LOCUS       BC046160                1529 bp    mRNA    linear   HUM 07-OCT-2003
DEFINITION  Homo sapiens paraoxonase 2, mRNA (cDNA clone MGC:57708
            IMAGE:5393700), complete cds.
ACCESSION   BC046160
VERSION     BC046160.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1529)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 1529)
  AUTHORS   Strausberg,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JAN-2003) National Institutes of Health, Mammalian
            Gene Collection (MGC), Cancer Genomics Office, National Cancer
            Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
            USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: DCTD/DTP
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 107 Row: e Column: 18
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 4505952.
FEATURES             Location/Qualifiers
     source          1..1529
                     /db_xref="H-InvDB:HIT000053007"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:57708 IMAGE:5393700"
                     /tissue_type="Breast, mammary adenocarcinoma."
                     /clone_lib="NIH_MGC_87"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..1529
                     /gene="PON2"
                     /db_xref="GeneID:5445"
                     /db_xref="MIM:602447"
     CDS             41..700
                     /gene="PON2"
                     /codon_start=1
                     /product="PON2 protein"
                     /protein_id="AAH46160.1"
                     /db_xref="GeneID:5445"
                     /db_xref="MIM:602447"
                     /translation="MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHL
                     IKGIEAGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRI
                     SRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEGENSLLHLKTVKH
                     ELLPSVNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVYLC
                     C"
     misc_feature    125..685
                     /gene="PON2"
                     /note="Arylesterase; Region: Arylesterase. This family
                     consists of arylesterases (Also known as serum
                     paraoxonase) EC:3.1.1.2. These enzymes hydrolyses
                     organophosphorus esters such as paraoxon and are found in
                     the liver and blood. They confer resistance to
                     organophosphate toxicity. Human arylesterase (PON1) is
                     associated with HDL and may protect against LDL oxidation"
                     /db_xref="CDD:pfam01731"
BASE COUNT          463 a          307 c          323 g          436 t
ORIGIN      
        1 ggccaggccg gagcgaggca gcgcgcccgg ctcccgcgcc atggggcggc tggtggctgt
       61 gggcttgctg gggatcgcgc tggcgctcct gggcgagagg cttctggcac tcagaaatcg
      121 acttaaagcc tccagagaag tagaatctgt agaccttcca cactgccacc tgattaaagg
      181 aattgaagct ggctctgaag atattgacat acttcccaat ggtctggctt tttttagtgt
      241 gggtctaaaa ttcccaggac tccacagctt tgcaccagat aagcctggag gaatactaat
      301 gatggatcta aaagaagaaa aaccaagggc acgggaatta agaatcagtc gtgggtttga
      361 tttggcctca ttcaatccac atggcatcag cactttcata gacaacgatg acacagttta
      421 tctctttgtt gtaaaccacc cagaattcaa gaatacagtg gaaattttta aatttgaaga
      481 aggagaaaat tctctgttgc atctgaaaac agtcaaacat gagcttcttc caagtgtgaa
      541 tgacatcaca gctgttggac cggcacattt ctatgccaca aatgaccact acttctctga
      601 tcctttctta aagtatttag aaacatactt gaacttacac tgggcaaatg ttgtttacta
      661 cagtccaaat gaagttaaag tggtatatct atgttgctga catattggct catgaaattc
      721 atgttttgga aaaacacact aatatgaatt taactcagtt gaaggtactt gagctggata
      781 cactggtgga taatttatct attgatcctt cctcggggga catctgggta ggctgtcatc
      841 ctaatggcca gaagctcttc gtgtatgacc cgaacaatcc tccctcgtca gaggttctcc
      901 gcatccagaa cattctatgt gagaagccta cagtgactac agtttatgcc aacaatgggt
      961 ctgttctcca aggaagttct gtagcctcag tgtatgatgg gaagctgctc ataggcactt
     1021 tataccacag agccttgtat tgtgaactct aaattgtact tttggcatga aagtgcgata
     1081 acttaacaat taattttcta tgaattgcta attctgaggg aatttaacca gcaacattga
     1141 cccagaaatg tatggcatgt gtagttaatt ttattccagt aaggaacggc ccttttagtt
     1201 cttagagcac ttttaacaaa aaaggaaaat gaacaggttc tttaaaatgc caagcaaggg
     1261 acagaaaaga aagctgcttt cgaataaagt gaatacattt tgcacaaagt aagcctcacc
     1321 tttgccttcc aactgccaga acatggattc cactgaaata gagtgaatta tatttcctta
     1381 aaatgtgagt gacctcactt ctggcactgt gactactatg gctgtttaga actactgata
     1441 ataacgtatt ttgatgtttt gtacttacat ctttgtttac cattaaaaag ttggagttat
     1501 attaaagact aactaaaaaa aaaaaaaaa
//