LOCUS BC038510 4157 bp mRNA linear HUM 17-JUL-2006
DEFINITION Homo sapiens signal-regulatory protein alpha, mRNA (cDNA clone
MGC:43149 IMAGE:5261789), complete cds.
ACCESSION BC038510
VERSION BC038510.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4157)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4157)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (07-OCT-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 25, 2003 this sequence version replaced BC038510.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 73 Row: e Column: 17.
FEATURES Location/Qualifiers
source 1..4157
/db_xref="H-InvDB:HIT000052046"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:43149 IMAGE:5261789"
/tissue_type="Brain, hippocampus"
/clone_lib="NIH_MGC_95"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..4157
/gene="SIRPA"
/gene_synonym="BIT"
/gene_synonym="CD172A"
/gene_synonym="MFR"
/gene_synonym="MYD-1"
/gene_synonym="P84"
/gene_synonym="SHPS-1"
/gene_synonym="SHPS1"
/gene_synonym="SIRP"
/gene_synonym="SIRP-ALPHA-1"
/gene_synonym="SIRPalpha"
/gene_synonym="SIRPalpha2"
/db_xref="GeneID:140885"
/db_xref="HGNC:HGNC:9662"
/db_xref="MIM:602461"
CDS 269..1780
/gene="SIRPA"
/gene_synonym="BIT"
/gene_synonym="CD172A"
/gene_synonym="MFR"
/gene_synonym="MYD-1"
/gene_synonym="P84"
/gene_synonym="SHPS-1"
/gene_synonym="SHPS1"
/gene_synonym="SIRP"
/gene_synonym="SIRP-ALPHA-1"
/gene_synonym="SIRPalpha"
/gene_synonym="SIRPalpha2"
/codon_start=1
/product="signal-regulatory protein alpha"
/protein_id="AAH38510.1"
/db_xref="GeneID:140885"
/db_xref="HGNC:HGNC:9662"
/db_xref="MIM:602461"
/translation="MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVS
VAAGESAILHCTVTSLIPVGPIQWFRGAGPARELIYNQKEGHFPRVTTVSESTKRENM
DFSISISNITPADAGTYYCVKFRKGSPDTEFKSGAGTELSVRAKPSAPVVSGPAARAT
PQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTR
EDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRK
FYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEH
DGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALYL
VRIRQKKAQGSTSSTRLHEPEKNAREITQDTNDITYADLNLPKGKKPAPQAAEPNNHT
EYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK"
BASE COUNT 976 a 1227 c 1084 g 870 t
ORIGIN
1 ctctctggcc gcccctggct ttatttctcg cgcgcttggg gtctctccca gtctccgtct
61 ctccatttct cctggggggc ggggaggggg ggtctccaaa aaccgcggcg gcggcggcgg
121 ccgctccagg cgcccgttcc ggagtcgggg ggaggcccag ccgggagggg ggaagggggg
181 gagccttagt catttccccg ctccagcctg ctcccgcccg agcgcgcact cacggccgct
241 ctccctcctc gctccgcagc cgcggcccat ggagcccgcc ggcccggccc ccggccgcct
301 cgggccgctg ctctgcctgc tgctcgccgc gtcctgcgcc tggtcaggag tggcgggtga
361 ggaggagctg caggtgattc agcctgacaa gtccgtatca gttgcagctg gagagtcggc
421 cattctgcac tgcactgtga cctccctgat ccctgtgggg cccatccagt ggttcagagg
481 agctggacca gcccgggaat taatctacaa tcaaaaagaa ggccacttcc cccgggtaac
541 aactgtttca gagtccacaa agagagaaaa catggacttt tccatcagca tcagtaacat
601 caccccagca gatgccggca cctactactg tgtgaagttc cggaaaggga gccctgacac
661 ggagtttaag tctggagcag gcactgagct gtctgtgcgt gccaaaccct ctgcccccgt
721 ggtatcgggc cctgcggcga gggccacacc tcagcacaca gtgagcttca cctgcgagtc
781 ccacggcttc tcacccagag acatcaccct gaaatggttc aaaaatggga atgagctctc
841 agacttccag accaacgtgg accccgtagg agagagcgtg tcctacagca tccacagcac
901 agccaaggtg gtgctgaccc gcgaggacgt tcactctcaa gtcatctgcg aggtggccca
961 cgtcaccttg cagggggacc ctcttcgtgg gactgccaac ttgtctgaga ccatccgagt
1021 tccacccacc ttggaggtta ctcaacagcc cgtgagggca gagaaccagg tgaatgtcac
1081 ctgccaggtg aggaagttct acccccagag actacagctg acctggttgg agaatggaaa
1141 cgtgtcccgg acagaaacgg cctcaaccgt tacagagaac aaggatggta cctacaactg
1201 gatgagctgg ctcctggtga atgtatctgc ccacagggat gatgtgaagc tcacctgcca
1261 ggtggagcat gacgggcagc cagcggtcag caaaagccat gacctgaagg tctcagccca
1321 cccgaaggag cagggctcaa ataccgccgc tgagaacact ggatctaatg aacggaacat
1381 ctatattgtg gtgggtgtgg tgtgcacctt gctggtggcc ctactgatgg cggccctcta
1441 cctcgtccga atcagacaga agaaagccca gggctccact tcttctacaa ggttgcatga
1501 gcccgagaag aatgccagag aaataacaca ggacacaaat gatatcacat atgcagacct
1561 gaacctgccc aaggggaaga agcctgctcc ccaggctgcg gagcccaaca accacacgga
1621 gtatgccagc attcagacca gcccgcagcc cgcgtcggag gacaccctca cctatgctga
1681 cctggacatg gtccacctca accggacccc caagcagccg gcccccaagc ctgagccgtc
1741 cttctcagag tacgccagcg tccaggtccc gaggaagtga atgggaccgt ggtttgctct
1801 agcacccatc tctacgcgct ttcttgtccc acagggagcc gccgtgatga gcacagccaa
1861 cccagttccc agagggctgg ggcggtgcag gctctgggac ccagggccag ggtggctctt
1921 ctctccccac ccctccttgg ctctccagca cttcctgggc agccacggcc ccctcccccc
1981 acattgccac atacctggag gctgacgttg ccaaaccagc cagggaacca acctgggaag
2041 tggccagaac tgcctggggt ccaagaactg ttgtgcctcc gtccatcacc atgtgggttt
2101 tgaagaccct cgactgcctc cccgatgctc cgaagcctga tcttccaggg tggggaggag
2161 aaaatcccac ctcccctgac ctccaccacc tccaccacca ccaccaccac caccaccacc
2221 accaccacta ccaccaccac ccaactgggg ctagagtggg gaagatttcc cctttagatc
2281 aaactgcccc ttccatggaa aagctggaaa aaaactctgg aacccatatc caggcttggt
2341 gaggttgctg ccaacagtcc tggcctcccc catccctagg ctaaagagcc atgagtcctg
2401 gaggaggaga ggaccccttc caaaggactg gagacaaaac cctctgcttc cttgggtccc
2461 tccaagactc cctggggccc aactgtgttg ctccacccgg acccatctct cccttctaga
2521 cctgagcttg cccctccagc tagcactaag caacatctcg ctgtggacgc ctgtaaatta
2581 ctgagaaatg tgaaacgtgc aatcttgaaa ctgaggtgtt agaaaacttg atctgtggtg
2641 ttttgttttg ttttttttct taaaacaaca gcaacgtgat cttggctgtc tgtcatgtgt
2701 tgaagtccat ggttgggtct tgtgaagtct gaggtttaac agtttgttgt cctggaggga
2761 ttttcttaca gcgaagactt gagttcctcc aagtcccaga accccaagaa tgggcaagaa
2821 ggatcaggtc agccactccc tggagacaca gccttctggc tgggactgac ttggccatgt
2881 tctcagctga gccacgcggc tggtagtgca gccttctgtg accccgctgt ggtaagtcca
2941 gcctgcccag ggctgctgag ggctgcctct tgacagtgca gtcttatcga gacccaacgc
3001 ctcagtctgc tcatccgtaa agtggggata gtgaagatga cacccctccc caccacctct
3061 cataagcact ttaggaacac acagagggta gggatagtgg ccctggccgt ctatcctacc
3121 cctttagtga ccgcccccat cccggctttc tgagctgatc cttgaagaag aaatcttcca
3181 tttctgctct caaaccctac tgggatcaaa ctggaataaa ttgaagacag ccagggggat
3241 ggtgcagctg tgaagctcgg gctgattccc cctctgtccc agaaggttgg ccagagggtg
3301 tgacccagtt accctttaac ccccaccctt ccagtcgggt gtgagggcct gaccgggccc
3361 agggcaagca gatgtcgcaa gccctattta ttcagtcttc actataactc ttagagttga
3421 gacgctaatg ttcatgactc ctggccttgg gatgcccaag ggatttctgg ctcaggctgt
3481 aaaagtagct gagccatcct gcccattcct ggaggtccta caggtgaaac tgcaggagct
3541 cagcatagac ccagctctct gggggatggt cacctggtga tttcaatgat ggcatccagg
3601 aattagctga gccaacagac catgtggaca gctttggcca gagctcccgt gtggcatctg
3661 ggagccacag tgacccagcc acctggctca ggctagttcc aaattccaaa agattggctt
3721 gtaaaccttc gtctccctct cttttaccca gagacagcac atacgtgtgc acacgcatgc
3781 acacacacat tcagtatttt aaaagaatgt tttcttggtg ccattttcat tttattttat
3841 tttttaatta ttggaggggg aaataaggga ataaggccaa ggaagatgta tagctttagc
3901 tttagcctgg caacctggag aatccacata ccttgtgtat tgaaccccag gaaaaggaag
3961 aggtcgaacc aaccctgcgg aaggagcatg gtttcaggag tttattttaa gactgctggg
4021 aaggaaacag gccccatttt gtatatagtt gcaacttaaa ctttttggct tgcaaaatat
4081 ttttgtaata aagatttctg ggtaataatg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
4141 aaagaaaaaa aaaaaaa
//