LOCUS BC046242 3925 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens adaptor-related protein complex 1, beta 1 subunit,
mRNA (cDNA clone MGC:52262 IMAGE:5929327), complete cds.
ACCESSION BC046242
VERSION BC046242.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3925)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3925)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (31-JAN-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Lou Staudt
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 44 Row: p Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 22027650.
FEATURES Location/Qualifiers
source 1..3925
/db_xref="H-InvDB:HIT000053023"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:52262 IMAGE:5929327"
/tissue_type="Lymph, lymphoma"
/clone_lib="NIH_MGC_99"
/lab_host="DH10B"
/note="Vector: pOTB7"
gene 1..3925
/gene="AP1B1"
/gene_synonym="ADTB1"
/gene_synonym="AP105A"
/gene_synonym="BAM22"
/gene_synonym="CLAPB2"
/db_xref="GeneID:162"
/db_xref="MIM:600157"
CDS 188..2947
/gene="AP1B1"
/gene_synonym="ADTB1"
/gene_synonym="AP105A"
/gene_synonym="BAM22"
/gene_synonym="CLAPB2"
/codon_start=1
/product="AP1B1 protein"
/protein_id="AAH46242.1"
/db_xref="GeneID:162"
/db_xref="MIM:600157"
/translation="MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVG
KDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLI
RALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQG
FLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWG
QIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDY
YGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYV
KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV
STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIW
IVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLS
LATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICY
IGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVIPA
QGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLIGGTNFVAPPTAAVPA
NLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVGSISMDLQLTNKALQVMTDFAIQFN
RNSFGLAPAAPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYF
STLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIF
TVAKRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSCTLSLKCRAPEVSQHVYQAYE
TILKN"
misc_feature 236..1789
/gene="AP1B1"
/gene_synonym="ADTB1"
/gene_synonym="AP105A"
/gene_synonym="BAM22"
/gene_synonym="CLAPB2"
/note="Adaptin_N; Region: Adaptin N terminal region. This
family consists of the N terminal region of various alpha,
beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor
protein complexes. The adaptor protein (AP) complexes are
involved in the formation of clathrin-coated pits and
vesicles. The N-terminal region of the various adaptor
proteins (APs) is constant by comparison to the C-terminal
which is variable within members of the AP-2 family"
/db_xref="CDD:pfam01602"
misc_feature 2333..2584
/gene="AP1B1"
/gene_synonym="ADTB1"
/gene_synonym="AP105A"
/gene_synonym="BAM22"
/gene_synonym="CLAPB2"
/note="Alpha_adaptinC2; Region: pfam02883,
Alpha_adaptinC2, Adaptin C-terminal domain. Alpha adaptin
is a heterotetramer which regulates clathrin-bud
formation. The carboxyl-terminal appendage of the alpha
subunit regulates translocation of endocytic accessory
proteins to the bud site. This ig-fold domain is found in
alpha, beta and gamma adaptins"
/db_xref="CDD:pfam02883"
BASE COUNT 857 a 1206 c 1143 g 719 t
ORIGIN
1 cccgcgcgcg ggcagctcac ttccgcccgg caggtgacag ccgcggggct ccgagccgcc
61 ggcagcccgg acgcaccggg agagcgagag gtggaggccg cggacatttt ggtgccaagc
121 cgaaccgagc cggggcgccg ggagctattg ggacctgcgg aagcctggct acagataagg
181 gaccaaaatg actgactcaa aatatttcac cacgaccaag aaaggggaga tcttcgagct
241 gaaggcagag ctcaacagtg acaagaagga gaagaagaag gaggcagtga agaaagtgat
301 tgcatcgatg accgtgggca aagatgtcag tgccctcttc cccgatgtgg tcaactgcat
361 gcagacggac aacctggagc tgaagaagct ggtatacctc tacttgatga attacgccaa
421 gagtcagcct gacatggcca ttatggccgt caacaccttt gtgaaggact gtgaggaccc
481 caaccccctc atccgagccc tggcagtgcg gaccatgggc tgcatccgcg ttgacaagat
541 cacagagtac ctgtgcgagc cactccggaa gtgcctgaag gacgaggatc catatgtgcg
601 caagacagca gctgtgtgcg tggccaagct ccacgacatc aacgcccagc tggtggagga
661 ccagggcttc ctggacaccc ttaaagacct catctccgac tctaacccca tggtggtggc
721 caatgcagtg gcagcgctct cagaaattgc cgagtctcac cccagcagca acctgctcga
781 tctgaaccca cagtccatca acaagctgct gacagccctc aatgagtgca ccgagtgggg
841 ccagatcttc atcctggact gcctcgccaa ctatatgccc aaggacgacc gcgaggccca
901 gagcatctgt gagcgggtca cccccaggct ctcccatgcc aactccgctg tggtgctctc
961 tgctgtgaag gtgctgatga agttcatgga gatgttgtct aaggacttgg actactacgg
1021 cacactgctc aagaagctgg ccccacccct ggtcacactg ctgtcagccg agccagagct
1081 gcagtatgtg gccctgcgca acatcaatct catcgtgcag aaaaggcctg agatcctgaa
1141 gcatgagatg aaggtgttct tcgtgaagta caacgaccct atctacgtga agctggagaa
1201 gctggacatc atgatccgcc tggcctctca ggccaacatc gcccaggtgt tggcagagct
1261 gaaagagtac gcaacagaag tggatgtgga ctttgtacgg aaggctgtgc gtgctattgg
1321 ccgctgcgcc atcaaggtgg agcaatctgc ggagcgctgt gtgagcacgc tgctcgacct
1381 catccagacc aaggtcaact atgtggtcca ggaggccatc gtggtcatca aggacatctt
1441 ccgcaagtac cccaacaagt atgagagtgt gattgccaca ctgtgtgaga atctggactc
1501 cctggatgag cctgaggccc gggctgccat gatctggatt gtgggcgagt acgcggaacg
1561 gatcgacaac gcagatgagc tgctggagag cttcctcgag ggcttccatg acgagagcac
1621 acaggtccag ctgcagctgc tgacagccat tgtgaaactc tttctaaaga agccaacaga
1681 gacccaggag ctggtgcagc aggtcctcag tttggccact caggactcag ataacccaga
1741 cctgcgggac cgtggctaca tctactggcg cctgctgtcc acggacccgg tggcagccaa
1801 ggaggtggtg ttggctgaga agccactcat ctctgaagag acggacctca tcgagcccac
1861 actgttagac gagcttatct gctacatcgg cacgctggct tccgtctacc ataagcctcc
1921 cagtgccttt gtggaggggg gccggggcgt cgtgcacaag agcctgccac ctcgcacggc
1981 ctcgagtgag agcgcagaga gccctgagac agcccctact ggagcacctc ctggggagca
2041 gccagatgtc atccccgccc agggcgacct gctgggtgac ctcctcaacc tggacctcgg
2101 ccccccagtg agcggcccac ccctggccac ctcctcggtg cagatgggag ctgtggacct
2161 tcttggcggt ggccttgaca gcctgattgg gggcaccaac ttcgtggcac ctccaacagc
2221 agcagtacca gccaatcttg gagcacccat cggcagtggc ctgagtgacc tctttgacct
2281 gaccagtggc gtgggcaccc tgtcaggatc atatgtggcc cccaaagcag tgggctccat
2341 ctccatggac ctgcagctga ccaacaaggc cttgcaggtc atgaccgact ttgccatcca
2401 gttcaaccgc aacagctttg gcctggcccc cgccgccccc ctccaggtcc acgcaccact
2461 cagccccaac cagacagtgg agatctccct gcctctcagc acggtgggct cggtcatgaa
2521 gatggagcct ctgaacaacc tccaggtggc cgtgaagaac aacatcgatg tcttctactt
2581 cagcaccttg tacccactgc acatcctctt tgtggaggac gggaagatgg accggcagat
2641 gttcctggcc acatggaagg atattcccaa tgagaatgag gcccagttcc agatcagaga
2701 ctgccccctc aatgcagagg ctgcgagcag caagctgcag agcagcaaca tcttcactgt
2761 cgccaagagg aacgtggagg gccaggacat gctctaccag tccctgaagc tgaccaacgg
2821 catctgggtg ctggcggagc tgcggatcca gccgggcaac cccagctgca cgctgtccct
2881 gaagtgtcga gcaccagagg tgtcccagca cgtgtaccag gcctacgaga ccatcctcaa
2941 gaactgagac cccggccagc gcccacccca gccttctgcc cgccccatcg aggaggcccc
3001 tcgggggcag cacatcttcc tcctcgcagg agggaccagg cggggctcca ggccactcag
3061 tgggctccct ggtcctgatg gcagaaccca cccgatccct ggggtagggc accaccccct
3121 cctggggtga gagcgcagtg cactcccgtg ctctgggaca cccctgctcc tgtggctgtg
3181 atgtggggtt aagtgaggtg gggaccaaag gaaacagagc cagagcagcc acagaagctg
3241 tgcctgaagg gtgagtgtgg agcttgcccc tccggctcac agccccggca gcccctggct
3301 ccttggtctc tccggttggt gttaaagggc cctccactgc cacctctcat gggatggacc
3361 ctgccaacct ggcctgggtg tgcagggagg ggttcccctt ggtaccagga gagctgctca
3421 cttagggcct ggggctcaag gagctgtagg tgccggcaga ggggcagagc taggctggga
3481 ggagcccagg gcctgcacca cccacttgca accaccaggc tggtgccctg cagctgtgcc
3541 agttgggcca cagcctcccg agtgctgacc cacatggtca agaccaggca gaagctccca
3601 gagcccctgt ctcgggctcc ccaccgactg gcagctgcac tatccccaac tccccacttc
3661 tgccccaagg gtggtcactg cctgtgatac attcctcagt gtcgcctctg agcccaggcc
3721 tcctgccaca aagactgggc cgagagatgg ggctgggtaa gcgggtgcgc ctcctgtttg
3781 ggtttcttcg gggtttctct gtagtgtctg ctgccctcct cctggcctcc caggtttcag
3841 ttgtgtctga cagagcatta ggttttcctg ttactgctgt gtaataataa agaaagattc
3901 ggcaaaaaaa aaaaaaaaaa aaaaa
//