LOCUS BC039591 1872 bp mRNA linear HUM 26-APR-2004 DEFINITION Homo sapiens Rho GTPase activating protein 25, mRNA (cDNA clone MGC:48798 IMAGE:5757311), complete cds. ACCESSION BC039591 VERSION BC039591.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1872) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1872) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (01-NOV-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: Life Technologies, Inc. cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Institute for Systems Biology http://www.systemsbiology.org contact: amadan@systemsbiology.org Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 84 Row: l Column: 2 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 7661881. FEATURES Location/Qualifiers source 1..1872 /db_xref="H-InvDB:HIT000052219" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:48798 IMAGE:5757311" /tissue_type="Blood, adult leukocytes" /clone_lib="NIH_MGC_118" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..1872 /gene="ARHGAP25" /gene_synonym="KIAA0053" /db_xref="GeneID:9938" CDS 242..1618 /gene="ARHGAP25" /gene_synonym="KIAA0053" /codon_start=1 /product="ARHGAP25 protein" /protein_id="AAH39591.1" /db_xref="GeneID:9938" /translation="MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMG WLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGK FVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLDETVA YEQKFGPHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDR DTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPR DNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQR VMTMMIRDHEVLFPKSKDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSS MVRCREPSCFHWVLPLVQAIPCKACSRVAIWGVLGDAVAVGAAATDSSEHTLKAWPLS KSSFYWHL" misc_feature 359..670 /gene="ARHGAP25" /gene_synonym="KIAA0053" /note="PH; Region: Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids" /db_xref="CDD:smart00233" misc_feature 692..1261 /gene="ARHGAP25" /gene_synonym="KIAA0053" /note="RhoGAP; Region: GTPase-activator protein for Rho-like GTPases" /db_xref="CDD:cd00159" BASE COUNT 447 a 495 c 507 g 423 t ORIGIN 1 gaatgacggg gcccgccgcg gtgccggact gcctgtgcac ggggccaccg actgcagcct 61 gggttttatt cttggcctgg ccctgaccgg gagctggccc ctcggctgct tctctggctc 121 gggggggact ttctctggct cagatccgga cccctgaact ggacctggtt gtcgtccccc 181 cgcttctcag ccccctctgg ggttcctctc tcctctccgc ccactctttg ctcactgccc 241 catgtccctc ggtcagtcgg cctgtctgtt cctctctata gctcggtcaa ggagtgtgat 301 gactggcgag cagatggctg ccttccatcc atcgtccacc cccaacccgc tggagaggcc 361 catcaagatg ggctggctga agaagcagag gtccatcgtg aagaactggc agcagaggta 421 ctttgtgctg agggcgcagc agctctacta ctacaaggat gaagaggaca cgaagcccca 481 gggctgcatg tatctaccag gatgtacaat caaggagatc gccacaaacc cagaagaagc 541 tgggaagttt gtctttgaaa tcattccagc ctcatgggac cagaatcgca tgggacagga 601 ctcctatgtc ctcatggcca gctctcaggc ggagatggag gagtgggtta aattcctcag 661 gagagttgct ggcacaccct gtggagcagt gtttggccag cgcttggatg agactgtggc 721 ctatgaacag aaattcggcc cccatctggt gcccatcctg gtggagaaat gtgcagagtt 781 catcctggag cacggccgga atgaagaggg catcttccgt ctgcctgggc aggacaacct 841 ggtgaagcag ctgagagacg cttttgatgc tggggagcgg ccctcctttg acagagacac 901 agatgtgcac actgtggctt ccctgttaaa gctctacctc cgagacctcc cagagcccgt 961 ggttccctgg agccagtacg aagggttcct gctctgtggg cagctcacga atgcggatga 1021 ggcaaaggct cagcaggagt tgatgaagca gctctccatc cttcctcgtg acaactatag 1081 tctcctgagc tacatctgca ggttcctaca tgaaatacag ctgaactgtg ctgttaacaa 1141 gatgagtgtg gacaacctgg ctactgtgat tggtgtgaat ctcatcaggt cgaaggtcga 1201 agaccctgcc gtgatcatga gagggactcc tcagatccaa agagtgatga ctatgatgat 1261 cagagaccat gaagtcctct tccccaagtc caaggatata cccctgtcac cccctgccca 1321 gaaaaatgac cccaagaaag ctccagtggc ccgaagctct gtaggctggg atgccactga 1381 agacctccga atttctagga cagacagctt cagtagcatg gtaaggtgca gagaaccttc 1441 ctgcttccat tgggttcttc ctttagtcca ggccatccca tgtaaggcct gctctcgggt 1501 ggcaatttgg ggagttttag gtgatgcagt ggcagtgggc gctgctgcta cagactcatc 1561 tgaacacacc ttgaaagcct ggcctctttc caaatctagt ttctattggc atctttgagg 1621 ggggtgagtg acaagtgtgc caatcaccca gtgactgagc aatgaggtcc tcactgaagc 1681 ccactctgaa agagagactc aaatacagtc cagagaagtt cagtgggaaa aatgtataca 1741 acattgtaaa tgttttggtc agaattgttg aaaattctgg gtgaacgtcc agagaaaact 1801 ggtttcctgc taacccatga aacgtgattc ctttctcaga gtaaaaaaaa aaaaaaaaaa 1861 aaaaaaaaaa aa //