LOCUS BC029840 2646 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin
G/H synthase and cyclooxygenase), mRNA (cDNA clone MGC:34214
IMAGE:5174923), complete cds.
ACCESSION BC029840
VERSION BC029840.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2646)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2646)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (06-MAY-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 51 Row: k Column: 17
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 18104966.
FEATURES Location/Qualifiers
source 1..2646
/db_xref="H-InvDB:HIT000040896"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:34214 IMAGE:5174923"
/tissue_type="Brain, Lung, Testis, adult, pooled whole"
/clone_lib="NIH_MGC_115"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2646
/gene="PTGS1"
/gene_synonym="COX1"
/gene_synonym="COX3"
/gene_synonym="PCOX1"
/gene_synonym="PGG/HS"
/gene_synonym="PGHS-1"
/gene_synonym="PGHS1"
/gene_synonym="PHS1"
/gene_synonym="PTGHS"
/db_xref="GeneID:5742"
/db_xref="HGNC:HGNC:9604"
/db_xref="MIM:176805"
CDS 53..1852
/gene="PTGS1"
/gene_synonym="COX1"
/gene_synonym="COX3"
/gene_synonym="PCOX1"
/gene_synonym="PGG/HS"
/gene_synonym="PGHS-1"
/gene_synonym="PGHS1"
/gene_synonym="PHS1"
/gene_synonym="PTGHS"
/codon_start=1
/product="prostaglandin-endoperoxide synthase 1
(prostaglandin G/H synthase and cyclooxygenase)"
/protein_id="AAH29840.1"
/db_xref="GeneID:5742"
/db_xref="HGNC:HGNC:9604"
/db_xref="MIM:176805"
/translation="MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQG
ICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFV
NATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPT
PMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPG
FTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPR
GIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLI
LIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPD
SFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDV
IRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLL
EKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKL
VCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL"
BASE COUNT 582 a 717 c 688 g 659 t
ORIGIN
1 ggcgcacgca caggagcctg cactctgcgt cccgcacccc agcagccgcg ccatgagccg
61 gagtctcttg ctccggttct tgctgttcct gctcctgctc ccgccgctcc ccgtcctgct
121 cgcggaccca ggggcgccca cgccagtgaa tccctgttgt tactatccat gccagcacca
181 gggcatctgt gtccgcttcg gccttgaccg ctaccagtgt gactgcaccc gcacgggcta
241 ttccggcccc aactgcacca tccctggcct gtggacctgg ctccggaatt cactgcggcc
301 cagcccctct ttcacccact tcctgctcac tcacgggcgc tggttctggg agtttgtcaa
361 tgccaccttc atccgagaga tgctcatgcg cctggtactc acagtgcgct ccaaccttat
421 ccccagtccc cccacctaca actcagcaca tgactacatc agctgggagt ctttctccaa
481 cgtgagctat tacactcgta ttctgccctc tgtgcctaaa gattgcccca cacccatggg
541 aaccaaaggg aagaagcagt tgccagatgc ccagctcctg gcccgccgct tcctgctcag
601 gaggaagttc atacctgacc cccaaggcac caacctcatg tttgccttct ttgcacaaca
661 cttcacccac cagttcttca aaacttctgg caagatgggt cctggcttca ccaaggcctt
721 gggccatggg gtagacctcg gccacattta tggagacaat ctggagcgtc agtatcaact
781 gcggctcttt aaggatggga aactcaagta ccaggtgctg gatggagaaa tgtacccgcc
841 ctcggtagaa gaggcgcctg tgttgatgca ctacccccga ggcatcccgc cccagagcca
901 gatggctgtg ggccaggagg tgtttgggct gcttcctggg ctcatgctgt atgccacgct
961 ctggctacgt gagcacaacc gtgtgtgtga cctgctgaag gctgagcacc ccacctgggg
1021 cgatgagcag cttttccaga cgacccgcct catcctcata ggggagacca tcaagattgt
1081 catcgaggag tacgtgcagc agctgagtgg ctatttcctg cagctgaaat ttgacccaga
1141 gctgctgttc ggtgtccagt tccaataccg caaccgcatt gccatggagt tcaaccatct
1201 ctaccactgg caccccctca tgcctgactc cttcaaggtg ggctcccagg agtacagcta
1261 cgagcagttc ttgttcaaca cctccatgtt ggtggactat ggggttgagg ccctggtgga
1321 tgccttctct cgccagattg ctggccggat cggtgggggc aggaacatgg accaccacat
1381 cctgcatgtg gctgtggatg tcatcaggga gtctcgggag atgcggctgc agcccttcaa
1441 tgagtaccgc aagaggtttg gcatgaaacc ctacacctcc ttccaggagc tcgtaggaga
1501 gaaggagatg gcagcagagt tggaggaatt gtatggagac attgatgcgt tggagttcta
1561 ccctggactg cttcttgaaa agtgccatcc aaactctatc tttggggaga gtatgataga
1621 gattggggct cccttttccc tcaagggtct cctagggaat cccatctgtt ctccggagta
1681 ctggaagccg agcacatttg gcggcgaggt gggctttaac attgtcaaga cggccacact
1741 gaagaagctg gtctgcctca acaccaagac ctgtccctac gtttccttcc gtgtgccgga
1801 tgccagtcag gatgatgggc ctgctgtgga gcgaccatcc acagagctct gaggggcagg
1861 aaagcagcat tctggagggg agagctttgt gcttgtcatt ccagagtgct gaggccaggg
1921 ctgatggtct taaatgctca ttttctggtt tggcatggtg agtgttgggg ttgacattta
1981 gaactttaag tctcacccat tatctggaat attgtgattc tgtttattct tccagaatgc
2041 tgaactcctt gttagccctt cagattgtta ggagtggttc tcatttggtc tgccagaata
2101 ctgggttctt agttgacaac ctagaatgtc agatttctgg ttgatttgta acacagtcat
2161 tctaggatgt ggagctactg atgaaatctc tagaaagtta gggggttctt attttgcatt
2221 ccagaatctt gactttctga ttggtgattc aaagtgttgt gttcctggct gatgatccag
2281 aacagtggct cgtatcccaa atctgtcagc atctggctgt ctagaatgtg gatttgattc
2341 attttcctgt tcagtgagat atcatagaga cggagatcct aaggtccaac aagaatgcat
2401 tccctgaatc tgtgcctgca ctgagagggc aaggaagtgg ggtgttcttc ttgggacccc
2461 cactaagacc ctggtctgag gatgtagaga gaacaggtgg gctgtattca cgccattggt
2521 tggaagctac cagagctcta tccccatcca ggtcttgact catggcagct gtttctcatg
2581 aagctaataa aattcgcttt ctaaagttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
2641 aaaaaa
//