LOCUS BC051321 1810 bp mRNA linear HUM 19-JUN-2006
DEFINITION Homo sapiens heparanase, mRNA (cDNA clone MGC:59678 IMAGE:6250265),
complete cds.
ACCESSION BC051321
VERSION BC051321.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1810)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1810)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (25-APR-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 47 Row: g Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 19923365.
FEATURES Location/Qualifiers
source 1..1810
/db_xref="H-InvDB:HIT000053622"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:59678 IMAGE:6250265"
/tissue_type="Pancreas, ductal carcinoma"
/clone_lib="NIH_MGC_110"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1810
/gene="HPSE"
/gene_synonym="HPA"
/gene_synonym="HPR1"
/gene_synonym="HPSE1"
/gene_synonym="HSE1"
/db_xref="GeneID:10855"
/db_xref="HGNC:HGNC:5164"
/db_xref="MIM:604724"
CDS 138..1769
/gene="HPSE"
/gene_synonym="HPA"
/gene_synonym="HPR1"
/gene_synonym="HPSE1"
/gene_synonym="HSE1"
/codon_start=1
/product="heparanase"
/protein_id="AAH51321.1"
/db_xref="GeneID:10855"
/db_xref="HGNC:HGNC:5164"
/db_xref="MIM:604724"
/translation="MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFF
TQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFL
IFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKF
KNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNI
SWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTA
KMLKSFLKAGGEVIDSVTWHHYYLNGRTATREDFLNPDVLDIFISSVQKVFQVVESTR
PGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYH
LVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDL
TLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTL
PPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI"
BASE COUNT 471 a 446 c 431 g 462 t
ORIGIN
1 ccagcgctgc tccccgggcg ctcctccccg ggcgctcctc cccaggcctc ccgggcgctt
61 ggatcccggc catctccgca cccttcaagt gggtgtgggt gatttcctgg cggggggagc
121 agccaggtga gcccaagatg ctgctgcgct cgaagcctgc gctgccgccg ccgctgatgc
181 tgctgctcct ggggccgctg ggtcccctct cccctggcgc cctgccccga cctgcgcaag
241 cacaggacgt cgtggacctg gacttcttca cccaggagcc gctgcacctg gtgagcccct
301 cgttcctgtc cgtcaccatt gacgccaacc tggccacgga cccgcggttc ctcatcctcc
361 tgggttctcc aaagcttcgt accttggcca gaggcttgtc tcctgcgtac ctgaggtttg
421 gtggcaccaa gacagacttc ctaattttcg atcccaagaa ggaatcaacc tttgaagaga
481 gaagttactg gcaatctcaa gtcaaccagg atatttgcaa atatggatcc atccctcctg
541 atgtggagga gaagttacgg ttggaatggc cctaccagga gcaattgcta ctccgagaac
601 actaccagaa aaagttcaag aacagcacct actcaagaag ctctgtagat gtgctataca
661 cttttgcaaa ctgctcagga ctggacttga tctttggcct aaatgcgtta ttaagaacag
721 cagatttgca gtggaacagt tctaatgctc agttgctcct ggactactgc tcttccaagg
781 ggtataacat ttcttgggaa ctaggcaatg aacctaacag tttccttaag aaggctgata
841 ttttcatcaa tgggtcgcag ttaggagaag attttattca attgcataaa cttctaagaa
901 agtccacctt caaaaatgca aaactctatg gtcctgatgt tggtcagcct cgaagaaaga
961 cggctaagat gctgaagagc ttcctgaagg ctggtggaga agtgattgat tcagttacat
1021 ggcatcacta ctatttgaat ggacggactg ctaccaggga agattttcta aaccctgatg
1081 tattggacat ttttatttca tctgtgcaaa aagttttcca ggtggttgag agcaccaggc
1141 ctggcaagaa ggtctggtta ggagaaacaa gctctgcata tggaggcgga gcgcccttgc
1201 tatccgacac ctttgcagct ggctttatgt ggctggataa attgggcctg tcagcccgaa
1261 tgggaataga agtggtgatg aggcaagtat tctttggagc aggaaactac catttagtgg
1321 atgaaaactt cgatccttta cctgattatt ggctatctct tctgttcaag aaattggtgg
1381 gcaccaaggt gttaatggca agcgtgcaag gttcaaagag aaggaagctt cgagtatacc
1441 ttcattgcac aaacactgac aatccaaggt ataaagaagg agatttaact ctgtatgcca
1501 taaacctcca taatgtcacc aagtacttgc ggttacccta tcctttttct aacaagcaag
1561 tggataaata ccttctaaga cctttgggac ctcatggatt actttccaaa tctgtccaac
1621 tcaatggtct aactctaaag atggtggatg atcaaacctt gccaccttta atggaaaaac
1681 ctctccggcc aggaagttca ctgggcttgc cagctttctc atatagtttt tttgtgataa
1741 gaaatgccaa agttgctgct tgcatctgaa aataaaatat actagtcctg acaaaaaaaa
1801 aaaaaaaaaa
//