LOCUS BC033925 2899 bp mRNA linear HUM 06-OCT-2003
DEFINITION Homo sapiens SHC (Src homology 2 domain containing) transforming
protein 1, mRNA (cDNA clone MGC:39145 IMAGE:4896385), complete cds.
ACCESSION BC033925
VERSION BC033925.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2899)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2899)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 42 Row: j Column: 8
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 10835030.
FEATURES Location/Qualifiers
source 1..2899
/db_xref="H-InvDB:HIT000042029"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:39145 IMAGE:4896385"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2899
/gene="SHC1"
/gene_synonym="SHC"
/gene_synonym="SHCA"
/db_xref="GeneID:6464"
/db_xref="MIM:600560"
CDS 266..1375
/gene="SHC1"
/gene_synonym="SHC"
/gene_synonym="SHCA"
/codon_start=1
/product="SHC1 protein"
/protein_id="AAH33925.1"
/db_xref="GeneID:6464"
/db_xref="MIM:600560"
/translation="MSLCHRWRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQ
SISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYL
RNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAP
GAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQN
LDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFH
GKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHR
FESVSHLISYHMDNHLPIISAGSELCLQQPVERKL"
misc_feature 278..574
/gene="SHC1"
/gene_synonym="SHC"
/gene_synonym="SHCA"
/note="PID; Region: Phosphotyrosine interaction domain
(PTB/PID)"
/db_xref="CDD:pfam00640"
misc_feature 1085..1300
/gene="SHC1"
/gene_synonym="SHC"
/gene_synonym="SHCA"
/note="SH2; Region: SH2 domain"
/db_xref="CDD:pfam00017"
BASE COUNT 640 a 839 c 738 g 682 t
ORIGIN
1 gagagaagag gctccacgtt gggcggggat ggggcctgaa actgtctggg tctgagctgg
61 ggagcggaag ccacttgtcc ctctccctcc ccaggacttc tgtgactcct gggccacaga
121 ggtccaacca ggctaagggc ctggggatac cccctgcctg gcccccttgc ccaaactggc
181 aggggggcca ggctgggcag cagcccctct ttcacctcaa ctatggatct cctgcccccc
241 aagcccaagt acaatccact ccggaatgag tctctgtcat cgctggagga gtaacctgaa
301 atttgctgga atgccaatca ctctcaccgt ctccaccagc agcctcaacc tcatggccgc
361 agactgcaaa cagatcatcg ccaaccacca catgcaatct atctcatttg catccggcgg
421 ggatccggac acagccgagt atgtcgccta tgttgccaaa gaccctgtga atcagagagc
481 ctgccacatt ctggagtgtc ccgaagggct tgcccaggat gtcatcagca ccattggcca
541 ggccttcgag ttgcgcttca aacaatacct caggaaccca cccaaactgg tcacccctca
601 tgacaggatg gctggctttg atggctcagc atgggatgag gaggaggaag agccacctga
661 ccatcagtac tataatgact tcccggggaa ggaacccccc ttgggggggg tggtagacat
721 gaggcttcgg gaaggagccg ctccaggggc tgctcgaccc actgcaccca atgcccagac
781 ccccagccac ttgggagcta cattgcctgt aggacagcct gttgggggag atccagaagt
841 ccgcaaacag atgccacctc caccaccctg tccaggcaga gagctttttg atgatccctc
901 ctatgtcaac gtccagaacc tagacaaggc ccggcaagca gtgggtggtg ctgggccccc
961 caatcctgct atcaatggca gtgcaccccg ggacctgttt gacatgaagc ccttcgaaga
1021 tgctcttcgc gtgcctccac ctccccagtc ggtgtccatg gctgagcagc tccgagggga
1081 gccctggttc catgggaagc tgagccggcg ggaggctgag gcactgctgc agctcaatgg
1141 ggacttcctg gtacgggaga gcacgaccac acctggccag tatgtgctca ctggcttgca
1201 gagtgggcag cctaagcatt tgctactggt ggaccctgag ggtgtggttc ggactaagga
1261 tcaccgcttt gaaagtgtca gtcaccttat cagctaccac atggacaatc acttgcccat
1321 catctctgcg ggcagcgaac tgtgtctaca gcaacctgtg gagcggaaac tgtgatctgc
1381 cctagcgctc tcttccagaa gatgccctcc aatcctttcc accctattcc ctaactctcg
1441 ggacctcgtt tgggagtgtt ctgtgggctt ggccttgtgt cagagctggg agtagcatgg
1501 actctgggtt tcatatccag ctgagtgaga gggtttgagt caaaagcctg ggtgagaatc
1561 ctgcctctcc ccaaacatta atcaccaaag tattaatgta cagagtggcc cctcacctgg
1621 gcctttcctg tgccaacctg atgccccttc cccaagaagg tgagtgcttg tcatggaaaa
1681 tgtcctgtgg tgacaggccc agtggaacag tcacccttct gggcaagggg gaacaaatca
1741 cacctctggg cttcagggta tcccagaccc ctctcaacac ccgccccccc catgtttaaa
1801 ctttgtgcct ttgaccatct cttaggtcta atgatatttt atgcaaacag ttcttggacc
1861 cctgaattca atgacaggga tgccaacacc ttcttggctt ctgggacctg tgttcttgct
1921 gagcaccctc tccggtttgg gttgggataa cagaggcagg agtggcagct gtcccctctc
1981 cctggggata tgcaaccctt agagattgcc ccagagcccc actcccggcc aggcgggaga
2041 tggacccctc ccttgctcag tgcctcctgg ccggggcccc tcaccccaag gggtctgtat
2101 atacatttca taaggcctgc cctcccatgt tgcatgccta tgtactctac gccaaagtgc
2161 agcccttcct cctgaagcct ctgccctgcc tccctttctg ggagggcggg gtgggggtga
2221 ctgaatttgg gcctcttgta cagttaactc tcccaggtgg attttgtgga ggtgagaaaa
2281 ggggcattga gactataaag cagtagacaa tccccacata ccatctgtag agttggaact
2341 gcattctttt aaagttttat atgcatatat tttagggctg tagacttact ttcctatttt
2401 cttttccatt gcttattctt gagcacaaaa tgataatcaa ttattacatt tatacatcac
2461 ctttttgact tttccaagcc cttttacagc tcttggcatt ttcctcgcct aggcctgtga
2521 ggtaactggg atcgcacctt ttataccaga gacctgaggc agatgaaatt tatttccatc
2581 taggactaga aaaacttggg tctcttaccg cgagactgag aggcagaagt cagcccgaat
2641 gcctgtcagt ttcatggagg ggaaacgcaa aacctgcagt tcctgagtac cttctacagg
2701 cccggcccag cctaggcccg gggtggccac accacagcaa gccggccccc cctcttttgg
2761 ccttgtggat aagggagagt tgaccgtttt catcctggcc tccttttgct gtttggatgt
2821 ttccacgggt ctcacttata ccaaagggaa aactcttcat taaagtccgt atttcttcta
2881 aaaaaaaaaa aaaaaaaaa
//