LOCUS BC043247 3733 bp mRNA linear HUM 06-OCT-2003
DEFINITION Homo sapiens transducin-like enhancer of split 3 (E(sp1) homolog,
Drosophila), mRNA (cDNA clone MGC:44362 IMAGE:5296274), complete
cds.
ACCESSION BC043247
VERSION BC043247.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3733)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3733)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (09-JAN-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Sep 16, 2003 this sequence version replaced BC043247.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 76 Row: l Column: 23.
FEATURES Location/Qualifiers
source 1..3733
/db_xref="H-InvDB:HIT000097568"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:44362 IMAGE:5296274"
/tissue_type="Testis"
/clone_lib="NIH_MGC_97"
/lab_host="DH10B"
/note="Vector: pBluescript"
gene 1..3733
/gene="TLE3"
/gene_synonym="ESG"
/gene_synonym="ESG3"
/gene_synonym="KIAA1547"
/db_xref="GeneID:7090"
/db_xref="MIM:600190"
CDS 1119..3422
/gene="TLE3"
/gene_synonym="ESG"
/gene_synonym="ESG3"
/gene_synonym="KIAA1547"
/codon_start=1
/product="TLE3 protein"
/protein_id="AAH43247.1"
/db_xref="GeneID:7090"
/db_xref="MIM:600190"
/translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
GSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSA
DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
RSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
PGLRSMPGKPPGMDPIGIMASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGL
HNIPPQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSAD
GQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWD
ISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAE
LTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHD
GTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH
HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVL
SCDISADDKYIVTGSGDKKATVYEVIY"
misc_feature 1119..1490
/gene="TLE3"
/gene_synonym="ESG"
/gene_synonym="ESG3"
/gene_synonym="KIAA1547"
/note="TLE_N; Region: Groucho/TLE N-terminal Q-rich
domain. The N-terminal domain of the Grouch/TLE
co-repressor proteins are involved in oligomerisation"
/db_xref="CDD:pfam03920"
misc_feature 2535..3395
/gene="TLE3"
/gene_synonym="ESG"
/gene_synonym="ESG3"
/gene_synonym="KIAA1547"
/note="COG2319; Region: FOG: WD40 repeat [General function
prediction only]"
/db_xref="CDD:COG2319"
BASE COUNT 727 a 1259 c 1116 g 631 t
ORIGIN
1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcgtcc ccttcgcctg
61 tctgtgtgtg gtatccgtag gtccggggca cttttttttt ggtgtgtgtg tgtgtgcgtg
121 cgcgcgtgtg tgtgtgttgg gtgtgtgtgt tttgggggtt tgccggggcg cggagaggag
181 agccgggccg aggggaagga aggaagccgt agagctcccc ggtctcgggc tgcgtctccc
241 ctccagcgct ctcctgcctg tgcgctccga cgcggcagcg gcggtggcgc tgagcgctcc
301 tcggtgggga cgcggtgctc aagctgggag cagcgagaac cctttgcgga ggcttcccgt
361 gcccgctgga cttaggatgc cagggcgttt gatttgcacc tactgagccc ggagttcctc
421 cccggccctg ggaagggctt gcagcggcgg cggcggcggc ggcagcggta gtagcagacg
481 gaacagcagg ctctcctctc cgaggggggg cgtcgaagcg cccgcgccgg gctcccgccc
541 tcaccctccg gcgctcctgc ggccccaagc caccacctcg tagcccgcct ccttcctctt
601 ctcgccgcga gccccaggcc cggacgcctc taggatcgga cccgcgcgcc ccggatgctt
661 ggggctgccc cggcgcgccc ccctacaggc gcgacccgct gagtgacccg gagggggccc
721 gagctcgccc caggaggggc ccccggcctc gggaccccgc gccggacctg ctggggagcc
781 gacgatgtcc gcgcagtccc aggcattgac gcgctcgacg cagcccaggg aaggcggccg
841 gccgctgccc gccgagccct aggcgcacaa agcccgcgcc cgccgcccgg ccccggcgcc
901 cgccgacgac tttgccgcct gctccgcggc tctttgtctc cacttggggc gggcgcccga
961 ctctgggatt tcgctgcgag aacgagctgg gggggccggg ggcgagctct cggtttcccg
1021 gccgcccccc gctcgggctc ggctcccccc tcccccgcac ctccccggcc cgggctctcg
1081 gcgcttccac gctctcggaa tcacgacccc tccctgccat gtatccgcag ggcagacatc
1141 cggctcccca tcaacccggg cagccgggat ttaaattcac ggtggctgag tcttgtgaca
1201 ggatcaaaga cgaattccag ttcctgcaag ctcagtatca cagcctcaaa gtggagtacg
1261 acaagctggc aaacgagaag acggagatgc agcgccatta tgtgatgtac tatgagatgt
1321 cctatggctt gaacattgaa atgcacaagc agacagagat tgcgaagaga ctgaacacaa
1381 ttttagcaca gatcatgcct ttcctgtcac aagagcacca gcagcaggtg gcgcaggcag
1441 tggagcgcgc caagcaggtc accatgacgg agctgaacgc catcatcggg cagcagcagc
1501 tccaggcgca gcacctctcc catgccacac acggcccccc ggtccagttg ccaccccacc
1561 cgtcaggtct ccagcctcca ggaatccccc cagtgacagg gagcagctcc gggctgctgg
1621 cactgggcgc cctgggcagc caggcccatc tgacggtgaa ggatgagaag aaccaccatg
1681 aactcgatca cagagagaga gaatccagtg cgaataactc tgtgtcaccc tcggaaagcc
1741 tccgggccag tgagaagcac cggggctctg cggactacag catggaagcc aagaagcgga
1801 aggcggagga gaaggacagc ttgagccgat acgacagtga tggggacaag agtgatgatc
1861 tggtggtgga tgtttccaat gaggaccccg caacgccccg ggtcagcccg gcacactccc
1921 ctcctgaaaa tgggctggac aaggcccgta gcctgaaaaa agatgccccc accagccctg
1981 cctcggtggc ctcttccagt agcacacctt cctccaagac caaagacctt ggtcataacg
2041 acaaatcctc cacccctggg ctcaagtcca acacaccaac cccaaggaac gacgccccaa
2101 ctccaggcac cagcacgacc ccagggctca ggtcgatgcc gggtaaacct ccgggcatgg
2161 acccgatagg tataatggcc tcggctctgc gcacgcccat ctccatcacc agctcctatg
2221 cggcgccctt cgccatgatg agccaccatg agatgaacgg ctccctcacc agtcctggcg
2281 cctacgccgg cctccacaac atcccacccc agatgagcgc cgccgccgct gctgcagccg
2341 ctgcctatgg ccgatcgcca atggttggtt ttgaccctca ccccccgatg cgggccacag
2401 gcctcccctc aagcctggcc tccattcctg gaggaaaacc agcgtactca ttccatgtga
2461 gtgctgatgg gcagatgcag cccgtgccct tcccccacga cgccctggca ggccccggca
2521 tcccgaggca cgcccggcag atcaacacac tcagccacgg ggaggtggtg tgtgccgtga
2581 ccatcagcaa ccccacgagg cacgtctaca caggtggcaa gggctgcgtg aagatctggg
2641 acatcagcca gccaggcagc aagagcccca tctcccagct ggactgcctg aacagggaca
2701 attacatccg ctcctgcaag ctgctccctg atgggcgcac gctcatcgtg ggcggcgagg
2761 ccagcacgct caccatctgg gacctggcct cacccacgcc ccgcatcaag gccgagctga
2821 cgtcctcggc tcccgcctgt tatgccctgg ccattagccc tgacgccaaa gtctgcttct
2881 cctgctgcag cgatgggaac attgctgtct gggacctgca caaccagacc ctggtcaggc
2941 agttccaggg ccacacagat ggggccagct gcatagacat ctcccatgat ggcaccaaac
3001 tgtggacagg gggcctggac aacacagtgc gctcctggga cctgcgggag ggccgacagc
3061 tacagcagca tgacttcact tcccagatct tctcgctggg ctactgcccc actggggagt
3121 ggctggctgt gggcatggag agcagcaacg tggaggtgct gcaccacacc aagcctgaca
3181 agtaccagct gcacctgcac gagagctgcg tgctctccct caagttcgcc tactgcggca
3241 agtggttcgt gagcactggg aaagataacc ttctcaacgc ctggaggacg ccttatggag
3301 ccagcatatt ccagtctaaa gaatcctcgt ctgtcttgag ttgtgacatt tcagcggatg
3361 acaaatacat tgtaacaggc tctggtgaca agaaggccac agtttatgag gtcatctact
3421 aaacaagaac tccagcaggg ctgtcaaact ctgggagaaa ccgactcggc tctgacaggg
3481 agacccccag gcgaggggcc ccgaggatgg cggaggatgg gccgcaggca gccgagcgtt
3541 cagggctgcg ctccggccgg ctgagagggc acgtgccccg tcacagtctg gactcctggg
3601 cctggattga tgtgtctcac agactcggaa gggttctgct cctcctcctc cccctgaaca
3661 atgctggcag ttgctacaaa tagatttatt ggaggcttat ggctccggtt cccccacaaa
3721 aaaaaaaaaa aaa
//