LOCUS BC033731 3175 bp mRNA linear HUM 08-FEB-2007
DEFINITION Homo sapiens adaptor protein, phosphotyrosine interaction, PH
domain and leucine zipper containing 2, mRNA (cDNA clone MGC:45069
IMAGE:5168590), complete cds.
ACCESSION BC033731
VERSION BC033731.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3175)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3175)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 68 Row: i Column: 14
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 24586662.
FEATURES Location/Qualifiers
source 1..3175
/db_xref="H-InvDB:HIT000041924"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:45069 IMAGE:5168590"
/tissue_type="Brain, adult medulla"
/clone_lib="NIH_MGC_119"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3175
/gene="APPL2"
/gene_synonym="DIP13B"
/db_xref="GeneID:55198"
/db_xref="HGNC:HGNC:18242"
/db_xref="MIM:606231"
CDS 123..2117
/gene="APPL2"
/gene_synonym="DIP13B"
/codon_start=1
/product="adaptor protein, phosphotyrosine interaction, PH
domain and leucine zipper containing 2"
/protein_id="AAH33731.1"
/db_xref="GeneID:55198"
/db_xref="HGNC:HGNC:18242"
/db_xref="MIM:606231"
/translation="MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAM
QRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTE
LAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVK
TEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMF
SKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRN
LIQKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVD
CEDRRYCFQITTPNGKSGIILQAESRKENEEWICAINNISRQIYLTDNPEAVAIKLNQ
TALQAVTPITSFGKKQESSCPSQNLKNSEMENENDKIVPKVTASLPEAEELIAPGTPI
QFDIVLPATEFLDQNRGSRRTNPFGETEDESFPEAEDSLLQQMFIVRFLGSMAVKTDS
TTEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQSLRLIDPQTQVSRANFELTSVTQF
AAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEA
LAQLMLSIPLTNDGKYVLLNDQPDDDDGNPNEHRGAESEA"
BASE COUNT 964 a 708 c 703 g 800 t
ORIGIN
1 gccgccgcgg gcacggagtg gccgccgcgt cgcctgagcc cagagcccgg gagtgctctc
61 ggccgccgcg tctcctgccc tctgtccttc caacccagcc ctcggctgag ccgcgccgca
121 ccatgcccgc cgtggacaag ctcctgctag aggaggcgtt gcaggacagc ccccagactc
181 gctctttact gagcgtgttt gaagaagatg ctggcaccct cacagactat accaaccagc
241 tgctccaggc aatgcagcgc gtctatggag cccagaatga gatgtgcctg gccacacaac
301 agctttctaa gcaactgctg gcatatgaaa aacagaactt tgctcttggc aaaggtgatg
361 aagaagtaat ttcaacactc cactattttt ccaaagtggt ggatgagctt aatcttctcc
421 atacagagct ggctaaacag ttggcagaca caatggttct acctatcata caattccgag
481 aaaaggatct cacagaagta agcactttaa aggatctatt tggactcgct agcaatgagc
541 atgacctctc aatggcaaaa tacagcaggc tgcctaagaa aaaggagaat gagaaggtga
601 agaccgaagt cggaaaagag gtggccgcgg cccggcggaa gcagcatctc tcctcccttc
661 agtactactg tgccctcaac gcgctgcagt acagaaagca aatggccatg atggagccca
721 tgataggctt tgcccatgga cagattaact tttttaagaa gggagcagag atgttttcca
781 aacgtatgga cagcttttta tcctccgttg cagacatggt tcaaagcatt caggtagaac
841 tggaagccga ggcggaaaag atgcgggtgt cccagcaaga attactttct gttgatgaat
901 ctgtttacac tccagactct gatgtggccg caccacagat caacaggaac ctcatccaga
961 aggctggtta ccttaatctt agaaacaaaa cagggctggt caccaccacc tgggagaggc
1021 tttatttctt cacccaaggc gggaatctca tgtgtcagcc caggggagcc gtggctggag
1081 gtttgatcca ggacctggac aactgctcag tgatggccgt ggattgcgaa gaccggcgct
1141 actgcttcca gatcaccacg cccaatggaa aatcgggaat aatcctccag gctgagagca
1201 gaaaggaaaa tgaagagtgg atatgtgcaa taaacaacat ctccagacag atctacctga
1261 ccgacaaccc tgaggcagtc gcgatcaagt tgaatcagac cgctctgcaa gcagtgactc
1321 ccattacaag ttttggaaaa aaacaagaaa gctcatgccc cagccagaac ctgaaaaatt
1381 cagagatgga aaatgaaaat gacaagattg ttcccaaagt aacagccagt ctacctgaag
1441 cagaggagct gatcgcgcct ggaacgccga ttcaattcga tattgtgctt cctgctacag
1501 aattccttga tcagaacaga gggagcaggc gtaccaaccc ttttggtgaa actgaggatg
1561 aatcatttcc agaagcagaa gattctcttt tgcagcagat gtttatagtt cggtttttgg
1621 gatcaatggc agttaaaaca gacagcacta ctgaagtgat ttatgaagcg atgagacaag
1681 tattggctgc tcgggctatt cataacatct tccgcatgac agaatcccat ctgatggtca
1741 ccagtcaatc tttgaggttg atagatccac agactcaagt atcaagggcc aattttgaac
1801 ttaccagtgt cacacaattt gctgctcatc aagaaaacaa gagactggtt ggttttgtca
1861 tccgtgttcc tgaatccact ggagaagaat ctctgagtac atacattttt gaaagcaact
1921 cagaaggcga aaagatatgt tatgctatta atttgggaaa agaaattatt gaggttcaga
1981 aggatccaga agcactggct caattaatgc tgtccatacc actaaccaat gatggaaaat
2041 atgtactgtt aaacgatcaa ccagatgacg atgatggaaa tccaaatgaa catagaggcg
2101 cagaatccga agcataactc acttgcgcct gtgggggaag agcaaacagg aaggagagct
2161 acctcctaag ggttttaacg tctctgacat acaggcacac tgacctgatt tccgaaggct
2221 gacaatcgtt tgtggaatgt aatcttgatg ccttgatact gagacttggg agggaaacta
2281 agaaatggtt gacagcgttc ccacccatct acaatgttat tttaggtgct ttgtggtaag
2341 tcttttttct tagattgcgc taaaatttct tagattgttc agcactcaga acaaaagttt
2401 gaaaaatgca ttgttcatat gaatgtcatc tcttttcagt ttccagtatc ctttttaaaa
2461 aatggcaaaa gcctagattt acaatttgat gaacactaaa tatttcttat taatataatc
2521 tatttttgta ttttacttaa tgagctttaa gtgcctgtcg ttctgaaaat tgtgtattta
2581 taattcagct tatctcataa ttggacctaa tagcatttct ttgtgcagtt aggtgacgag
2641 cactgctttg aggcccaagc actagtagag atgcgcgata caggtctagt ttcggtaact
2701 gttccagaca tcaagcaata aaaaaatgaa taccacaaaa gatgtttgat tttacagtgg
2761 agccttactg aaccagcatt cagaagttta aggtcctcct aggtatgagt atttttagta
2821 gtggatcact gtggacaggg tgcagctcta ccagttcctg tttcttctga gccagaccct
2881 cttcagggaa gggaccaatt aattttaaaa ctcacttgaa gcacagctgg tcatggggct
2941 tggtataaag ttcctatttc caccctgata cttccaattc ctggaacccc agcccactcc
3001 cccatccctc ctccctatca aactagtata atgattttga atcggtacag tgtgtttaac
3061 tgtaactaag ttcaacaaac tattattatc tttgtaataa attaacctag caataaaaat
3121 tattctgttt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
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