LOCUS BC033756 2756 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens toll-like receptor 2, mRNA (cDNA clone MGC:45301
IMAGE:5213439), complete cds.
ACCESSION BC033756
VERSION BC033756.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2756)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2756)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 68 Row: o Column: 16
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 19718733.
FEATURES Location/Qualifiers
source 1..2756
/db_xref="H-InvDB:HIT000041939"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:45301 IMAGE:5213439"
/tissue_type="Blood, adult leukocytes"
/clone_lib="NIH_MGC_118"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2756
/gene="TLR2"
/gene_synonym="TIL4"
/db_xref="GeneID:7097"
/db_xref="MIM:603028"
CDS 151..2505
/gene="TLR2"
/gene_synonym="TIL4"
/codon_start=1
/product="TLR2 protein"
/protein_id="AAH33756.1"
/db_xref="GeneID:7097"
/db_xref="MIM:603028"
/translation="MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLN
SIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL
EHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMD
TFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFV
DVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQI
SGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSL
TERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTL
ILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHS
VTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISR
NAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDS
PSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAW
LQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPG
KWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPI
EKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS"
misc_feature 1747..1908
/gene="TLR2"
/gene_synonym="TIL4"
/note="LRRCT; Region: Leucine rich repeat C-terminal
domain"
/db_xref="CDD:smart00082"
misc_feature 2077..2502
/gene="TLR2"
/gene_synonym="TIL4"
/note="TIR; Region: TIR domain. The TIR domain is an
intracellular signaling domain found in MyD88, interleukin
1 receptor and the Toll receptor. Called TIR (by SMART?)
for Toll - Interleukin - Resistance"
/db_xref="CDD:pfam01582"
BASE COUNT 833 a 558 c 567 g 798 t
ORIGIN
1 gagaaagcgc agccaggcgg ctgctcggcg ttctctcagg tgactgctcg gagttctccc
61 agtgtttggt gttgcaagca ggatccaaag gagacctata gtgactccca ggagctctta
121 gtgaccaagt gaaggttgaa gcactggaca atgccacata ctttgtggat ggtgtgggtc
181 ttgggggtca tcatcagcct ctccaaggaa gaatcctcca atcaggcttc tctgtcttgt
241 gaccgcaatg gtatctgcaa gggcagctca ggatctttaa actccattcc ctcagggctc
301 acagaagctg taaaaagcct tgacctgtcc aacaacagga tcacctacat tagcaacagt
361 gacctacaga ggtgtgtgaa cctccaggct ctggtgctga catccaatgg aattaacaca
421 atagaggaag attctttttc ttccctgggc agtcttgaac atttagactt atcctataat
481 tacttatcta atttatcgtc ttcctggttc aagccccttt cttctttaac attcttaaac
541 ttactgggaa atccttacaa aaccctaggg gaaacatctc ttttttctca tctcacaaaa
601 ttgcaaatcc tgagagtggg aaatatggac accttcacta agattcaaag aaaagatttt
661 gctggactta ccttccttga ggaacttgag attgatgctt cagatctaca gagctatgag
721 ccaaaaagtt tgaagtcaat tcagaacgta agtcatctga tccttcatat gaagcagcat
781 attttactgc tggagatttt tgtagatgtt acaagttccg tggaatgttt ggaactgcga
841 gatactgatt tggacacttt ccatttttca gaactatcca ctggtgaaac aaattcattg
901 attaaaaagt ttacatttag aaatgtgaaa atcaccgatg aaagtttgtt tcaggttatg
961 aaacttttga atcagatttc tggattgtta gaattagagt ttgatgactg tacccttaat
1021 ggagttggta attttagagc atctgataat gacagagtta tagatccagg taaagtggaa
1081 acgttaacaa tccggaggct gcatattcca aggttttact tattttatga tctgagcact
1141 ttatattcac ttacagaaag agttaaaaga atcacagtag aaaacagtaa agtttttctg
1201 gttccttgtt tactttcaca acatttaaaa tcattagaat acttggatct cagtgaaaat
1261 ttgatggttg aagaatactt gaaaaattca gcctgtgagg atgcctggcc ctctctacaa
1321 actttaattt taaggcaaaa tcatttggca tcattggaaa aaaccggaga gactttgctc
1381 actctgaaaa acttgactaa cattgatatc agtaagaata gttttcattc tatgcctgaa
1441 acttgtcagt ggccagaaaa gatgaaatat ttgaacttat ccagcacacg aatacacagt
1501 gtaacaggct gcattcccaa gacactggaa attttagatg ttagcaacaa caatctcaat
1561 ttattttctt tgaatttgcc gcaactcaaa gaactttata tttccagaaa taagttgatg
1621 actctaccag atgcctccct cttacccatg ttactagtat tgaaaatcag taggaatgca
1681 ataactacgt tttctaagga gcaacttgac tcatttcaca cactgaagac tttggaagct
1741 ggtggcaata acttcatttg ctcctgtgaa ttcctctcct tcactcagga gcagcaagca
1801 ctggccaaag tcttgattga ttggccagca aattacctgt gtgactctcc atcccatgtg
1861 cgtggccagc aggttcagga tgtccgcctc tcggtgtcgg aatgtcacag gacagcactg
1921 gtgtctggca tgtgctgtgc tctgttcctg ctgatcctgc tcacgggggt cctgtgccac
1981 cgtttccatg gcctgtggta tatgaaaatg atgtgggcct ggctccaggc caaaaggaag
2041 cccaggaaag ctcccagcag gaacatctgc tatgatgcat ttgtttctta cagtgagcgg
2101 gatgcctact gggtggagaa ccttatggtc caggagctgg agaacttcaa tccccccttc
2161 aagttgtgtc ttcataagcg ggacttcatt cctggcaagt ggatcattga caatatcatt
2221 gactccattg aaaagagcca caaaactgtc tttgtgcttt ctgaaaactt tgtgaagagt
2281 gagtggtgca agtatgaact ggacttctcc catttccgtc tttttgatga gaacaatgat
2341 gctgccattc tcattcttct ggagcccatt gagaaaaaag ccattcccca gcgcttctgc
2401 aagctgcgga agataatgaa caccaagacc tacctggagt ggcccatgga cgaggctcag
2461 cgggaaggat tttgggtaaa tctgagagct gcgataaagt cctaggttcc catatttaag
2521 accagtcttt gtctagttgg gatctttatg tcactagtta tagttaagtt cattcagaca
2581 taattatata aaaactacgt ggatgtaccg tcatttgagg acttgcttac taaaactaca
2641 aaacttcaaa ttttgtctgg ggtgctgttt tataaacata tgccagattt aaaaaaaaaa
2701 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//