LOCUS BC039695 4216 bp mRNA linear HUM 09-MAR-2007
DEFINITION Homo sapiens Janus kinase 2 (a protein tyrosine kinase), mRNA (cDNA
clone MGC:46028 IMAGE:5556026), complete cds.
ACCESSION BC039695
VERSION BC039695.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4216)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4216)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (12-NOV-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 79 Row: b Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 13325062.
FEATURES Location/Qualifiers
source 1..4216
/db_xref="H-InvDB:HIT000052230"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:46028 IMAGE:5556026"
/tissue_type="Uterus, leiomyosarcoma"
/clone_lib="NIH_MGC_71"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..4216
/gene="JAK2"
/db_xref="GeneID:3717"
/db_xref="HGNC:HGNC:6192"
/db_xref="MIM:147796"
CDS 108..3497
/gene="JAK2"
/codon_start=1
/product="JAK2 protein"
/protein_id="AAH39695.1"
/db_xref="GeneID:3717"
/db_xref="HGNC:HGNC:6192"
/db_xref="MIM:147796"
/translation="MGMACLTMTEMEGTSTSSIYQNGDISGNANSIDPVLQVYLYHSL
GKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHID
ESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVH
GWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDY
HILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGP
SGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSN
ESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLEN
IQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCL
ITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLV
FRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGD
YGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQE
FVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREE
DRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTL
WEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAI
IRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGN
FGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHR
DLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSV
ASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRP
DGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG"
BASE COUNT 1422 a 728 c 852 g 1214 t
ORIGIN
1 ccacgcgtcc gggcaacagg aacaagatgt gaactgtttc tcttctgcag aaaaagaggc
61 tcttcctcct cctcccgcga cggcaaatgt tctgaaaaag actctgcatg ggaatggcct
121 gccttacgat gacagaaatg gagggaacat ccacctcttc tatatatcag aatggtgata
181 tttctggaaa tgccaattct atagatccag ttcttcaggt gtatctttac cattcccttg
241 ggaaatctga ggcagattat ctgacctttc catctgggga gtatgttgca gaagaaatct
301 gtattgctgc ttctaaagct tgtggtatca cacctgtgta tcataatatg tttgctttaa
361 tgagtgaaac agaaaggatc tggtatccac ccaaccatgt cttccatata gatgagtcaa
421 ccaggcataa tgtactctac agaataagat tttactttcc tcgttggtat tgcagtggca
481 gcaacagagc ctatcggcat ggaatatctc gaggtgctga agctcctctt cttgatgact
541 ttgtcatgtc ttacctcttt gctcagtggc ggcatgattt tgtgcacgga tggataaaag
601 tacctgtgac tcatgaaaca caggaagaat gtcttgggat ggcagtgtta gatatgatga
661 gaatagccaa agaaaacgat caaaccccac tggccatcta taactctatc agctacaaga
721 cattcttacc aaaatgtatt cgagcaaaga tccaagacta tcatattttg acaaggaagc
781 gaataaggta cagatttcgc agatttattc agcaattcag ccaatgcaaa gccactgcca
841 gaaacttgaa acttaagtat cttataaatc tggaaactct gcagtctgcc ttctacacag
901 agaaatttga agtaaaagaa cctggaagtg gtccttcagg tgaggagatt tttgcaacca
961 ttataataac tggaaacggt ggaattcagt ggtcaagagg gaaacataaa gaaagtgaga
1021 cactgacaga acaggattta cagttatatt gcgattttcc taatattatt gatgtcagta
1081 ttaagcaagc aaaccaagag ggttcaaatg aaagccgagt tgtaactatc cataagcaag
1141 atggtaaaaa tctggaaatt gaacttagct cattaaggga agctttgtct ttcgtgtcat
1201 taattgatgg atattataga ttaactgcag atgcacatca ttacctctgt aaagaagtag
1261 cacctccagc cgtgcttgaa aatatacaaa gcaactgtca tggcccaatt tcgatggatt
1321 ttgccattag taaactgaag aaagcaggta atcagactgg actgtatgta cttcgatgca
1381 gtcctaagga ctttaataaa tattttttga cttttgctgt cgagcgagaa aatgtcattg
1441 aatataaaca ctgtttgatt acaaaaaatg agaatgaaga gtacaacctc agtgggacaa
1501 agaagaactt cagcagtctt aaagatcttt tgaattgtta ccagatggaa actgttcgct
1561 cagacaatat aattttccag tttactaaat gctgtccccc aaagccaaaa gataaatcaa
1621 accttctagt cttcagaacg aatggtgttt ctgatgtacc aacctcacca acattacaga
1681 ggcctactca tatgaaccaa atggtgtttc acaaaatcag aaatgaagat ttgatattta
1741 atgaaagcct tggccaaggc acttttacaa agatttttaa aggcgtacga agagaagtag
1801 gagactacgg tcaactgcat gaaacagaag ttcttttaaa agttctggat aaagcacaca
1861 gaaactattc agagtctttc tttgaagcag caagtatgat gagcaagctt tctcacaagc
1921 atttggtttt aaattatgga gtatgtgtct gtggagacga gaatattctg gttcaggagt
1981 ttgtaaaatt tggatcacta gatacatatc tgaaaaagaa taaaaattgt ataaatatat
2041 tatggaaact tgaagttgct aaacagttgg catgggccat gcattttcta gaagaaaaca
2101 cccttattca tgggaatgta tgtgccaaaa atattctgct tatcagagaa gaagacagga
2161 agacaggaaa tcctcctttc atcaaactta gtgatcctgg cattagtatt acagttttgc
2221 caaaggacat tcttcaggag agaataccat gggtaccacc tgaatgcatt gaaaatccta
2281 aaaatttaaa tttggcaaca gacaaatgga gttttggtac cactttgtgg gaaatctgca
2341 gtggaggaga taaacctcta agtgctctgg attctcaaag aaagctacaa ttttatgaag
2401 ataggcatca gcttcctgca ccaaagtggg cagaattagc aaaccttata aataattgta
2461 tggattatga accagatttc aggccttctt tcagagccat catacgagat cttaacagtt
2521 tgtttactcc agattatgaa ctattaacag aaaatgacat gttaccaaat atgaggatag
2581 gtgccctagg gttttctggt gcctttgaag accgggatcc tacacagttt gaagagagac
2641 atttgaaatt tctacagcaa cttggcaagg gtaattttgg gagtgtggag atgtgccggt
2701 atgaccctct acaggacaac actggggagg tggtcgctgt aaaaaagctt cagcatagta
2761 ctgaagagca cctaagagac tttgaaaggg aaattgaaat cctgaaatcc ctacagcatg
2821 acaacattgt aaagtacaag ggagtgtgct acagtgctgg tcggcgtaat ctaaaattaa
2881 ttatggaata tttaccatat ggaagtttac gagactatct tcaaaaacat aaagaacgga
2941 tagatcacat aaaacttctg cagtacacat ctcagatatg caagggtatg gagtatcttg
3001 gtacaaaaag gtatatccac agggatctgg caacgagaaa tatattggtg gagaacgaga
3061 acagagttaa aattggagat tttgggttaa ccaaagtctt gccacaagac aaagaatact
3121 ataaagtaaa agaacctggt gaaagtccca tattctggta tgctccagaa tcactgacag
3181 agagcaagtt ttctgtggcc tcagatgttt ggagctttgg agtggttctg tatgaacttt
3241 tcacatacat tgagaagagt aaaagtccac cagcggaatt tatgcgtatg attggcaatg
3301 acaaacaagg acagatgatc gtgttccatt tgatagaact tttgaagaat aatggaagat
3361 taccaagacc agatggatgc ccagatgaga tctatatgat catgacagaa tgctggaaca
3421 ataatgtaaa tcaacgcccc tcctttaggg atctagctct tcgagtggat caaataaggg
3481 ataacatggc tggatgaaag aaatgacctt cattctgaga ccaaagtaga tttacagaac
3541 aaagttttat atttcacatt gctgtggact attattacat atatcattat tatataaatc
3601 atgatgctag ccagcaaaga tgtgaaaata tctgctcaaa actttcaaag tttagtaagt
3661 ttttcttcat gaggccacca gtaaaagaca ttaatgagaa ttccttagca aggattttgt
3721 aagaagtttc ttaaacattg tcagttaaca tcactcttgt ctggcaaaag aaaaaaaata
3781 gactttttca actcagcttt ttgagacctg aaaaaattat tatgtaaatt ttgcaatgtt
3841 aaagatgcac agaatatgta tgtatagttt ttaccacagt ggatgtataa taccttggca
3901 tcttgtgtga tgttttacac acatgagggc tggtgttcat taatactgtt ttctaatttt
3961 tccatagtta atctataatt aattacttca ctatacaaac aaattaagat gttcagataa
4021 ttgaataagt acctttgtgt ccttgttcat ttatatcgct ggccagcatt ataagcaggt
4081 gtatactttt agcttgtagt tccatgtact gtaaatattt ttcacataaa gggaacaaat
4141 gtctagtttt atttgtatag gaaatttccc tgaccctaaa taatacattt tgaaatgaaa
4201 caaaaaaaaa aaaaaa
//