LOCUS BC041158 1833 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens cytochrome P450, family 4, subfamily A, polypeptide
11, mRNA (cDNA clone MGC:48730 IMAGE:5183289), complete cds.
ACCESSION BC041158
VERSION BC041158.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1833)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1833)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (16-DEC-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 84 Row: d Column: 19
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 13435387.
FEATURES Location/Qualifiers
source 1..1833
/db_xref="H-InvDB:HIT000052527"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:48730 IMAGE:5183289"
/tissue_type="Colon, Kidney, Stomach, adult, whole pooled"
/clone_lib="NIH_MGC_116"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1833
/gene="CYP4A11"
/gene_synonym="CP4Y"
/gene_synonym="CYP4A2"
/gene_synonym="CYP4AII"
/db_xref="GeneID:1579"
/db_xref="MIM:601310"
CDS 32..1399
/gene="CYP4A11"
/gene_synonym="CP4Y"
/gene_synonym="CYP4A2"
/gene_synonym="CYP4AII"
/codon_start=1
/product="CYP4A11 protein"
/protein_id="AAH41158.1"
/db_xref="GeneID:1579"
/db_xref="MIM:601310"
/translation="MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWL
LKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDP
DYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVG
LMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYI
QAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQK
EGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL
YALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRE
LSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPF
SGGSR"
misc_feature 236..1396
/gene="CYP4A11"
/gene_synonym="CP4Y"
/gene_synonym="CYP4A2"
/gene_synonym="CYP4AII"
/note="p450; Region: Cytochrome P450. Cytochrome P450s are
involved in the oxidative degradation of various
compounds. Particularly well known for their role in the
degradation of environmental toxins and mutagens.
Structure is mostly alpha, and binds a heme cofactor"
/db_xref="CDD:pfam00067"
BASE COUNT 497 a 484 c 442 g 410 t
ORIGIN
1 gggcactcag agatccagca ggtgctgcac catgagtgtc tctgtgctga gccccagcag
61 actcctgggt gatgtctctg gaatcctcca agcggcctcc ctgctcattc tgcttctgct
121 gctgatcaag gcagttcagc tctacctgca caggcagtgg ctgctcaaag ccctccagca
181 gttcccgtgc cctccctccc actggctctt cgggcacatc caggagctcc aacaggacca
241 ggagctacaa cggattcaga aatgggtgga gacattccca agtgcctgtc ctcattggct
301 atggggaggc aaagttcgtg tccagctcta tgaccctgac tatatgaagg tgattctggg
361 gagatcagac ccgaaatccc atggttccta cagattcctg gctccatgga ttgggtacgg
421 cttgctcctg ttgaatgggc agacatggtt ccagcatcga cggatgctga ccccagcctt
481 ccactatgac atcctgaagc cctatgtggg gctcatggca gactctgtac gagtgatgct
541 ggacaaatgg gaagagctcc ttggccagga ttcccctctg gaggtctttc agcacgtctc
601 cttgatgacc ctggacacca tcatgaagtg tgccttcagc catcagggca gcatccaggt
661 ggacaggaat tctcagtcct acatacaggc cattagtgac ctgaacaacc tggttttttc
721 ccgtgtgagg aatgcctttc accagaatga caccatctac agcctgacct ctgctggccg
781 ctggacacac cgcgcctgcc agctggccca tcagcacaca gaccaagtga tccaactgag
841 gaaggctcaa ctacagaagg agggggagct ggagaagatc aagaggaaga ggcatttgga
901 ttttctggat atcctcctct tggccaaaat ggagaatggg agcatcttgt cagacaagga
961 cctccgtgct gaggtggaca cgttcatgtt tgagggccac gacaccacag ccagtgggat
1021 ctcctggatc ctctatgctc tggccacaca ccccaagcat caggagaggt gccgggagga
1081 gatccacagc ctcctgggtg atggagcctc catcacctgg aaccacctgg accagatgcc
1141 ctacaccacc atgtgcatta aggaggcact gaggctctac ccaccggtgc caggcattgg
1201 cagagagctc agcactcccg tcaccttccc tgatgggcgc tccttgccca aaggtatcat
1261 ggtcctcctc tccatttatg gccttcacca caacccaaaa gtgtggccca acccagaggt
1321 gtttgaccct ttccgttttg caccgggttc tgctcaacac agccacgctt tcctgccctt
1381 ctcaggagga tcaaggtgag acgtcctgtg tggtaattcg aatagaggaa tgagggaagt
1441 ctctggtcaa ccctctgatc tttgtgagcc tgatgttcat atgtggcatc ttcaggtgtg
1501 ctcttaaatg ttggtatttg tgggaaagtc aggcacctgg tgtgggcgtc tctgtgtaca
1561 aaaggaaggt ggcattcaga gcaccccatg gagactttgc tccctctgct tcttcaaatg
1621 ggcagcctga attcactgtc agtgcatgtt ccaaacttca gtatattcat gtattttcct
1681 cactttaagg atatgaattc tcaaaattag atattctcca gtaaaaaaaa aaaaaaaaaa
1741 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//