LOCUS BC030154 1653 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens ribonucleotide reductase M2 polypeptide, mRNA (cDNA
clone MGC:29692 IMAGE:4858919), complete cds.
ACCESSION BC030154
VERSION BC030154.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1653)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1653)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (07-MAY-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 39 Row: g Column: 24.
FEATURES Location/Qualifiers
source 1..1653
/db_xref="H-InvDB:HIT000040966"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:29692 IMAGE:4858919"
/tissue_type="Skin, melanotic melanoma, high MDR."
/clone_lib="NIH_MGC_49"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1653
/gene="RRM2"
/gene_synonym="R2"
/gene_synonym="RR2M"
/db_xref="GeneID:6241"
/db_xref="HGNC:HGNC:10452"
/db_xref="MIM:180390"
CDS 50..1219
/gene="RRM2"
/gene_synonym="R2"
/gene_synonym="RR2M"
/codon_start=1
/product="ribonucleotide reductase M2 polypeptide"
/protein_id="AAH30154.1"
/db_xref="GeneID:6241"
/db_xref="HGNC:HGNC:10452"
/db_xref="MIM:180390"
/translation="MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLA
SKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFW
TAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARC
FYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKE
ATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLM
FKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLE
LGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF"
BASE COUNT 453 a 379 c 394 g 427 t
ORIGIN
1 cccagccgtc ctgtcctggc tgctcgctct gcttcgctgc gccgccacta tgctctccct
61 ccgtgtcccg ctcgcgccca tcacggaccc gcagcagctg cagctctcgc cgctgaaggg
121 gctcagcttg gtcgacaagg agaacacgcc gccggccctg agcgggaccc gcgtcctggc
181 cagcaagacc gcgaggagga tcttccagga gcccacggag ccgaaaacta aagcagctgc
241 ccccggcgtg gaggatgagc cgctgctgag agaaaacccc cgccgctttg tcatcttccc
301 catcgagtac catgatatct ggcagatgta taagaaggca gaggcttcct tttggaccgc
361 cgaggaggtg gacctctcca aggacattca gcactgggaa tccctgaaac ccgaggagag
421 atattttata tcccatgttc tggctttctt tgcagcaagc gatggcatag taaatgaaaa
481 cttggtggag cgatttagcc aagaagttca gattacagaa gcccgctgtt tctatggctt
541 ccaaattgcc atggaaaaca tacattctga aatgtatagt cttcttattg acacttacat
601 aaaagatccc aaagaaaggg aatttctctt caatgccatt gaaacgatgc cttgtgtcaa
661 gaagaaggca gactgggcct tgcgctggat tggggacaaa gaggctacct atggtgaacg
721 tgttgtagcc tttgctgcag tggaaggcat tttcttttcc ggttcttttg cgtcgatatt
781 ctggctcaag aaacgaggac tgatgcctgg cctcacattt tctaatgaac ttattagcag
841 agatgagggt ttacactgtg attttgcttg cctgatgttc aaacacctgg tacacaaacc
901 atcggaggag agagtaagag aaataattat caatgctgtt cggatagaac aggagttcct
961 cactgaggcc ttgcctgtga agctcattgg gatgaattgc actctaatga agcaatacat
1021 tgagtttgtg gcagacagac ttatgctgga actgggtttt agcaaggttt tcagagtaga
1081 gaacccattt gactttatgg agaatatttc actggaagga aagactaact tctttgagaa
1141 gagagtaggc gagtatcaga ggatgggagt gatgtcaagt ccaacagaga attcttttac
1201 cttggatgct gacttctaaa tgaactgaag atgtgccctt acttggctga tttttttttt
1261 ccatctcata agaaaaatca gctgaagtgt taccaactag ccacaccatg aattgtccgt
1321 aatgttcatt aacagcatct ttaaaactgt gtagctacct cacaaccagt cctgtctgtt
1381 tatagtgctg gtagtatcac cttttgccag aaggcctggc tggctgtgac ttaccatagc
1441 agtgacaatg gcagtcttgg ctttaaagtg aggggtgacc ctttagtgag cttagcacag
1501 cgggattaaa cagtccttta accagcacag ccagttaaaa gatgcagcct cactgcttca
1561 acgcagattt taatgtttac ttaaatataa acctggcact ttacaaacaa ataaacattg
1621 tttgtactca caaaaaaaaa aaaaaaaaaa aaa
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