LOCUS BC047871 2924 bp mRNA linear HUM 04-NOV-2003
DEFINITION Homo sapiens CDC42 binding protein kinase beta (DMPK-like), mRNA
(cDNA clone IMAGE:6196582), partial cds.
ACCESSION BC047871
VERSION BC047871.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2924)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2924)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (03-MAR-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Dr. James R. Lupski
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 107 Row: o Column: 15
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 16357473.
FEATURES Location/Qualifiers
source 1..2924
/db_xref="H-InvDB:HIT000098806"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:6196582"
/tissue_type="Peripheral Nervous System, sympathetic
trunk"
/clone_lib="Lupski_sympathetic_trunk"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..>2924
/gene="CDC42BPB"
/gene_synonym="KIAA1124"
/gene_synonym="MRCKB"
/db_xref="GeneID:9578"
CDS 126..>2924
/gene="CDC42BPB"
/gene_synonym="KIAA1124"
/gene_synonym="MRCKB"
/codon_start=1
/product="CDC42BPB protein"
/protein_id="AAH47871.1"
/db_xref="GeneID:9578"
/translation="MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHS
ALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIY
AMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGD
LLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLAD
FGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLY
GETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIE
DFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFS
GLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRL
EQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLE
RQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQAKELKDA
HQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEK
LRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQE
ISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKL
EKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLE
DELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALRSSSLGS
RTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDS
EAKNRELLEEMEILKKKKK"
misc_feature 351..1151
/gene="CDC42BPB"
/gene_synonym="KIAA1124"
/gene_synonym="MRCKB"
/note="S_TKc; Region: Serine/Threonine protein kinases,
catalytic domain"
/db_xref="CDD:smart00220"
misc_feature 1407..2825
/gene="CDC42BPB"
/gene_synonym="KIAA1124"
/gene_synonym="MRCKB"
/note="Myosin_tail; Region: Myosin tail. The myosin
molecule is a multi-subunit complex made up of two heavy
chains and four light chains it is a fundamental
contractile protein found in all eukaryote cell types.
This family consists of the coiled-coil myosin heavy chain
tail region. The coiled-coil is composed of the tail from
two molecules of myosin. These can then assemble into the
macromolecular thick filament. The coiled-coil region
provides the structural backbone the thick filament"
/db_xref="CDD:pfam01576"
BASE COUNT 826 a 661 c 883 g 554 t
ORIGIN
1 gcggcgagga ggcgccgctg ctgctgccgg ggctcgcagc cgccgagccc ccgagggcgc
61 gccctgacgg actggccgag ccggcggtga gaggccggcg cgtcgggagc gggccgcgcg
121 gcaccatgtc ggccaaggtg cggctcaaga agctggagca gctgctcctg gacgggccct
181 ggcgcaacga gagcgccctg agcgtggaaa cgctgctcga cgtgctcgtc tgcctgtaca
241 ccgagtgcag ccactcggcc ctgcgccgcg acaagtacgt ggccgagttc ctcgagtggg
301 ctaaaccatt tacacagctg gtgaaagaaa tgcagcttca tcgagaagac tttgaaataa
361 ttaaagtaat tggaagaggt gcttttggtg aggttgctgt tgtcaaaatg aagaatactg
421 aacgaattta tgcaatgaaa atcctcaaca agtgggagat gctgaaaaga gcagagaccg
481 cgtgcttccg agaggagcgc gatgtgctgg tgaacggcga ctgccagtgg atcaccgcgc
541 tgcactacgc ctttcaggac gagaaccacc tgtacttagt catggattac tatgtgggtg
601 gtgatttact gaccctgctc agcaaatttg aagacaagct tccggaagat atggcgaggt
661 tctacattgg tgaaatggtg ctggccattg actccatcca tcagcttcat tacgtgcaca
721 gagacattaa acctgacaat gtccttttgg acgtgaatgg tcatatccgc ctggctgact
781 ttggatcatg tttgaagatg aatgatgatg gcactgtgca gtcctccgtg gccgtgggca
841 cacctgacta catctcgccg gagatcctgc aggcgatgga ggacggcatg ggcaaatacg
901 ggcctgagtg tgactggtgg tctctgggtg tctgcatgta tgagatgctc tatggagaaa
961 cgccgtttta tgcggagtca ctcgtggaga cctatgggaa gatcatgaac catgaagagc
1021 gattccagtt cccatcccat gtcacggatg tatctgaaga agcgaaggac ctcatccaga
1081 gactgatctg cagtagagaa cgccggctgg ggcagaatgg aatagaggat ttcaaaaagc
1141 atgcgttttt tgaaggtcta aattgggaaa atatacgaaa cctagaagca ccttatattc
1201 ctgatgtgag cagtccctct gacacatcca acttcgacgt ggatgacgac gtgctgagaa
1261 acacggaaat attacctcct ggttctcaca caggcttttc tggattacat ttgccattca
1321 ttggttttac attcacaacg gaaagctgtt tttctgatcg aggctctctg aagagcataa
1381 tgcagtccaa cacattaacc aaagatgagg atgtgcagcg ggacctggag cacagcctgc
1441 agatggaagc ttacgagagg aggattcgga ggctggaaca ggagaagctg gagctgagca
1501 ggaagctgca agagtccacc cagaccgtgc agtccctcca cggctcatct cgggccctca
1561 gcaattcaaa ccgagataaa gaaatcaaaa agctaaatga agaaatcgaa cgcttgaaga
1621 ataaaatagc agattcaaac aggctggagc gacagcttga ggacacagtg gcgcttcgcc
1681 aagagcgtga ggactccacg cagcggctgc gggggctgga gaagcagcac cgcgtggtcc
1741 ggcaggagaa ggaggagctg cacaagcaac tggttgaagc ctcagagcgg ttgaaatccc
1801 aggccaagga actcaaagat gcccatcagc agcgaaagct ggccctgcag gagttctcgg
1861 agctgaacga gcgcatggca gagctccgtg cccagaagca gaaggtgtcc cggcagctgc
1921 gagacaagga ggaggagatg gaggtggcca cgcagaaggt ggacgccatg cggcaggaaa
1981 tgcggagagc tgagaagctc aggaaagagc tggaagctca gcttgatgat gctgttgctg
2041 aggcctccaa ggagcgcaag cttcgtgagc acagcgagaa cttctgcaag caaatggaaa
2101 gcgagctgga ggccctcaag gtgaagcaag gaggccgggg agcgggtgcc accttagagc
2161 accagcaaga gatttccaaa atcaaatccg agctggagaa gaaagtctta ttttatgaag
2221 aggaattggt cagacgtgag gcctcccatg tgctagaagt gaaaaatgtg aagaaggagg
2281 tgcatgattc agaaagccac cagctggccc tgcagaaaga aatcttgatg ttaaaagata
2341 agttagaaaa gtcaaagcga gaacggcata acgagatgga ggaggcagta ggtacaataa
2401 aagataaata cgaacgagaa agagcgatgc tgtttgatga aaacaagaag ctaactgctg
2461 aaaatgaaaa gctctgttcc tttgtggata aactcacagc tcaaaataga cagctggagg
2521 atgagctgca ggatctggca gccaagaagg agtcagtggc ccactgggaa gctcagattg
2581 cggaaatcat tcagtgggtc agtgacgaga aagatgcccg gggttacctt caagctcttg
2641 cttccaagat gaccgaagag ctcgaggctt tgaggagttc tagtctgggg tcaagaacac
2701 tggacccgct gtggaaggtg cgccgcagcc agaagctgga catgtccgcg cggctggagc
2761 tgcagtcggc cctggaggcg gagatccggg ccaagcagct tgtccaggag gagctcagga
2821 aggtcaagga cgccaacctc accttggaaa gcaaactaaa ggattccgaa gccaaaaaca
2881 gagaattatt agaagaaatg gaaattttga aaaaaaaaaa aaaa
//