LOCUS BC032762 2514 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens optineurin, mRNA (cDNA clone MGC:44991 IMAGE:3457195),
complete cds.
ACCESSION BC032762
VERSION BC032762.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2514)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2514)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (06-JUN-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 68 Row: a Column: 13
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 20149571.
FEATURES Location/Qualifiers
source 1..2514
/db_xref="H-InvDB:HIT000041711"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:44991 IMAGE:3457195"
/tissue_type="Cervix, carcinoma"
/clone_lib="NIH_MGC_12"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2514
/gene="OPTN"
/gene_synonym="FIP2"
/gene_synonym="GLC1E"
/gene_synonym="HIP7"
/gene_synonym="HYPL"
/gene_synonym="NRP"
/gene_synonym="TFIIIA-INTP"
/db_xref="GeneID:10133"
/db_xref="MIM:602432"
CDS 359..2074
/gene="OPTN"
/gene_synonym="FIP2"
/gene_synonym="GLC1E"
/gene_synonym="HIP7"
/gene_synonym="HYPL"
/gene_synonym="NRP"
/gene_synonym="TFIIIA-INTP"
/codon_start=1
/product="OPTN protein"
/protein_id="AAH32762.1"
/db_xref="GeneID:10133"
/db_xref="MIM:602432"
/translation="MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQM
KELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSH
ENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGI
VSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTSRSADGAKN
YFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGST
EKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERK
NSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQ
EHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEE
DLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSL
MEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHV
MDCII"
misc_feature 1055..1588
/gene="OPTN"
/gene_synonym="FIP2"
/gene_synonym="GLC1E"
/gene_synonym="HIP7"
/gene_synonym="HYPL"
/gene_synonym="NRP"
/gene_synonym="TFIIIA-INTP"
/note="Smc; Region: Chromosome segregation ATPases [Cell
division and chromosome partitioning]"
/db_xref="CDD:COG1196"
BASE COUNT 793 a 545 c 684 g 492 t
ORIGIN
1 ccacgcgtcc ggccccctcc gccaccgccg ccgcccgccg gcaggttccc tggtcagcgt
61 cccatcccgg tcgggagttc tctccaggcg gcacgatgcc gaggaaacag tgaccctgag
121 cgaagccaag ccgggcggca ggtgtggctt tgatagctgg tggtgccact tcctggcctt
181 ggatgagccg tacgcctctg taaacccaac ttcctcacct ttgaaacagc tgcctggttc
241 agcattaatg aagattagtc agtgacaggc ctggtgtgct gagtccgcac atagaagaat
301 caaaaatgtc caaaatgtaa ctggagagaa agtgggcaac ttttggagaa cttctgcaat
361 gtcccatcaa cctctcagct gcctcactga aaaggaggac agccccagtg aaagcacagg
421 aaatggaccc ccccacctgg cccacccaaa cctggacacg tttaccccgg aggagctgct
481 gcagcagatg aaagagctcc tgaccgagaa ccaccagctg aaagaagcca tgaagctaaa
541 taatcaagcc atgaaaggga gatttgagga gctttcggcc tggacagaga aacagaagga
601 agaacgccag ttttttgaga tacagagcaa agaagcaaaa gagcgtctaa tggccttgag
661 tcatgagaat gagaaattga aggaagagct tggaaaacta aaagggaaat cagaaaggtc
721 atctgaggac cccactgatg actccaggct tcccagggcc gaagcggagc aggaaaagga
781 ccagctcagg acccaggtgg tgaggctaca agcagagaag gcagacctgt tgggcatcgt
841 gtctgaactg cagctcaagc tgaactccag cggctcctca gaagattcct ttgttgaaat
901 taggatggct gaaggagaag cagaagggtc agtaaaagaa atcaagcata gtcctgggcc
961 cacgagaaca gtctccactg gcacgagcag atctgcagat ggggccaaga attacttcga
1021 acatgaggag ttaactgtga gccagctcct gctgtgccta agggaaggga atcagaaggt
1081 ggagagactt gaagttgcac tcaaggaggc caaagaaaga gtttcagatt ttgaaaagaa
1141 aacaagtaat cgttctgaga ttgaaaccca gacagagggg agcacagaga aagagaatga
1201 tgaagagaaa ggcccggaga ctgttggaag cgaagtggaa gcactgaacc tccaggtgac
1261 atctctgttt aaggagcttc aagaggctca tacaaaactc agcgaagctg agctaatgaa
1321 gaagagactt caagaaaagt gtcaggccct tgaaaggaaa aattctgcaa ttccatcaga
1381 gttgaatgaa aagcaagagc ttgtttatac taacaaaaag ttagagctac aagtggaaag
1441 catgctatca gaaatcaaaa tggaacaggc taaaacagag gatgaaaagt ccaaattaac
1501 tgtgctacag atgacacaca acaagcttct tcaagaacat aataatgcat tgaaaacaat
1561 tgaggaacta acaagaaaag agtcagaaaa agtggacagg gcagtgctga aggaactgag
1621 tgaaaaactg gaactggcag agaaggctct ggcttccaaa cagctgcaaa tggatgaaat
1681 gaagcaaacc attgccaagc aggaagagga cctggaaacc atgaccatcc tcagggctca
1741 gatggaagtt tactgttctg attttcatgc tgaaagagca gcgagagaga aaattcatga
1801 ggaaaaggag caactggcat tgcagctggc agttctgctg aaagagaatg atgctttcga
1861 agacggaggc aggcagtcct tgatggagat gcagagtcgt catggggcga gaacaagtga
1921 ctctgaccag caggcttacc ttgttcaaag aggagctgag gacagggact ggcggcaaca
1981 gcggaatatt ccgattcatt cctgccccaa gtgtggagag gttctgcctg acatagacac
2041 gttacagatt cacgtgatgg attgcatcat ttaagtgttg atgtatcacc tccccaaaac
2101 tgttggtaaa tgtcagattt tttcctccaa gagttgtgct tttgtgttat ttgttttcac
2161 tcaaatattt tgcctcatta ttcttgtttt aaaagaaaga aaacaggccg ggcacagtgg
2221 ctcatgcctg taatcccagc actttgggag gtcgaggtgg gtggatcact tggggtcagg
2281 gtttgagacc agcctggcca acatggcgga accctgtctc taccaaaatt acaaaaatta
2341 gccgagcatg gtggcgcatg cctgtagtcg cagctactcg cgaggttgag gcaggagaat
2401 tgcttgaacc caggaagtgg cagttgcagt gagccgagac gacaccactg cactccagcc
2461 tgggtgacag agggagactc tgtctcgaaa gaaagaaaga aaaaaaaaaa aaaa
//