LOCUS BC032224 5742 bp mRNA linear HUM 19-SEP-2016
DEFINITION Homo sapiens platelet-derived growth factor receptor, beta
polypeptide, mRNA (cDNA clone MGC:34052 IMAGE:5309813), complete
cds.
ACCESSION BC032224
VERSION BC032224.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5742)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 5742)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (06-JUN-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: David N. Louis, M.D.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 49 Row: p Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 68216043.
FEATURES Location/Qualifiers
source 1..5742
/db_xref="H-InvDB:HIT000041451"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:34052 IMAGE:5309813"
/tissue_type="Brain, anaplastic oligodendroglioma with
1p/19q loss"
/clone_lib="NCI_CGAP_Brn67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..5742
/gene="PDGFRB"
/gene_synonym="CD140B"
/gene_synonym="JTK12"
/gene_synonym="PDGF-R-beta"
/gene_synonym="PDGFR1"
/db_xref="GeneID:5159"
/db_xref="HGNC:HGNC:8804"
/db_xref="MIM:173410"
CDS 476..3796
/gene="PDGFRB"
/gene_synonym="CD140B"
/gene_synonym="JTK12"
/gene_synonym="PDGF-R-beta"
/gene_synonym="PDGFR1"
/codon_start=1
/product="platelet-derived growth factor receptor, beta
polypeptide"
/protein_id="AAH32224.1"
/db_xref="GeneID:5159"
/db_xref="HGNC:HGNC:8804"
/db_xref="MIM:173410"
/translation="MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVL
NVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTH
NDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTL
HEKKGDVALPVPYDHQRGFFGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSV
NAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSIL
HIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSR
TLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAG
HYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSA
CRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRC
TLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRW
KVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH
SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITE
YCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGY
MDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVL
SYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN
YISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFY
NAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQ
VDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP
EVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQ
LPDSGCPAPRAEAEDSFL"
BASE COUNT 1258 a 1715 c 1576 g 1193 t
ORIGIN
1 ccacgcgtcc ggaggctgcc agcagccagc agtgactgcc cgccctatct gggacccagg
61 atcgctctgt gagcaacttg gagccagaga ggagatcaac aaggaggagg agagagccgg
121 cccctcagcc ctgctgccca gcagcagcct gtgctcgccc tgcccaacgc agatagccag
181 acccagggcg gcccctctgg cggctctgct cctcccgaag gatgcttggg gagtgaggcg
241 aagctgggcc gctcctctcc cctacagcag cccccttcct ccatccctct gttctcctga
301 gccttcagga gcctgcacca gtcctgcctg tccttctact cagctgttac ccactctggg
361 accagcagtc tttctgataa ctgggagagg gcagtaagga ggacttcctg gagggggtga
421 ctgtccagag cctggaactg tgcccacacc agaagccatc agcagcaagg acaccatgcg
481 gcttccgggt gcgatgccag ctctggccct caaaggcgag ctgctgttgc tgtctctcct
541 gttacttctg gaaccacaga tctctcaggg cctggtcgtc acacccccgg ggccagagct
601 tgtcctcaat gtctccagca ccttcgttct gacctgctcg ggttcagctc cggtggtgtg
661 ggaacggatg tcccaggagc ccccacagga aatggccaag gcccaggatg gcaccttctc
721 cagcgtgctc acactgacca acctcactgg gctagacacg ggagaatact tttgcaccca
781 caatgactcc cgtggactgg agaccgatga gcggaaacgg ctctacatct ttgtgccaga
841 tcccaccgtg ggcttcctcc ctaatgatgc cgaggaacta ttcatctttc tcacggaaat
901 aactgagatc accattccat gccgagtaac agacccacag ctggtggtga cactgcacga
961 gaagaaaggg gacgttgcac tgcctgtccc ctatgatcac caacgtggct tttttggtat
1021 ctttgaggac agaagctaca tctgcaaaac caccattggg gacagggagg tggattctga
1081 tgcctactat gtctacagac tccaggtgtc atccatcaac gtctctgtga acgcagtgca
1141 gactgtggtc cgccagggtg agaacatcac cctcatgtgc attgtgatcg ggaatgaggt
1201 ggtcaacttc gagtggacat acccccgcaa agaaagtggg cggctggtgg agccggtgac
1261 tgacttcctc ttggatatgc cttaccacat ccgctccatc ctgcacatcc ccagtgccga
1321 gttagaagac tcggggacct acacctgcaa tgtgacggag agtgtgaatg accatcagga
1381 tgaaaaggcc atcaacatca ccgtggttga gagcggctac gtgcggctcc tgggagaggt
1441 gggcacacta caatttgctg agctgcatcg gagccggaca ctgcaggtag tgttcgaggc
1501 ctacccaccg cccactgtcc tgtggttcaa agacaaccgc accctgggcg actccagcgc
1561 tggcgaaatc gccctgtcca cgcgcaacgt gtcggagacc cggtatgtgt cagagctgac
1621 actggttcgc gtgaaggtgg cagaggctgg ccactacacc atgcgggcct tccatgagga
1681 tgctgaggtc cagctctcct tccagctaca gatcaatgtc cctgtccgag tgctggagct
1741 aagtgagagc caccctgaca gtggggaaca gacagtccgc tgtcgtggcc ggggcatgcc
1801 ccagccgaac atcatctggt ctgcctgcag agacctcaaa aggtgtccac gtgagctgcc
1861 gcccacgctg ctggggaaca gttccgaaga ggagagccag ctggagacta acgtgacgta
1921 ctgggaggag gagcaggagt ttgaggtggt gagcacactg cgtctgcagc acgtggatcg
1981 gccactgtcg gtgcgctgca cgctgcgcaa cgctgtgggc caggacacgc aggaggtcat
2041 cgtggtgcca cactccttgc cctttaaggt ggtggtgatc tcagccatcc tggccctggt
2101 ggtgctcacc atcatctccc ttatcatcct catcatgctt tggcagaaga agccacgtta
2161 cgagatccga tggaaggtga ttgagtctgt gagctctgac ggccatgagt acatctacgt
2221 ggaccccatg cagctgccct atgactccac gtgggagctg ccgcgggacc agcttgtgct
2281 gggacgcacc ctcggctctg gggcctttgg gcaggtggtg gaggccacgg ctcatggcct
2341 gagccattct caggccacga tgaaagtggc cgtcaagatg cttaaatcca cagcccgcag
2401 cagtgagaag caagccctta tgtcggagct gaagatcatg agtcaccttg ggccccacct
2461 gaacgtggtc aacctgttgg gggcctgcac caaaggagga cccatctata tcatcactga
2521 gtactgccgc tacggagacc tggtggacta cctgcaccgc aacaaacaca ccttcctgca
2581 gcaccactcc gacaagcgcc gcccgcccag cgcggagctc tacagcaatg ctctgcccgt
2641 tgggctcccc ctgcccagcc atgtgtcctt gaccggggag agcgacggtg gctacatgga
2701 catgagcaag gacgagtcgg tggactatgt gcccatgctg gacatgaaag gagacgtcaa
2761 atatgcagac atcgagtcct ccaactacat ggccccttac gataactacg ttccctctgc
2821 ccctgagagg acctgccgag caactttgat caacgagtct ccagtgctaa gctacatgga
2881 cctcgtgggc ttcagctacc aggtggccaa tggcatggag tttctggcct ccaagaactg
2941 cgtccacaga gacctggcgg ctaggaacgt gctcatctgt gaaggcaagc tggtcaagat
3001 ctgtgacttt ggcctggctc gagacatcat gcgggactcg aattacatct ccaaaggcag
3061 cacctttttg cctttaaagt ggatggctcc ggagagcatc ttcaacagcc tctacaccac
3121 cctgagcgac gtgtggtcct tcgggatcct gctctgggag atcttcacct tgggtggcac
3181 cccttaccca gagctgccca tgaacgagca gttctacaat gccatcaaac ggggttaccg
3241 catggcccag cctgcccatg cctccgacga gatctatgag atcatgcaga agtgctggga
3301 agagaagttt gagattcggc cccccttctc ccagctggtg ctgcttctcg agagactgtt
3361 gggcgaaggt tacaaaaaga agtaccagca ggtggatgag gagtttctga ggagtgacca
3421 cccagccatc cttcggtccc aggcccgctt gcctgggttc catggcctcc gatctcccct
3481 ggacaccagc tccgtcctct atactgccgt gcagcccaat gagggtgaca acgactatat
3541 catccccctg cctgacccca aacccgaggt tgctgacgag ggcccactgg agggttcccc
3601 cagcctagcc agctccaccc tgaatgaagt caacacctcc tcaaccatct cctgtgacag
3661 ccccctggag ccccaggacg aaccagagcc agagccccag cttgagctcc aggtggagcc
3721 ggagccagag ctggaacagt tgccggattc ggggtgccct gcgcctcggg cggaagcaga
3781 ggatagcttc ctgtaggggg ctggccccta ccctgccctg cctgaagctc cccccctgcc
3841 agcacccagc atctcctggc ctggcctgac cgggcttcct gtcagccagg ctgcccttat
3901 cagctgtccc cttctggaag ctttctgctc ctgacgtgtt gtgccccaaa ccctggggct
3961 ggcttaggag gcaagaaaac tgcaggggcc gtgaccagcc ctctgcctcc agggaggcca
4021 actgactctg agccagggtt cccccaggga actcagtttt cccatatgta agatgggaaa
4081 gttaggcttg atgacccaga atctaggatt ctctccctgg ctgacaggtg gggagaccga
4141 atccctccct gggaagattc ttggagttac tgaggtggta aattaacttt tttctgttca
4201 gccagctacc cctcaaggaa tcatagctct ctcctcgcac ttttatccac ccaggagcta
4261 gggaagagac cctagcctcc ctggctgctg gctgagctag ggcctagcct tgagcagtgt
4321 tgcctcatcc agaagaaagc cagtctcctc cctatgatgc cagtccctgc gttccctggc
4381 ccgagctggt ctggggccat taggcagcct aattaatgct ggaggctgag ccaagtacag
4441 gacaccccca gcctgcagcc cttgcccagg gcacttggag cacacgcagc catagcaagt
4501 gcctgtgtcc ctgtccttca ggcccatcag tcctggggct ttttctttat caccctcagt
4561 cttaatccat ccaccagagt ctagaaggcc agacgggccc cgcatctgtg atgagaatgt
4621 aaatgtgcca gtgtggagtg gccacgtgtg tgtgccagta tatggccctg gctctgcatt
4681 ggacctgcta tgaggctttg gaggaatccc tcaccctctc tgggcctcag tttccccttc
4741 aaaaaatgaa taagtcggac ttattaactc tgagtgcctt gccagcacta acattctaga
4801 gtattccagg tggttgcaca tttgtccaga tgaagcaagg ccatataccc taaacttcca
4861 tcctgggggt cagctgggct cctgggagat tccagatcac acatcacact ctggggactc
4921 aggaaccatg ccccttcccc aggcccccag caagtctcaa gaacacagct gcacaggcct
4981 tgacttagag tgacagccgg tgtcctggaa agcccccagc agctgcccca gggacatggg
5041 aagaccacgg gacctctttc actacccacg atgacctccg ggggtatcct gggcaaaagg
5101 gacaaagagg gcaaatgaga tcacctcctg cagcccacca ctccagcacc tgtgccgagg
5161 tctgcgtcga agacagaatg gacagtgagg acagttatgt cttgtaaaag acaagaagct
5221 tcagatgggt accccaagaa ggatgtgaga ggtgggcgct ttggaggttt gcccctcacc
5281 caccagctgc cccatccctg aggcagcgct ccatgggggt atggttttgt cactgcccag
5341 acctagcagt gacatctcat tgtccccagc ccagtgggca ttggaggtgc caggggagtc
5401 agggttgtag ccaagacgcc cccgcacggg gagggttggg aagggggtgc aggaagctca
5461 acccctctgg gcaccaaccc tgcattgcag gttggcacct tacttccctg ggatccccag
5521 agttggtcca aggagggaga gtgggttctc aatacggtac caaagatata atcacctagg
5581 tttacaaata tttttaggac tcacgttaac tcacatttat acagcagaaa tgctattttg
5641 tatgctgtta agtttttcta tctgtgtact tttttttaag ggaaagattt taatattaaa
5701 cctggtgctt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//