LOCUS BC041560 2890 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member
4, mRNA (cDNA clone MGC:52221 IMAGE:5812052), complete cds.
ACCESSION BC041560
VERSION BC041560.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2890)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2890)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (20-DEC-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 44 Row: o Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 5031914.
FEATURES Location/Qualifiers
source 1..2890
/db_xref="H-InvDB:HIT000052561"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:52221 IMAGE:5812052"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_47"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2890
/gene="ABCC4"
/gene_synonym="EST170205"
/gene_synonym="MOAT-B"
/gene_synonym="MOATB"
/gene_synonym="MRP4"
/db_xref="GeneID:10257"
/db_xref="MIM:605250"
CDS 103..2682
/gene="ABCC4"
/gene_synonym="EST170205"
/gene_synonym="MOAT-B"
/gene_synonym="MOATB"
/gene_synonym="MRP4"
/codon_start=1
/product="ABCC4 protein"
/protein_id="AAH41560.1"
/db_xref="GeneID:10257"
/db_xref="MIM:605250"
/translation="MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDM
YSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIE
ESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ
CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG
PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM
NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFV
TFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLL
DEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVI
KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD
AEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSG
IDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENV
PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWAN
KQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLH
NKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLSWLV
SNS"
misc_feature 331..2001
/gene="ABCC4"
/gene_synonym="EST170205"
/gene_synonym="MOAT-B"
/gene_synonym="MOATB"
/gene_synonym="MRP4"
/note="MdlB; Region: ABC-type multidrug transport system,
ATPase and permease components [Defense mechanisms]"
/db_xref="CDD:COG1132"
misc_feature 2242..2589
/gene="ABCC4"
/gene_synonym="EST170205"
/gene_synonym="MOAT-B"
/gene_synonym="MOATB"
/gene_synonym="MRP4"
/note="MdlB; Region: ABC-type multidrug transport system,
ATPase and permease components [Defense mechanisms]"
/db_xref="CDD:COG1132"
BASE COUNT 772 a 610 c 694 g 814 t
ORIGIN
1 ggccggagcc ccagcatccc tgcttgaggt ccaggagcgg agcccgcggc caccgccgcc
61 tgatcagcgc gaccccggcc cgcgcccgcc ccgcccggca agatgctgcc cgtgtaccag
121 gaggtgaagc ccaacccgct gcaggacgcg aacctctgct cacgcgtgtt cttctggtgg
181 ctcaatccct tgtttaaaat tggccataaa cggagattag aggaagatga tatgtattca
241 gtgctgccag aagaccgctc acagcacctt ggagaggagt tgcaagggtt ctgggataaa
301 gaagttttaa gagctgagaa tgacgcacag aagccttctt taacaagagc aatcataaag
361 tgttactgga aatcttattt agttttggga atttttacgt taattgagga aagtgccaaa
421 gtaatccagc ccatattttt gggaaaaatt attaattatt ttgaaaatta tgatcccatg
481 gattctgtgg ctttgaacac agcgtacgcc tatgccacgg tgctgacttt ttgcacgctc
541 attttggcta tactgcatca cttatatttt tatcacgttc agtgtgctgg gatgaggtta
601 cgagtagcca tgtgccatat gatttatcgg aaggcacttc gtcttagtaa catggccatg
661 gggaagacaa ccacaggcca gatagtcaat ctgctgtcca atgatgtgaa caagtttgat
721 caggtgacag tgttcttaca cttcctgtgg gcaggaccac tgcaggcgat cgcagtgact
781 gccctactct ggatggagat aggaatatcg tgccttgctg ggatggcagt tctaatcatt
841 ctcctgccct tgcaaagctg ttttgggaag ttgttctcat cactgaggag taaaactgca
901 actttcacgg atgccaggat caggaccatg aatgaagtta taactggtat aaggataata
961 aaaatgtacg cctgggaaaa gtcattttca aatcttatta ccaatttgag aaagaaggag
1021 atttccaaga ttctgagaag ttcctgcctc agggggatga atttggcttc gtttttcagt
1081 gcaagcaaaa tcatcgtgtt tgtgaccttc accacctacg tgctcctcgg cagtgtgatc
1141 acagccagcc gcgtgttcgt ggcagtgacg ctgtatgggg ctgtgcggct gacggttacc
1201 ctcttcttcc cctcagccat tgagagggtg tcagaggcaa tcgtcagcat ccgaagaatc
1261 cagacctttt tgctacttga tgagatatca cagcgcaacc gtcagctgcc gtcagatggt
1321 aaaaagatgg tgcatgtgca ggattttact gctttttggg ataaggcatc agagacccca
1381 actctacaag gcctttcctt tactgtcaga cctggcgaat tgttagctgt ggtcggcccc
1441 gtgggagcag ggaagtcatc actgttaagt gccgtgctcg gggaattggc cccaagtcac
1501 gggctggtca gcgtgcatgg aagaattgcc tatgtgtctc agcagccctg ggtgttctcg
1561 ggaactctga ggagtaatat tttatttggg aagaaatacg aaaaggaacg atatgaaaaa
1621 gtcataaagg cttgtgctct gaaaaaggat ttacagctgt tggaggatgg tgatctgact
1681 gtgataggag atcggggaac cacgctgagt ggagggcaga aagcacgggt aaaccttgca
1741 agagcagtgt atcaagatgc tgacatctat ctcctggacg atcctctcag tgcagtagat
1801 gcggaagtta gcagacactt gttcgaactg tgtatttgtc aaattttgca tgagaagatc
1861 acaattttag tgactcatca gttgcagtac ctcaaagctg caagtcagat tctgatattg
1921 aaagatggta aaatggtgca gaaggggact tacactgagt tcctaaaatc tggtatagat
1981 tttggctccc ttttaaagaa ggataatgag gaaagtgaac aacctccagt tccaggaact
2041 cccacactaa ggaatcgtac cttctcagag tcttcggttt ggtctcaaca atcttctaga
2101 ccctccttga aagatggtgc tctggagagc caagatacag agaatgtccc agttacacta
2161 tcagaggaga accgttctga aggaaaagtt ggttttcagg cctataagaa ttacttcaga
2221 gctggtgctc actggattgt cttcattttc cttattctcc taaacactgc agctcaggtt
2281 gcctatgtgc ttcaagattg gtggctttca tactgggcaa acaaacaaag tatgctaaat
2341 gtcactgtaa atggaggagg aaatgtaacc gagaagctag atcttaactg gtacttagga
2401 atttattcag gtttaactgt agctaccgtt ctttttggca tagcaagatc tctattggta
2461 ttctacgtcc ttgttaactc ttcacaaact ttgcacaaca aaatgtttga gtcaattctg
2521 aaagctccgg tattattctt tgatagaaat ccaataggaa gaattttaaa tcgtttctcc
2581 aaagacattg gacacttgga tgatttgctg ccgctgacgt ttttagattt catccagaga
2641 tgggatctcg ctgtgttgtc ctggctggtc tcaaactcct aggctcaagc aatcctcctc
2701 cctcctcaag caaacctcag tgctgggatt ataggcatga gccactgtac ctggctaaat
2761 gttgtttttt tgatattcaa tttttgttta tagaattttc atttgttttg ctcttatact
2821 tttcatcttt ttatgtttat tgaccaatta aatatcattt gggtaagcac ctaaaaaaaa
2881 aaaaaaaaaa
//