIM:176930"
CDS 12..1880
/gene="F2"
/gene_synonym="PT"
/codon_start=1
/product="coagulation factor II (thrombin)"
/protein_id="AAH51332.1"
/db_xref="GeneID:2147"
/db_xref="HGNC:HGNC:3535"
/db_xref="MIM:176930"
/translation="MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRA
NTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAA
CLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNP
DSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRG
QQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGAWCYV
AGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEA
DCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
ASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIH
PRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLK
ETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEG
DSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE"
BASE COUNT 461 a 536 c 620 g 381 t
ORIGIN
1 gctgacacac tatggcgcac gtccgaggct tgcagctgcc tggctgcctg gccctggctg
61 ccctgtgtag ccttgtgcac agccagcatg tgttcctggc tcctcagcaa gcacggtcgc
121 tgctccagcg ggtccggcga gccaacacct tcttggagga ggtgcgcaag ggcaacctgg
181 agcgagagtg cgtggaggag acgtgcagct acgaggaggc cttcgaggct ctggagtcct
241 ccacggctac ggatgtgttc tgggccaagt acacagcttg tgagacagcg aggacgcctc
301 gagataagct tgctgcatgt ctggaaggta actgtgctga gggtctgggt acgaactacc
361 gagggcatgt gaacatcacc cggtcaggca ttgagtgcca gctatggagg agtcgctacc
421 cacataagcc tgaaatcaac tccactaccc atcctggggc cgacctacag gagaatttct
481 gccgcaaccc cgacagcagc accacgggac cctggtgcta cactacagac cccaccgtga
541 ggaggcagga atgcagcatc cctgtctgtg gccaggatca agtcactgta gcgatgactc
601 cacgctccga aggctccagt gtgaatctgt cacctccatt ggagcagtgt gtccctgatc
661 gggggcagca gtaccagggg cgcctggcgg tgaccacaca tgggctcccc tgcctggcct
721 gggccagcgc acaggccaag gccctgagca agcaccagga cttcaactca gctgtgcagc
781 tggtggagaa cttctgccgc aacccagacg gggatgagga gggcgcgtgg tgctatgtgg
841 ccgggaagcc tggcgacttt gggtactgcg acctcaacta ttgtgaggag gccgtggagg
901 aggagacagg agatgggctg gatgaggact cagacagggc catcgaaggg cgtaccgcca
961 ccagtgagta ccagactttc ttcaatccga ggacctttgg ctcgggagag gcagactgtg
1021 ggctgcgacc tctgttcgag aagaagtcgc tggaggacaa aaccgaaaga gagctcctgg
1081 aatcctacat cgacgggcgc attgtggagg gctcggatgc agagatcggc atgtcacctt
1141 ggcaggtgat gcttttccgg aagagtcccc aggagctgct gtgtggggcc agcctcatca
1201 gtgaccgctg ggtcctcacc gccgcccact gcctcctgta cccgccctgg gacaagaact
1261 tcaccgagaa tgaccttctg gtgcgcattg gcaagcactc ccgcaccagg tacgagcgaa
1321 acattgaaaa gatatccatg ttggaaaaga tctacatcca ccccaggtac aactggcggg
1381 agaacctgga ccgggacatt gccctgatga agctgaagaa gcctgttgcc ttcagtgact
1441 acattcaccc tgtgtgtctg cccgacaggg agacggcagc cagcttgctc caggctggat
1501 acaaggggcg ggtgacaggc tggggcaacc tgaaggagac gtggacagcc aacgttggta
1561 aggggcagcc cagtgtcctg caggtggtga acctgcccat tgtggagcgg ccggtctgca
1621 aggactccac ccggatccgc atcactgaca acatgttctg tgctggttac aagcctgatg
1681 aagggaaacg aggggatgcc tgtgaaggtg acagtggggg accctttgtc atgaagagcc
1741 cctttaacaa ccgctggtat caaatgggca tcgtctcatg gggtgaaggc tgtgaccggg
1801 atgggaaata tggcttctac acacatgtgt tccgcctgaa gaagtggata cagaaggtca
1861 ttgatcagtt tggagagtag ggggccactc atattctggg ctcctggaac caatcccgtg
1921 aaagaattat ttttgtgttt ctaaaactat ggttcccaat aaaagtgact ctcagcgagc
1981 aaaaaaaaaa aaaaaaaa
//