LOCUS BC044656 4129 bp mRNA linear HUM 19-JUN-2006
DEFINITION Homo sapiens cancer susceptibility candidate 3, mRNA (cDNA clone
MGC:47538 IMAGE:5547561), complete cds.
ACCESSION BC044656
VERSION BC044656.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4129)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4129)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (17-JAN-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 82 Row: g Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 24475733.
FEATURES Location/Qualifiers
source 1..4129
/db_xref="H-InvDB:HIT000052888"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:47538 IMAGE:5547561"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_72"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..4129
/gene="CASC3"
/gene_synonym="BTZ"
/gene_synonym="MLN51"
/db_xref="GeneID:22794"
/db_xref="HGNC:HGNC:17040"
/db_xref="MIM:606504"
CDS 179..2290
/gene="CASC3"
/gene_synonym="BTZ"
/gene_synonym="MLN51"
/codon_start=1
/product="cancer susceptibility candidate 3"
/protein_id="AAH44656.1"
/db_xref="GeneID:22794"
/db_xref="HGNC:HGNC:17040"
/db_xref="MIM:606504"
/translation="MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGG
SGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEE
GEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVEN
KVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRW
EHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGE
RLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQ
HGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAP
PPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGT
WEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNR
MEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAP
LPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSA
PGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPR
RTPQPVTIKPPPPEVVSRGSS"
BASE COUNT 1065 a 1064 c 1028 g 972 t
ORIGIN
1 cacacacaca ccccaacaca cacacacaca cacacacaca cacacacaca cacacacaca
61 gcgggatggc cgagcgccgc acgcgtagca cgccgggact agctatccag cctcccagca
121 gcctctgcga cgggcgcggt gcgtaagtac ctcgccggtg gtggccgttc tccgtaagat
181 ggcggaccgg cggcggcagc gcgcttcgca agacaccgag gacgaggaat ctggtgcttc
241 gggctccgac agcggcggct ccccgttgcg gggaggcggg agctgcagcg gtagcgccgg
301 aggcggcggc agcggctctc tgccttcaca gcgcggaggc cgaaccgggg cccttcatct
361 gcggcgggtg gagagcgggg gcgccaagag tgctgaggag tcggagtgtg agagtgaaga
421 tggcattgaa ggtgatgctg ttctctcgga ttatgaaagt gcagaagact cggaaggtga
481 agaaggtgaa tacagtgaag aggaaaactc caaagtggag ctgaaatcag aagctaatga
541 tgctgttaat tcttcaacaa aagaagagaa gggagaagaa aagcctgaca ccaaaagcac
601 tgtgactgga gagaggcaaa gtggggacgg acaggagagc acagagcctg tggagaacaa
661 agtgggtaaa aagggcccta agcatttgga tgatgatgaa gatcggaaga atccagcata
721 catacctcgg aaagggctct tctttgagca tgatcttcga gggcaaactc aggaggagga
781 agtcagaccc aaggggcgtc agcgaaagct atggaaggat gagggtcgct gggagcatga
841 caagttccgg gaagatgagc aggccccaaa gtcccgacag gagctcattg ctctttatgg
901 ttatgacatt cgctcagctc ataatcctga tgacatcaaa cctcgaagaa tccggaaacc
961 ccgatatggg agtcctccac aaagagatcc aaactggaac ggtgagcggc taaacaagtc
1021 tcatcgccac cagggtcttg ggggcaccct accaccaagg acatttatta acaggaatgc
1081 tgcaggtacc ggccgtatgt ctgcacccag gaattattct cgatctgggg gcttcaagga
1141 aggtcgtgct ggttttaggc ctgtggaagc tggtgggcag catggtggcc ggtctggtga
1201 gactgttaag catgagatta gttaccggtc acggcgccta gagcagactt ctgtgaggga
1261 tccatctcca gaagcagatg ctccagtgct tggcagtcct gagaaggaag aggcagcctc
1321 agagccacca gctgctgctc ctgatgctgc accaccaccc cctgataggc ccattgagaa
1381 gaaatcctat tcccgggcaa gaagaactcg aaccaaagtt ggagatgcag tcaagcttgc
1441 agaggaggtg ccccctcctc ctgaaggact gattccagca cctccagtcc cagaaaccac
1501 cccaactcca cctactaaga ctgggacctg ggaagctccg gtggattcta gtacaagtgg
1561 acttgagcaa gatgtggcac aactaaatat agcagaacag aattggagtc cggggcagcc
1621 ttctttcctg caaccacggg aacttcgagg tatgcccaac catatacaca tgggagcagg
1681 acctccacct cagtttaacc ggatggaaga aatgggtgtc cagggtggtc gagccaaacg
1741 ctattcatcc cagcggcaaa gacctgtgcc agagcccccc gcccctccag tgcatatcag
1801 tatcatggag ggacattact atgatccact gcagttccag ggaccaatct atacccatgg
1861 tgacagccct gccccgctgc ctccacaggg catgcttgtg cagccaggaa tgaaccttcc
1921 ccacccaggt ttacatcccc accagacacc agctcctctg cccaatccag gcctctatcc
1981 cccaccagtg tccatgtctc caggacagcc accacctcag cagttgcttg ctcctactta
2041 cttttctgct ccaggcgtca tgaactttgg taatcccagt tacccttatg ctccaggggc
2101 actgcctccc ccaccaccgc ctcatctgta tcctaataca caggccccat cacaggtata
2161 tggaggagtg acctactata accccgccca gcagcaggtg cagccaaagc cctccccacc
2221 ccggaggact ccccagccag tcaccatcaa gccccctcca cctgaggttg taagcagggg
2281 ttccagttaa tacaagtttc tgaatatttt aaatcttaac atcatataaa aagcagcaga
2341 ggtgagaact cagaagagaa atacagctgg ctatctacta ccagaagggc ttcaaagata
2401 tagggtgtgg ctcctaccag caaacagctg aaagaggagg acccctgcct tcctctgagg
2461 acaggctcta gagagaggga gaaacaagtg gacctcgtcc catcttcact cttcacttga
2521 gttggctgtg ttcgggggag cagagagagc cagacagccc caagcttctg agtctagata
2581 cagaagccca tgtcttctgc tgttcttcac ttctgggaaa ttgaagtgtc ttctgttccc
2641 aaggaagctc cttcctgttt gttttgtttt ctaagatgtt catttttaaa gcctggcttc
2701 ttatccttaa tattatttta attttttctc tttgtttctg tttcttgctc tctctccctg
2761 cctttaaatg aaacaagtct agtcttctgg ttttctagcc cctctggatt cccttttgac
2821 tcttccgtgc atcccagata atggagaatg tatcagccag ccttccccac caagtctaaa
2881 aagacctggc ctttcacttt tagttggcat ttgttatcct cttgtatact tgtattccct
2941 taactctaac cctgtggaag catggctgtc tgcacagagg gtcccattgt gcagaaaagc
3001 tcagagtagg tgggtaggag cccttctctt tgacttaggt ttttaggagt ctgagcatcc
3061 atcaatacct gtactatgat gggcttctgt tctctgctga gggccaatac cctactgtgg
3121 ggagagatgg cacaccagat gcttttgtga gaaagggatg gtggagtgag agcctttgcc
3181 tttaggggtg tgtattcaca tagtcctcag ggctcagtct tttgaggtaa gtggaattag
3241 agggccttgc ttctcttctt tccattcttc ttgctacacc ccttttccag ttgctgtgga
3301 ccaatgcatc tctttaaagg caaatattat ccagcaagca gtctaccctg tcctttgcaa
3361 ttgctcttct ccacgtcttt cctgctacaa gtgttttaga tgttactacc ttattttccc
3421 cgaattctat ttttgtcctt gcagacagaa tataaaaact cctgggctta aggcctaagg
3481 aagccagtca ccttctgggc aagggctcct atctttcctc cctatccatg gcactaaacc
3541 acttctctgc tgcctctgtg gaagagattc ctattactgc agtacatacg tctgccaggg
3601 gtaacctggc cactgtccct gtccttctac agaacctgag ggcaaagatg gtggctgtgt
3661 ctctccccgg taatgtcact gtttttattc cttccatcta gcagctggcc taatcactct
3721 gagtcacagg tgtgggatgg agagtgggga gaggcactta atctgtaacc cccaaggagg
3781 aaataactaa gagattcttc taggggtagc tggtggttgt gccttttgta ggctgttccc
3841 tttgccttaa acctgaagat gtctcctcaa gcctgtgggc agcatgccca gattcccaga
3901 ccttaagaca ctgtgagagt tgtctctgtt ggtccactgt gtttagttgc aaggattttt
3961 ccatgtgtgg tggtgttttt tgttactgtt ttaaagggtg cccatttgtg atcagcattg
4021 tgacttggag ataataaaat ttagactata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
4081 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//