LOCUS BC046160 1529 bp mRNA linear HUM 07-OCT-2003 DEFINITION Homo sapiens paraoxonase 2, mRNA (cDNA clone MGC:57708 IMAGE:5393700), complete cds. ACCESSION BC046160 VERSION BC046160.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1529) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1529) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (31-JAN-2003) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: DCTD/DTP cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Sequencing Group at the Stanford Human Genome Center, Stanford University School of Medicine, Stanford, CA 94305 Web site: http://www-shgc.stanford.edu Contact: (Dickson, Mark) mcd@paxil.stanford.edu Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers, R. M. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 107 Row: e Column: 18 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 4505952. FEATURES Location/Qualifiers source 1..1529 /db_xref="H-InvDB:HIT000053007" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:57708 IMAGE:5393700" /tissue_type="Breast, mammary adenocarcinoma." /clone_lib="NIH_MGC_87" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..1529 /gene="PON2" /db_xref="GeneID:5445" /db_xref="MIM:602447" CDS 41..700 /gene="PON2" /codon_start=1 /product="PON2 protein" /protein_id="AAH46160.1" /db_xref="GeneID:5445" /db_xref="MIM:602447" /translation="MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHL IKGIEAGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRI SRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEGENSLLHLKTVKH ELLPSVNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVYLC C" misc_feature 125..685 /gene="PON2" /note="Arylesterase; Region: Arylesterase. This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyses organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation" /db_xref="CDD:pfam01731" BASE COUNT 463 a 307 c 323 g 436 t ORIGIN 1 ggccaggccg gagcgaggca gcgcgcccgg ctcccgcgcc atggggcggc tggtggctgt 61 gggcttgctg gggatcgcgc tggcgctcct gggcgagagg cttctggcac tcagaaatcg 121 acttaaagcc tccagagaag tagaatctgt agaccttcca cactgccacc tgattaaagg 181 aattgaagct ggctctgaag atattgacat acttcccaat ggtctggctt tttttagtgt 241 gggtctaaaa ttcccaggac tccacagctt tgcaccagat aagcctggag gaatactaat 301 gatggatcta aaagaagaaa aaccaagggc acgggaatta agaatcagtc gtgggtttga 361 tttggcctca ttcaatccac atggcatcag cactttcata gacaacgatg acacagttta 421 tctctttgtt gtaaaccacc cagaattcaa gaatacagtg gaaattttta aatttgaaga 481 aggagaaaat tctctgttgc atctgaaaac agtcaaacat gagcttcttc caagtgtgaa 541 tgacatcaca gctgttggac cggcacattt ctatgccaca aatgaccact acttctctga 601 tcctttctta aagtatttag aaacatactt gaacttacac tgggcaaatg ttgtttacta 661 cagtccaaat gaagttaaag tggtatatct atgttgctga catattggct catgaaattc 721 atgttttgga aaaacacact aatatgaatt taactcagtt gaaggtactt gagctggata 781 cactggtgga taatttatct attgatcctt cctcggggga catctgggta ggctgtcatc 841 ctaatggcca gaagctcttc gtgtatgacc cgaacaatcc tccctcgtca gaggttctcc 901 gcatccagaa cattctatgt gagaagccta cagtgactac agtttatgcc aacaatgggt 961 ctgttctcca aggaagttct gtagcctcag tgtatgatgg gaagctgctc ataggcactt 1021 tataccacag agccttgtat tgtgaactct aaattgtact tttggcatga aagtgcgata 1081 acttaacaat taattttcta tgaattgcta attctgaggg aatttaacca gcaacattga 1141 cccagaaatg tatggcatgt gtagttaatt ttattccagt aaggaacggc ccttttagtt 1201 cttagagcac ttttaacaaa aaaggaaaat gaacaggttc tttaaaatgc caagcaaggg 1261 acagaaaaga aagctgcttt cgaataaagt gaatacattt tgcacaaagt aagcctcacc 1321 tttgccttcc aactgccaga acatggattc cactgaaata gagtgaatta tatttcctta 1381 aaatgtgagt gacctcactt ctggcactgt gactactatg gctgtttaga actactgata 1441 ataacgtatt ttgatgtttt gtacttacat ctttgtttac cattaaaaag ttggagttat 1501 attaaagact aactaaaaaa aaaaaaaaa //